---
title: 'Senior Scientist I, Biotherapeutic Production Technologies at Generate Biomedicines'
canonical: 'https://feeny.ai/job/senior-scientist-i-biotherapeutic-production-technologies-generate-biomedicines-bv9g98d0ty9p'
type: 'job'
last_seen: '2026-09-11'
---

# Senior Scientist I, Biotherapeutic Production Technologies at Generate Biomedicines

- **Company:** Generate Biomedicines
- **Location:** Andover, MA
- **Compensation:** $125k–$175k
- **Posted:** 2026-09-01
- **Last confirmed live:** 2026-09-11
- **Apply:** https://generatebiomedicines.com/open-positions?gh_jid=4710188006

## Job description

The Role:

Location:  Andover, MA

Generate:Biomedicines is seeking an experienced Senior Scientist I to independently lead complex protein production and characterization efforts in support of drug discovery and platform initiatives.

This individual-contributor role will work across upstream construct and expression strategy, mammalian and cell-free protein production, downstream purification, and fit-for-purpose analytical characterization. You will define technical approaches, integrate data acrossworkflows, and make recommendations that enable confident scientific decisions across multiple protein modalities and stages of work.

You will serve as a technical point of contact for protein purification and characterization strategy, partnering with cross-functional teams and external collaborators to align material quality, scale, timelines, and downstream requirements. You will also help advance scalable, data-rich workflows that improve throughput, reproducibility, and organizational learning.

Here's how you will contribute:

- Independently define, plan, and execute complex protein production, purification, and characterization strategies across multiple discovery and platform initiatives. Establish technical milestones, decision criteria, dependencies, and risk-mitigation plans.
- Lead the design, optimization, scale-up, and troubleshooting of protein expression workflows, including transient mammalian and cell-free protein synthesis platforms. Provide technical input into construct design, molecular biology, and stable-expression activities as needed.
- Lead purification workflow development from capture through polishing, with particular emphasis on larger-scale or later-stage protein production. Design and interpret chromatography screening studies, including predictor-plate approaches, resin selection, operating-condition optimization, and scale translation.
- Produce high-quality protein material across a range of formats and scales. Partner with downstream stakeholders to establish fit-for-purpose quality attributes and acceptance criteria based on intended use.
- Select, apply, and interpret appropriate analytical and biochemical characterization methods to assess protein purity, identity, concentration, oligomeric state, aggregation, stability, and other relevant quality attributes.
- Integrate expression, purification, and characterization data to identify root causes, resolve complex technical challenges, evaluate trade-offs, and recommend next steps. Clearly communicate the evidence, assumptions, risks, and uncertainty supporting technical decisions.
- Serve as a technical point of contact for protein production, purification, and characterization strategy. Influence cross-functional decisions by translating scientific findings into clear recommendations for discovery, platform, analytical, and data-focused partners.
- Lead technical interactions with CROs, CDMOs, vendors, and other external partners as appropriate, including defining technical work packages, supporting method or process transfer, reviewing data, troubleshooting issues, and ensuring that deliverables meet scientific requirements.
- Drive the development of scalable, reproducible, and well-documented workflows. Advance the thoughtful use of automation, high-throughput approaches, structured experimental data, and AI/ML-enabled tools to improve scientific productivity and learning.
- Develop and share new methods, technical standards, and best practices. Advise and mentor colleagues, provide constructive scientific feedback, and contribute to an inclusive, collaborative, and high-performing team.
- Demonstrate accountability for scientific quality and delivery by tracking progress, proactively surfacing risks, and communicating successes, setbacks, and lessons learned with clarity and transparency.

The Ideal Candidate will have:

- Independently define, plan, and execute complex protein production, purification, and characterization strategies across multiple discovery and platform initiatives. Establish technical milestones, decision criteria, dependencies, and risk-mitigation plans.
- Lead the design, optimization, scale-up, and troubleshooting of protein expression workflows, including transient mammalian and cell-free protein synthesis platforms. Provide technical input into construct design, molecular biology, and stable-expression activities as needed.
- Lead purification workflow development from capture through polishing, with particular emphasis on larger-scale or later-stage protein production. Design and interpret chromatography screening studies, including predictor-plate approaches, resin selection, operating-condition optimization, and scale translation.
- Produce high-quality protein material across a range of formats and scales. Partner with downstream stakeholders to establish fit-for-purpose quality attributes and acceptance criteria based on intended use.
- Select, apply, and interpret appropriate analytical and biochemical characterization methods to assess protein purity, identity, concentration, oligomeric state, aggregation, stability, and other relevant quality attributes.
- Integrate expression, purification, and characterization data to identify root causes, resolve complex technical challenges, evaluate trade-offs, and recommend next steps. Clearly communicate the evidence, assumptions, risks, and uncertainty supporting technical decisions.
- Serve as a technical point of contact for protein production, purification, and characterization strategy. Influence cross-functional decisions by translating scientific findings into clear recommendations for discovery, platform, analytical, and data-focused partners.
- Lead technical interactions with CROs, CDMOs, vendors, and other external partners as appropriate, including defining technical work packages, supporting method or process transfer, reviewing data, troubleshooting issues, and ensuring that deliverables meet scientific requirements.
- Drive the development of scalable, reproducible, and well-documented workflows. Advance the thoughtful use of automation, high-throughput approaches, structured experimental data, and AI/ML-enabled tools to improve scientific productivity and learning.
- Develop and share new methods, technical standards, and best practices. Advise and mentor colleagues, provide constructive scientific feedback, and contribute to an inclusive, collaborative, and high-performing team.
- Demonstrate accountability for scientific quality and delivery by tracking progress, proactively surfacing risks, and communicating successes, setbacks, and lessons learned with clarity and transparency.

Education and Experience

- Ph.D. in biochemistry, molecular biology, bioengineering, chemical engineering, protein sciences, or a related discipline, with typically 4 or more years of relevant industry experience; or B.S. or M.S. in a relevant scientific or engineering discipline, with typically 12 or more years of relevant industry experience; or An equivalent combination of education and experience that demonstrates the technical depth, independent judgment, and scope of impact required for the role.

## Nice to Have

- Experience with stable-expression systems and stable cell-line development activities.
- Experience with construct design, cloning, vector design, or related molecular-biology workflows.
- Experience working with engineered proteins, multispecifics, novel scaffolds, or other complex protein modalities.
- Experience integrating protein design information into expression, purification, or characterization strategies.
- Experience with automation, high-throughput experimentation, laboratory information systems, or structured experimental-data environments.
- Experience managing technical work conducted by CRO, CDMO, or vendor partners.
- Experience developing workflows or methods that were adopted beyond an immediate project or work group.

Who Will Love This Job:

This is an opportunity to shape how Generate produces, characterizes, and learns from protein material in a modern, data-rich discovery environment. Your work will directly influence critical scientific decisions while improving the speed, quality, scale, and reproducibility of workflows used across discovery and platform initiatives.

You will combine hands-on science with meaningful technical ownership, broad cross-functional collaboration, and the opportunity to develop approaches that enable the advancement of next-generation biologics.

## About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

## #LI-RT1

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range $125,000—$175,000 USD

## About Generate Biomedicines

## Company Overview
- **One-liner**: Generate Biomedicines is a clinical-stage generative biology company pioneering the use of machine learning to design and develop protein-based medicines on demand.
- **Entity Type**: Public (ticker: GBIO)
- **Headquarters**: Somerville, Massachusetts, USA (Boynton Yards and Andover locations)
- **Founded**: 2018
- **Founders**: Gevorg Grigoryan, Daria Hazuda, and others

## Core Business
- **Primary industry**: Biotechnology / Drug Discovery & Development
- **Target customers**: B2B (pharmaceutical partners) and patients (via clinical programs)
- **Mission statement**: "We don’t discover medicines—we design them," with a belief that speed is a moral obligation to patients.

## Products & Services
- **[Generate Platform™]**: An integrated computational and biohardware innovation stack that uses generative biology to design proteins with defined biological intent. It can generate up to a billion designed variants per cycle with cycle times as fast as ~8 days.
- **[GB-0895 (Anti-TSLP Antibody)]**: A next-generation anti-TSLP monoclonal antibody for severe asthma and COPD, currently in global Phase 3 trials. Designed for ultra-high affinity (106 fM binding, 20x improvement over tezepelumab) and an extended half-life (98 days, longest known among TSLP-targeting therapies), enabling twice-yearly subcutaneous dosing.
- **[GB-5267 (MUC-16 Armored CAR-T)]**: A cell therapy candidate for metastatic ovarian cancer, expected to enter Phase 1 in 1H26.
- **[GB-4362 (Free MMAE Toxin Neutralizer)]**: A first-in-class neutralizer designed for combination with MMAE-based antibody-drug conjugates (ADCs), with Phase 1 initiation in bladder cancer expected 1H26.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed; IPO in February 2026 raised net proceeds of approximately $370 million.
- **Key Metric**: $221.5 million cash balance at YE 2025, plus ~$370 million from IPO (early 2026).
- **Notable Investors/Partners**: Strategic collaborations with Amgen, Novartis, MD Anderson Cancer Center, and Roswell Park Comprehensive Cancer Center.
- **Growth Signals**: 5 clinical-stage programs enabled by the platform; initiated global Phase 3 studies for GB-0895; operating out of 140k+ square feet of lab and office space; has studied millions of proteins and generated 42,000 proteins built and tested.

## Competitive Advantages
- **Fully integrated computational-biohardware loop**: Machine learning drives generative design, which feeds directly into high-throughput experimentation (including proprietary CryoEM with four of the best microscopes in the world), and results continuously train the AI system — a "living feedback loop" that compounds over time.
- **Multimodal platform**: Can generate candidates across antibodies, CAR-T, and other protein modalities from a single core technology, enabling a pipeline that covers both immunology and oncology.
- **Record speed and scale**: Capable of generating up to a billion designed variants in ~8-day cycles, dramatically reducing the time and cost traditionally associated with drug discovery.
- **First-mover in next-gen anti-TSLP**: First known next-generation anti-TSLP antibody to enter the clinic (GB-0895) with a differentiated half-life profile that could enable twice-yearly dosing, a significant competitive edge in a large market.

## Strategic Focus
- **Clinical execution**: Advancing GB-0895 through global Phase 3 trials in severe asthma (with data in 2H27/1H28) and initiating late-stage development in COPD.
- **Pipeline expansion**: Moving GB-5267 (CAR-T) and GB-4362 (ADC neutralizer) into Phase 1 in 2026, expanding the platform's therapeutic scope.
- **Platform scaling**: Continuing to refine the generative biology engine to unlock new modalities and therapeutic areas, while deepening existing strategic collaborations with major pharma partners.
- **Organizational growth**: Building out the team across computational, wet-lab, clinical, and operational functions to support the growing pipeline.

## Why Work Here
- **Mission-driven**: The company is explicit that "speed is not just a competitive advantage—it’s a moral obligation." Employees are directly involved in designing drugs rather than discovering them, with a focus on getting treatments to patients faster.
- **Interdisciplinary culture**: The company emphasizes true integration across machine learning, biological engineering, and medicine. As stated on their site, "We are a close-knit group of cross-disciplinary experts... each conversant in one another’s fields, working together to create a new one."
- **Cutting-edge technology**: Access to unique computational and biohardware infrastructure, including "the four best CryoEM microscopes in the world" and a high-throughput experimental loop that powers AI training in real-time.
- **Values-driven leadership**: Explicit leadership behaviors include "value the knowledge we gain more than the knowledge we have," "bring creativity, tenacity, and ingenuity to every challenge," and "hold oneself and others to an obligation to dissent."
- **Hybrid/office policy**: Not explicitly stated, but the company operates large physical facilities in Somerville and Andover, MA, and offers free parking, monthly subway passes, or subsidized commuter rail passes, suggesting a significant on-site expectation.
- **Comprehensive benefits**: Competitive pay, employee stock option plan, health/vision/dental insurance, long- and short-term disability, life insurance, EAP, retirement savings, paid parental/adoption/caregiver leave, free weekly lunch, and stocked kitchen.
- **Growth trajectory**: As a newly public company with a cash-rich balance sheet and multiple catalysts over the next 12–24 months, the company offers significant career growth potential for those who want to be part of building a "transcendent company" that redefines an industry.

## Sources
1. [generatebiomedicines.com](https://generatebiomedicines.com/)
2. [generatebiomedicines.com/careers](https://generatebiomedicines.com/careers)
3. [generatebiomedicines.com/about-us](https://generatebiomedicines.com/about-us)
4. [investors.generatebiomedicines.com](https://investors.generatebiomedicines.com/)
5. [Non-Confidential Overview (April 2026)](https://investors.generatebiomedicines.com/wp-content/uploads/2026/04/Generate-Biomedicines-Non-Confidential-Overview_April-2026-1.pdf)

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