--- title: 'Senior Scientist, Analytical Development at Replimune' canonical: 'https://feeny.ai/job/senior-scientist-analytical-development-replimune-milton-park-z22kjsqck6ev' type: 'job' last_seen: '2026-09-09' --- # Senior Scientist, Analytical Development at Replimune - **Company:** Replimune - **Location:** Milton Park - **Employment:** full-time - **Work type:** onsite - **Posted:** 2026-07-20 - **Last confirmed live:** 2026-09-09 - **Apply:** https://jobs.ashbyhq.com/replimune/ca9a9bdf-78dc-4467-bec0-f4bad777d350 ## Job description ## Overview Replimune’s mission is to revolutionize cancer treatment with therapies designed to activate a powerful and durable full-body anti-tumor response, boldly transforming cancer care because patient’s lives depend on it. At Replimune, we live by our values: United: We Collaborate for a Common Goal. Audacious: We Are Bold. Dedicated: We Give Our Full Commitment. Candid: We Are Honest With Each Other. People are at the center of everything we do, and when it comes to our employees, we make it personal. With a deep sense of purpose, a strong and evolving culture, a competitive and forward-looking total rewards program, everyone at Replimune has a unique opportunity to impact on the lives of patients, caregivers and themselves. Join us, as we reshape the future. Summary of job description: Sr. Scientist Analytical Development is responsible for developing, optimizing, qualifying, and validating analytical methods based on new and existing methodologies to qualitatively and quantitatively evaluate both drug substance and drug product, from preclinical through late phase clinical development. Analytical development supports drug substance/drug product release, process development, and characterization and/or stability testing of Replimune’s clinical material. In addition, coordination of analytical development and analysis work at CMOs/CROs will be a significant portion of the duties of the Sr. Scientist Analytical Development. - This position is based in our Milton Park location and typically has a 5-day on-site expectation. Key responsibilities: - Manage the development, qualification and validation of analytical test methods and technology transfer in accordance with ICH and other regulatory guidances. - Support release and stability testing performed in house and at contract research organization (CRO), and directing good manufacturing practices (GMP) investigations including deviation root cause analyses, corrective action preventative action (CAPA), and out of specification (OOS). - Develop strategies for evaluating and implementing new technologies within Analytical Development. - Support process development, setting of specifications, and chemistry manufacturing and control (CMC) regulatory filings and responses. - Involved in daily workings of the group and actively participate in method troubleshooting and data analysis. Other responsibilities: - Supervise the work of Assay Development Scientists or Technicians - Analytical Development (AD) representative for cross function meetings/projects with manufacturing, Quality Assurance (QA), Regulatory Affairs and external partners. - Provide AD review and approval of SOPs, risk assessments, protocols and reports. - Provide regular updates of AD group activities to the Chief Operating Officer and other Replimune senior management. Educational requirements: Education will be appropriate to specific job requirements. The following educational requirements are a minimum: - B.A or B.S. degree in a relevant biological science. M.S., Ph.D. or other post-graduate degree in biochemistry or related science is preferred Experience and skill requirements: Training and experience will be appropriate to specific job requirements. The following categories will be assessed in each case: - 5-10 years industry experience, preferably in a cGMP Quality environment - Experience working in a GMP testing environment with an understanding of regulatory requirements and trends related to analytics and product development. - Thorough understanding of current regulatory requirements and practical experience of QC testing in support of cGMP operations - Ability to interface effectively with management and other groups or project teams - Computer processing literacy and experience in statistical analysis - Excellent verbal and written communication skills - Good organizational skills ## About Replimune Replimune Group, Inc., headquartered in Woburn, MA, was founded in 2015 with the mission to transform cancer treatment by pioneering the development of a novel portfolio of oncolytic immunotherapies. Replimune’s proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. The RPx product candidates are expected to be synergistic with most established and experimental cancer treatment modalities, leading to the versatility to be developed alone or combined with a variety of other treatment options. For more information, please visit www.replimune.com http://www.replimune.com. We are an Equal Opportunity Employer. ## About Replimune ## Company Overview - **One-liner**: Replimune is a clinical-stage biotech company focused on revolutionizing cancer treatment with a new class of oncolytic immunotherapies intended to activate a powerful and durable full-body anti-tumor response. - **Entity Type**: Public (ticker not explicitly provided in search results, but company is publicly traded) - **Headquarters**: Framingham, Massachusetts, USA (with additional locations in Woburn, MA and Oxfordshire, UK) - **Founded**: 2015 - **Founders**: Robert Coffin, Ph.D. (Founder and Chief Scientist) ## Core Business - **Primary industry**: Biotechnology – oncology, oncolytic immunotherapy - **Target customers**: B2B (pharmaceutical partners) and ultimately patients through healthcare providers - **Mission**: To ignite a systemic immune response to cancer and reshape the future of cancer care ## Products & Services - **RPx Platform**: Proprietary, next-generation HSV-1-based oncolytic immunotherapy platform that powers all pipeline candidates. - **RP1**: Investigational oncolytic immunotherapy for advanced melanoma (IGNYTE trial, PDUFA date April 10, 2026) and non-melanoma skin cancers; also being studied as monotherapy in organ transplant patients with skin cancer (ARTACUS trial). - **RP2**: Investigational oncolytic immunotherapy for metastatic uveal melanoma (Phase 2/3 RP2-202 trial) and hepatocellular carcinoma (Phase 2 in combination with atezolizumab/bevacizumab). ## Market Standing - **Valuation/Market Cap**: Not publicly available in provided sources - **Key Metric**: Clinical-stage; no approved products yet. Key regulatory milestone: FDA action date for RP1 in advanced melanoma on April 10, 2026. - **Notable Partners**: Bristol-Myers Squibb (supply of nivolumab), Roche (supply of atezolizumab and bevacizumab) – Replimune retains full commercial rights. - **Growth Signals**: Completed enrollment in IGNYTE trial; confirmatory IGNYTE-3 trial underway; own 63,000 sq ft U.S. manufacturing facility in Woburn, MA enabling global commercial supply; broad pipeline across multiple solid tumor indications. ## Competitive Advantages - **Strong IP position**: Wholly-owned, unencumbered RPx platform with broad patent protection. - **In-house manufacturing**: Dedicated U.S. facility for commercial-scale production, reducing reliance on contract manufacturers. - **First-mover potential**: Poised to be one of the first oncolytic immunotherapies to reach the market if RP1 gains FDA approval. - **Full rights retained**: All partnership agreements allow Replimune to keep full commercial rights to its therapies. ## Strategic Focus - Advancing RP1 toward FDA approval in advanced melanoma (April 2026 PDUFA date) - Expanding pipeline into additional indications (uveal melanoma, hepatocellular carcinoma, non-melanoma skin cancers) - Building out commercial infrastructure and manufacturing capabilities - Exploring combination therapies with checkpoint inhibitors (nivolumab, atezolizumab) ## Why Work Here - **Culture**: Cross-functional, collaborative, values-driven environment. Employee survey results show 92% proud to work at Replimune, 88% feel they make a positive difference, 78% would recommend the company. - **Flexibility**: Hybrid and remote work options available depending on role; home office and mobile phone stipend provided. - **Compensation**: New hire equity grants, generous annual bonus plans, retirement plans with substantial company match (100% vested from day one). - **Benefits**: Medical, dental, and vision insurance 100% paid by the company. - **Locations**: U.S. (Woburn, MA and Framingham, MA) and UK (Oxfordshire) – opportunities to work across both sites. ## Sources 1. [Replimune Homepage](https://www.replimune.com/) 2. [Replimune Careers](https://www.replimune.com/careers) 3. [Replimune About Us](https://www.replimune.com/about-us) 4. [Replimune Team](https://www.replimune.com/team) 5. [Replimune Pipeline](https://www.replimune.com/pipeline) ## Other roles at Replimune - [Director, HR Business Partner](https://feeny.ai/job/director-hr-business-partner-replimune-milton-park-z5a3s7k1jy7g) — Milton Park - [Executive Director, Market Access and Value](https://feeny.ai/job/executive-director-market-access-and-value-replimune-woburn-nf352x5v48bh) — Woburn, MA - [Scientist II, Quality Control](https://feeny.ai/job/scientist-ii-quality-control-replimune-framingham-sf1y1pmqxbjw) — Framingham, MA - [Senior Manager, Data Management](https://feeny.ai/job/senior-manager-data-management-replimune-woburn-kesxh7s9ktmd) — Woburn, MA - [Operational Excellence Lead I (PharmD)](https://feeny.ai/job/operational-excellence-lead-i-pharmd-replimune-woburn-xt9zv5h9hb19) — Woburn, MA - [Senior Strategic Account Manager - Omaha](https://feeny.ai/job/senior-strategic-account-manager-omaha-replimune-woburn-zd29jhn75tz0) — Woburn, MA - [Manufacturing Associate I](https://feeny.ai/job/manufacturing-associate-i-replimune-framingham-a9c083cyq8ms) — Framingham, MA - [Manufacturing Technician](https://feeny.ai/job/manufacturing-technician-replimune-framingham-b4s89qjyc580) — Framingham, MA - [Sr. Scientist, Process Development & Technology](https://feeny.ai/job/sr-scientist-process-development-technology-replimune-framingham-h5fn33dyrqr9) — Framingham, MA - [Manager, Regulatory Operations (Publishing)](https://feeny.ai/job/manager-regulatory-operations-publishing-replimune-woburn-pjc393jvsvg4) — Woburn, MA