--- title: 'Senior Scientist, Biochemistry at Quantum-Si' canonical: 'https://feeny.ai/job/senior-scientist-biochemistry-quantum-si-branford-2rkwb7sjyv0v' type: 'job' last_seen: '2026-10-28' --- # Senior Scientist, Biochemistry at Quantum-Si - **Company:** Quantum-Si - **Location:** Branford, CT - **Posted:** 2026-10-20 - **Last confirmed live:** 2026-10-28 - **Apply:** https://job-boards.greenhouse.io/quantumsi25/jobs/6229579004 ## Job description The Senior Scientist, Biochemistry will lead development and implementation of high-throughput biochemical assays to discover and characterize aminopeptidases with properties relevant to next-generation protein sequencing. The role will focus on screening diverse aminopeptidase candidates for activity, selectivity, kinetics, robustness, and performance across a broad range of substrates. The successful candidate will combine strong expertise in enzymology, protein biochemistry, assay development, and quantitative data analysis to advance enzyme reagents. Core Responsibilities - Develop workflows and progression criteria for primary screening, hit confirmation, characterization, ranking, and advancement of enzyme candidates. - Integrate screening assays into enzyme-evolution pipelines and coordinate the advancement of promising candidates into downstream development and sequencing-assay evaluation. - Develop clear, reusable reporting tools to communicate screening results, candidate recommendations, and pipeline status. - Purify and characterize proteins to support assay development and candidate evaluation. - Use laboratory automation and data-analysis tools to increase screening throughput, consistency, and traceability. - Contribute to a culture of scientific rigor, execution, continuous learning, and knowledge sharing. - Document and transfer selected assays to downstream QC teams to support the release of production enzymes. Required Qualifications - M.S. with 7+ years or Ph.D. with 3+ years of relevant academic or industry experience in protein biochemistry, enzymology, biophysics, biotechnology, chemical biology, or a related field. - Demonstrated ability to independently and creatively design, optimize, and troubleshoot biochemical assays for challenging enzymology applications. - Strong foundation in enzyme kinetics, protein-substrate interactions, assay controls, and quantitative interpretation of biochemical data. - Experience developing enzyme-activity assays using fluorescence, absorbance, polarization, chromatography, or related readouts. - Ability to analyze large experimental datasets and use computational or statistical tools to support assay optimization and candidate selection. - Ability to learn, set up, and operate complex instrumentation and laboratory automation. - Ability to plan and execute multiple scientific workstreams while maintaining high standards for experimental design, documentation, and data quality. - Excellent organizational, analytical, communication, collaboration, and presentation skills. ## Preferred Qualifications - Experience developing and scaling high-throughput enzyme-screening workflows, including assay miniaturization and automation. - Expertise in aminopeptidases, proteases, exopeptidases, or other proteolytic enzymes. - Experience evaluating enzyme activity across diverse peptide substrates and sequence contexts. - Experience with rapid-kinetics methods and instrumentation, including stopped-flow or quench-flow systems. - Hands-on experience with protein expression, purification, and characterization using chromatography systems such as AKTA and HPLC. - Experience with fluorescence polarization, fluorimeters such as Fluoromax, LC-MS, or other orthogonal methods for enzyme characterization. - Experience with peptide synthesis, peptide conjugation, protein labeling, or single-molecule assay development. - Experience with labeling and evaluation of proteins using ensemble and single-molecule assays. The estimated base salary range for this position in the United States is $135,000- $165,000. In addition to base salary, full-time employees are eligible to participate in Quantum-Si's discretionary annual bonus program and may receive equity awards as part of the total compensation package. Actual compensation will be determined based on a variety of factors, including, but not limited to, the position level, relevant skills, knowledge, experience, qualifications, geographic location, internal equity, and market data. Quantum-Si also offers a competitive benefits package designed to support employees' health, well-being, work-life balance, and family needs. Benefits include: - Comprehensive medical, dental, and vision insurance coverage - Health Savings Account (HSA) and Flexible Spending Account (FSA) options, where applicable - Company-paid life and accidental death & dismemberment (AD&D) insurance - Short-term and long-term disability coverage - Employee Assistance Program (EAP) resources to support personal and professional well-being - Discretionary paid time off and company-paid holidays - Parental leave to support employees welcoming and caring for a new child - 401(k) retirement savings plan with both pre-tax and Roth contribution options Additional Information Candidates must be authorized to work in the United States. Quantum-Si does not provide employment-based immigration sponsorship of any kind for this position, including support for applicants currently pursuing permanent residency (Green Card sponsorship). Quantum-Si does not accept unsolicited agency resumes. Quantum-Si is an E-Verify and equal opportunity employer regardless of race, color, ancestry, religion, gender, national origin, sexual orientation, age, citizenship, marital status, disability or Veteran status. All your information will be kept confidential according to EEO guidelines ## About Quantum-Si ## Company Overview - **One-liner**: Quantum-Si is pioneering the post-genomic era by making single-molecule protein sequencing accessible through its benchtop Platinum and Platinum Pro instruments. - **Entity Type**: Public (NASDAQ: QSI) - **Headquarters**: Branford, Connecticut, United States - **Founded**: 2013 - **Founders**: Jonathan Rothberg ## Core Business - **Primary industry**: Biotechnology Research / Life Sciences Tools (Proteomics) - **Target customers**: B2B; academic research labs, pharmaceutical and biotechnology companies, core facilities, and drug development organizations. - **Mission or purpose statement**: To power the post-genomic era of biology by making next-generation protein sequencing (NGPS) accessible to every lab, everywhere, enabling breakthroughs in drug discovery, diagnostics, and human health. ## Products & Services - **Platinum® Pro**: An advanced benchtop next-gen protein sequencer (NGPS) delivering single-molecule resolution with real-time kinetic insights. It features a simplified workflow (less than three hours of hands-on time), a user-friendly touchscreen interface, and flexible data analysis (local or cloud-based). Designed for variant detection, protein identification, and post-translational modification (PTM) analysis. - **Platinum®**: The world’s first next-gen protein sequencing instrument, enabling single-molecule, single-amino-acid resolution for proteomics research. - **Proteus™ Platform**: A next-generation platform (announced in partnership with Cell Signaling Technology) focused on advancing post-translational modification (PTM) analysis. - **Protein Barcoding**: A solution for simultaneously characterizing multiple protein variants, increasing throughput for screening and therapeutic development, including applications in drug delivery (LNPs, AAV capsids) and antibody characterization. ## Market Standing - **Valuation/Market Cap**: $109.7 million (as of mid-2026) [linkedin.com] - **Key Metric**: Annual Revenue of $2.4 million (public company) [linkedin.com] - **Total Funding**: $1.065 billion (including post-IPO equity rounds) [linkedin.com] - **Notable Investors/Partners**: HighCape Capital Acquisition Corp (parent), Cell Signaling Technology (strategic partner for PTM analysis), 4Catalyzer (affiliated incubator). - **Growth Signals**: - Publicly traded on NASDAQ (QSI) since June 2021. - Announced a strategic partnership with Cell Signaling Technology in June 2026 to advance PTM analysis on the Proteus platform [quantum-si.com]. - Expanding commercial presence with a roadshow for the Proteus platform [quantum-si.com]. - Named "2023 Proteomics Company of the Year" and "Innovation by Design 2023" [quantum-si.com]. - Active hiring for senior commercial and field roles, indicating a push to scale go-to-market. ## Competitive Advantages - **First-mover in NGPS**: Quantum-Si is the first company to bring a next-generation protein sequencing (NGPS) platform to market, offering single-molecule resolution that traditional mass spectrometry and Edman degradation cannot achieve. - **Simplified Workflow**: The platform requires less than three hours of hands-on time and no dedicated lab space or specialized expertise, making advanced proteomics accessible to a broader range of labs. - **Unique Kinetic Profiling**: Uses real-time, single-molecule kinetic signatures to detect protein variants, post-translational modifications, and proteoforms, providing deeper functional insights than antibody-based or mass-spec methods. - **Integrated AI**: Blends biology, chemistry, and artificial intelligence to drive data analysis and interpretation. ## Strategic Focus - **Commercial Expansion**: Scaling the commercial team (hiring field application scientists, service engineers, and business development managers) to drive adoption of the Platinum and Proteus platforms globally. - **Partnership Development**: Deepening collaborations with key players like Cell Signaling Technology to expand applications in PTM analysis and drug development. - **Platform Evolution**: Advancing the Proteus platform and expanding the protein barcoding solution for high-throughput screening in therapeutic development (e.g., LNPs, AAV capsids). - **Market Penetration**: Moving beyond early adopters to broader academic and pharmaceutical markets, with a focus on making proteomics accessible without dedicated lab space or specialized expertise. ## Why Work Here - **Culture**: Described as dynamic, collaborative, and purpose-driven, with a focus on innovation and solving complex scientific challenges. Values include "Never Settle," "Embrace Change," "Succeed Together," "Stand Up," and "Speak Up" [quantum-si.com]. - **Mission-Driven**: Employees are motivated by the potential to transform human health and make a global impact through accessible protein sequencing. - **Benefits & Perks**: 100% fully covered medical/dental/vision, generous HSA contribution on HDHP, 401K plan, generous parental leave, flexible paid time off, short/long-term disability, and company-sponsored life insurance [quantum-si.com]. - **Equity**: 100% of employees are stakeholders, aligning team members with company success. - **Work Environment**: Dynamic and collaborative culture. Roles are a mix of on-site (San Diego, CA; Branford, CT) and remote (e.g., Field Application Scientist, Northwest AMR). The company emphasizes transparency, adaptability, and a purpose-driven mission. - **Headcount**: 153 employees, with a +1.6% YoY growth. The team is primarily US-based (75%) with a presence in France, UK, Germany, Spain, Belgium, and Singapore [linkedin.com]. ## Sources 1. [quantum-si.com](https://www.quantum-si.com/) 2. [quantum-si.com/about](https://www.quantum-si.com/about/) 3. [quantum-si.com/careers](https://www.quantum-si.com/about/careers/) 4. [linkedin.com/company/quantum-si](https://www.linkedin.com/company/quantum-si) 5. [job-boards.greenhouse.io/quantumsi25](https://job-boards.greenhouse.io/quantumsi25) ## Other roles at Quantum-Si - [Senior Field Service Engineer](https://feeny.ai/job/senior-field-service-engineer-quantum-si-san-diego-m1th43gh7htw) — San Diego, CA - [Sr. Manager of Supply Chain Logistics](https://feeny.ai/job/sr-manager-of-supply-chain-logistics-quantum-si-san-diego-b5vgbakpkj89) — San Diego, CA - [Senior Scientist, Systems Integration](https://feeny.ai/job/senior-scientist-systems-integration-quantum-si-san-diego-4k647tgxqc6j) — San Diego, CA - [Senior Field Application Scientist, Northwest AMR](https://feeny.ai/job/senior-field-application-scientist-northwest-amr-quantum-si-remote-fxx1xdk00me5)