---
title: 'Senior Scientist, Antibody Conjugation at Nurix'
canonical: 'https://feeny.ai/job/senior-scientist-antibody-conjugation-nurix-brisbane-7jgym161pa4f'
type: 'job'
last_seen: '2026-09-09'
---

# Senior Scientist, Antibody Conjugation at Nurix

- **Company:** Nurix
- **Location:** Brisbane, CA
- **Posted:** 2026-07-16
- **Last confirmed live:** 2026-09-09
- **Apply:** https://job-boards.greenhouse.io/nurix/jobs/8635664002

## Job description

Senior Scientist, Antibody Conjugation

## About the Role

We are growing the team with a hands-on antibody conjugation scientist who will build this capability from the ground up by developing and validating bioconjugation chemistries that are reproducible at bench scale, sufficiently robust for transfer to automated higher-throughput synthesis workflows, and scalable for preparation campaigns supporting advanced in vivo and translational studies.

This is a lab-based role for someone who wants to build a new technical capability inside an established, highly collaborative discovery organization and partner closely with medicinal chemistry, analytical chemistry, computational chemistry, protein biochemistry, and automation to move candidates from bench to study-ready material.

## What You'll Do

- Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
- Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
- Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines.
- Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise.
- Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently.
- Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed.
- Stay current on emerging bioconjugation and DAC/ADC methodology and bring forward new techniques relevant to Nurix's pipeline.

## Who You Are

- A team player who works well across disciplines (chemistry, analytical, protein biochemistry, automation/engineering) and communicates clearly with both scientists and technical staff.
- Results-oriented: you drive a method from first attempt to a robust, transferable protocol, and you personally deliver material when a study needs it.
- Comfortable owning a technical area with real autonomy in a growing capability area.

## Qualifications

- PhD in chemistry, biochemistry, chemical biology, or a related field preferred; MS or BS with substantial (8+ for BS/MS) hands-on industry bioconjugation experience will also be considered.
- Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.
- Experience purifying and characterizing conjugates: FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis.
- Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team.
- Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization

## Why This Role

You'll be the founding technical expert for antibody conjugation at Nurix, shaping both the science and how it's automated and scaled — with direct visibility to program leadership and a fast path from method development to real studies

Salary Range:  $174,900 - $185,200 plus bonus and equity

Fit with Nurix Culture and Values

- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view

We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

## About Nurix

## Company Overview
- **One-liner**: Nurix Therapeutics is a clinical-stage biopharmaceutical company pioneering targeted protein degradation medicines to outmatch disease by harnessing the cell’s natural protein disposal system.
- **Entity Type**: Public (NASDAQ: NRIX)
- **Headquarters**: San Francisco, California, USA
- **Founded**: 2009
- **Founders**: Not publicly listed as individual founders; the company was spun out from research at UC Berkeley and UC San Francisco.

## Core Business
- **Primary industry**: Biopharmaceuticals / Targeted Protein Degradation
- **Target customers**: B2B (pharma partners) and B2C (patients via clinical trials and eventual commercial therapies); enterprise-level partnerships with major pharma.
- **Mission or purpose statement**: "Writing medicine’s next chapter using targeted protein degradation as a new script to outmatch disease." [nurixtx.com](https://www.nurixtx.com/)

## Products & Services
- **Bexobrutideg (NX-5948)**: A potential best-in-class BTK degrader in Phase 1b/2 clinical trials for relapsed/refractory CLL/SLL and chronic spontaneous urticaria. Co-developed and co-commercialized with Roche under a global collaboration announced June 2026. [nurixtx.com](https://www.nurixtx.com/)
- **NX-2127**: A BTK degrader in clinical development for B-cell malignancies.
- **CBL-B Inhibitor (NX-1607)**: An E3 ligase inhibitor designed to activate T cells for immuno-oncology, in Phase 1 clinical trials.
- **IRAK4 Degrader**: A partnered program with Gilead in Phase 1 for inflammatory diseases.
- **STAT6 Degrader**: A partnered program with Sanofi in IND-enabling studies.
- **DEL-AI Discovery Engine**: A proprietary, fully AI-integrated platform combining DNA-encoded libraries (DEL), automated chemistry, and machine learning to design and optimize targeted protein degraders and degrader-antibody conjugates (DACs).

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the provided search results; as a public company (NRIX), market cap fluctuates daily. Check financial platforms for the latest figure.
- **Key Metric**: Annual Revenue (public) — Not publicly available in the provided search results; as a clinical-stage biotech, revenue is typically minimal or pre-revenue. Total funding raised prior to IPO is not detailed in the provided results.
- **Notable Investors/Partners**: Roche (global co-development and co-commercialization collaboration for bexobrutideg, announced June 2026), Gilead (partnered IRAK4 degrader program), Sanofi (partnered STAT6 degrader program).
- **Growth Signals**: Announced a landmark global collaboration with Roche in June 2026 to co-develop and co-commercialize bexobrutideg across malignant hematology, immunology, and neurology. Presented positive Phase 1a/b data for bexobrutideg in CLL/SLL and chronic spontaneous urticaria in 2026. Multiple partnered and wholly owned pipeline programs advancing through clinical and preclinical stages.

## Competitive Advantages
- **Proprietary DEL-AI Discovery Engine**: A fully AI-integrated platform combining DNA-encoded libraries, automated chemistry, and machine learning to design degraders against any protein class, providing a significant speed and innovation advantage. [nurixtx.com](https://www.nurixtx.com/)
- **Unparalleled Ligase Expertise**: Deep understanding of E3 ligase biochemistry and biology, a critical and complex component of the protein degradation mechanism, giving them a unique moat.
- **Multi-Modal Pipeline**: Developing both small molecule degraders and Degrader-Antibody Conjugates (DACs), expanding the therapeutic reach and creating multiple shots on goal.
- **Strong Partnership Network**: Collaborations with top-tier pharma (Roche, Gilead, Sanofi) validate their platform and provide non-dilutive funding and shared risk.

## Strategic Focus
- **Clinical Advancement**: Driving lead asset bexobrutideg through pivotal trials in CLL/SLL and expanding into immunology (chronic spontaneous urticaria) and neurology.
- **Platform Expansion**: Leveraging the DEL-AI engine to develop Degrader-Antibody Conjugates (DACs) for enhanced cell specificity and safety.
- **Pipeline Breadth**: Advancing a multi-modal pipeline across oncology, immunology, and neurology, both wholly owned and through strategic partnerships.
- **Partnership Leverage**: Deepening collaborations with Roche, Gilead, and Sanofi to co-develop and co-commercialize programs, reducing risk and accelerating timelines.

## Why Work Here
- **Culture**: Mission-focused, values-based, and spirited culture emphasizing "breakthrough innovation," "leadership," "accountability," and "zealousness." Employees are encouraged to "think big and act bold." [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Work with Industry Leaders**: The team includes scientific innovators who built the protein degradation field, seasoned executives with biotech scaling expertise, and leading clinicians. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Growth & Impact**: Employees can "wear many hats" and gain broad exposure in a lean, virtual drug developer environment. The company emphasizes career growth and opportunity-rich experiences.
- **Work Policy**: Onsite in Brisbane, CA (San Francisco Bay Area) for most roles, as indicated by job postings. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)
- **Benefits**: Comprehensive health and welfare plans, enhanced parental leave, wellness reimbursement, 401(k) employer match, and a highly collaborative culture. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Engineering/Science Culture**: Described as "mission-focused, values-based, and spirited," with a focus on "intellectual and technical ingenuity" and "intelligent risk-taking." The company is a "virtual drug developer" with a lean internal infrastructure, relying on SaaS and cloud platforms. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)

## Sources
1. [nurixtx.com](https://www.nurixtx.com/)
2. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
3. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)
4. [nurixtx.com](https://www.nurixtx.com/our-story/)

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