---
title: 'Senior Research Associate / Scientist, Proteomics Sample Prep at Glyphic Biotechnologies'
canonical: 'https://feeny.ai/job/senior-research-associate-scientist-proteomics-sample-prep-glyphic-qrqwbvv4kxpn'
type: 'job'
last_seen: '2026-09-05'
---

# Senior Research Associate / Scientist, Proteomics Sample Prep at Glyphic Biotechnologies

- **Company:** Glyphic Biotechnologies
- **Location:** Berkeley, CA
- **Posted:** 2026-08-20
- **Last confirmed live:** 2026-09-05
- **Apply:** https://job-boards.greenhouse.io/glyphicbiotechnologies/jobs/4376709009

## Job description

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

## What we are looking for in you

We're seeking a hands-on, detail-oriented Senior Research Associate / Scientist I to join our proteomics team and help scale our sample processing capacity. Sample volume is growing quickly, and we need someone who can take on the day-to-day execution of tissue and cell sample preparation and mass spec operation.

Reporting to our principal proteomics scientist, you'll spend most of your time at the bench. You'll follow established SOPs closely, prepare and run high volumes of samples, and help keep our Astral mass spec calibrated, well-maintained, and running smoothly. This is a wonderful opportunity to gain hands-on training on the Orbitrap Astral Zoom + Vanquish Neo platform from an experienced mass spec scientist, and growing ownership of the workflow as our automated systems come fully online.

This is an in-person position based at our Berkeley, CA location. Depending on where a candidate falls within our requirements, this position will be filled either as a full-time, exempt position with Glyphic or as a full-time contract position

## What you’ll do

Sample Preparation & Protein Enrichment

- Prepare tissue and cell samples for mass spectrometry–based proteomics, including precise tissue dissection and cell pellet processing
- Execute established protein and peptide enrichment strategies, including cell-surface labeling and immunopeptidomics workflows
- Follow validated protocols for protein extraction and purification across a range of sample types
- Utilize automation to achieve a sample throughput at 96x plate format scale.

Mass Spectrometry & Analytical Platforms

- Learn Orbitrap Astral Zoom operation and troubleshooting
- Operate and maintain the Orbitrap Astral Zoom, including routine instrument calibration
- Follow established SOPs closely to ensure consistent, reliable instrument performance

Collaboration & Communication

- Work closely with the proteomics and cross-functional teams to keep sample processing on schedule
- Document methods and maintain SOPs to support consistent, reproducible results
- Communicate proactively, surfacing issues early rather than letting them surface downstream

## What you need

Required:

- Industry or Academic experience relevant to the role and a degree in Proteomics, Chemical Biology, Biochemistry, Analytical Chemistry, or a related field including:
- BS/MS with 2+/0+ years (Senior Research Associate)
- BS/MS with 4+/2+ years (Scientist I)
- Hands-on experience with LC–MS/MS–based proteomics
- Experience processing precious, complex clinical samples to include tissue dissection and cell pellet handling
- Demonstrated experience in sample preparation, protein extraction, and enrichment strategies (chemical biology/enrichment strategies preferred)
- Familiarity with data independent acquisition (DIA)
- Excellent problem-solving skills and attention to detail
- Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds
- Ability to thrive in a fast-paced environment with evolving priorities
- Occasional weekend availability required (~1-2 hours)

Nice to have:

- Experience with Thermo Orbitrap mass specs and Vanquish Neo LCs
- Experience with cell surface proteomics or chemical labeling approaches
- Familiarity with immunopeptidomics workflows (MHC-I/MHC-II)
- Experience with performing LC-MS/MS on low-input samples (single-cell, spatial proteomics, immunopeptidomics)
- Familiarity with high-throughput proteomics workflows,  automation and sample multiplexing
- Understanding of protein chemistry, post-translational modifications, and quantitative proteomics
- Basic knowledge of bioinformatics tools or scripting (e.g., R, Python)

We’re looking for a teammate that:

- Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
- Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
- Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.
- Treats obstacles as problems to be creatively solved, not reasons something can’t be done.
- Applies sound judgment to the best available information, testing, learning, and iterating.
- Shares early and directly when assumptions change, results are unclear, or timelines are at risk.

## What you can expect from this role

Work environment:

- Collaborative culture where your ideas and expertise are valued

Professional growth:

- Learn from a diverse team of world-class scientists and engineers
- Opportunity to learn and operate state-of-the-art proteomics instruments

## Compensation

Estimated Base Salary $82,000-$129,150

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks:

- Employee Stock Option Plan
- 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
- Employer Retirement Contributions to 401(k)
- Generous Paid Time Off
- Paid Maternity and Paternity Leave
- Health & Wellbeing Program
- Office Snacks and Beverages
- Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

## About Glyphic Biotechnologies

## Company Overview
- **One-liner**: Glyphic Biotechnologies is developing a next-generation, single-molecule protein sequencing platform to unlock deep proteome insights for drug discovery and life science research.
- **Entity Type**: Private (Series A)
- **Headquarters**: Berkeley, CA, United States
- **Founded**: 2021
- **Founders**: Josh Yang (Founder, CEO & Board Member)

## Core Business
- **Primary Industry**: Biotechnology / Proteomics
- **Target Customers**: B2B – academic research institutions, biopharmaceutical companies, and diagnostics developers.
- **Mission/Purpose**: “To fundamentally rewrite the rules of proteomics” by delivering a scalable, high-throughput protein sequencing technology that enables first-in-class therapies and deeper biological understanding.

## Products & Services
- **ProSE™ (Protein Sequencing by Expansion)**: A proprietary platform that uses spatial expansion of amino acids to achieve single-molecule, de novo sequencing of proteins. The method discriminates all 20 standard amino acids plus post-translational modifications (PTMs) with unbiased accuracy. Samples are prepared via an initiating linker, expanded into a linear “ProSE molecule”, and read by a nanopore to generate distinct electrical signatures for each amino acid.

## Market Standing
- **Valuation / Market Cap**: Not disclosed
- **Key Metric**: Total Funding – **$42.7M** (as of latest funding round, including ~$38M Series A led by FoundersX Ventures in October 2025)
- **Notable Investors/Partners**: FoundersX Ventures (lead, Series A), National Institutes of Health (grant), Johnson & Johnson Robotics and Digital Solutions (grant), BioTools Innovator (non-equity assistance)
- **Growth Signals**: Headcount of 33 employees (+12.9% YoY); active job postings increased 166.7% month-over-month and 33.3% year-over-year; holds 10+ patents covering core IP.

## Competitive Advantages
- **Unbiased single-molecule sensitivity**: ProSE™ can distinguish all 20 amino acids and PTMs in a single read, a capability current mass-spectrometry-based methods struggle to achieve at scale.
- **Scalable de novo sequencing**: The expansion-based technology bypasses the need for reference databases, enabling truly novel protein identification.
- **Strong IP moat**: “Seminal IP” in protein sequencing methods with 10+ patents filed.
- **Team experience**: Leadership with backgrounds from Illumina, Exact Sciences, and Twist Bioscience, combining sequencing and biotech commercialization expertise.

## Strategic Focus
- Scaling the ProSE™ platform from prototype to a commercially viable high-throughput system.
- Building out assay development, automation, and data science teams to accelerate sample preparation, integration, and data interpretation.
- Targeting partnerships with pharmaceutical and diagnostic companies to apply the technology in drug target discovery and biomarker identification.

## Why Work Here
- **Mission-driven work**: Join a team aiming to create “the protein revolution” – solving one of biology’s hardest analytical challenges.
- **Growth opportunity**: Early-stage company with strong funding traction; employees can shape foundational processes and technology.
- **Culture**: Career page describes hiring “exceptional candidates motivated by solving complex, meaningful problems.” Office-first culture based in Berkeley, CA (3100 San Pablo Ave).
- **Compensation**: Listed salary ranges (e.g., $112K–$257K for scientist roles) are competitive for the Bay Area biotech market.
- **Team composition**: Highly specialized R&D team (37% research, 17% technical) with significant senior/specialist talent; opportunity to work with experienced biotech leaders.
- **Open roles** (8 active postings): Director of Data Science, Staff Scientist (Bioconjugation, Automation, Chemistry), Assay Integration Lead, Head of Automation, and more.

## Sources
1. [glyphic.bio](https://glyphic.bio/)
2. [Greenhouse Job Board](http://job-boards.greenhouse.io/glyphicbiotechnologies)
3. [LinkedIn Company Page](https://www.linkedin.com/company/glyphicbio)
4. [CB Insights Profile](https://www.cbinsights.com/company/glyphic-biotechnologies)
5. [Workable Jobs](https://apply.workable.com/glyphicbio/?lng=en)

## Other roles at Glyphic Biotechnologies

- [Scientist / Senior Scientist, Multiomics Applications](https://feeny.ai/job/scientist-senior-scientist-multiomics-applications-glyphic-biotechnologies-dynz6s08xyq8) — Berkeley, CA
- [Staff / Senior Scientist, Assay Development (Chemistry)](https://feeny.ai/job/staff-senior-scientist-assay-development-chemistry-glyphic-biotechnologies-44pypaxa4aj0) — Berkeley, CA
- [Scientist / Senior Scientist, Assay Development (Reagents)](https://feeny.ai/job/scientist-senior-scientist-assay-development-reagents-glyphic-biotechnologies-5sg3815tkr5z) — Berkeley, CA
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- [Data Infrastructure Engineer](https://feeny.ai/job/data-infrastructure-engineer-glyphic-biotechnologies-berkeley-6g06w8mh15kq) — Berkeley, CA