---
title: 'Senior Scientist I, Data Science at Sail Biomedicines'
canonical: 'https://feeny.ai/job/senior-scientist-i-data-science-sail-biomedicines-cambridge-sb4vx0r1ga9s'
type: 'job'
last_seen: '2026-09-12'
---

# Senior Scientist I, Data Science at Sail Biomedicines 

- **Company:** Sail Biomedicines 
- **Location:** Cambridge, MA
- **Posted:** 2026-06-01
- **Last confirmed live:** 2026-09-12
- **Apply:** https://job-boards.greenhouse.io/sendabiosciences/jobs/8573218002

## Job description

The Position

Join our team and drive the future of programmable eRNATM therapeutics and In Vivo CAR-T therapies- where AI-driven biology, targeted delivery systems and next-generation immunotherapy converge to redefine what’s possible for patients. As a key member of the Sail Biomedicines Data Science team, the Senior Scientist I will operate at the interface of platform and program, applying data-driven approaches to champion broad platform efforts and hands-on analysis of preclinical datasets to transform the treatment landscape for autoimmune diseases, and beyond.

The ideal candidate will combine strong biological insight with quantitative rigor, applying data-driven approaches to extract actionable understanding from complex preclinical and platform datasets while helping establish scalable computational foundations for future discovery efforts. In addition to supporting in vivo CAR immunology programs, this role will contribute to emerging capabilities in systems modeling, computational protein design, molecular modeling, and AI/ML-enabled therapeutic engineering.

Partnering closely with experimental scientists, you will spearhead efforts to translate platform and program data into actionable understanding of biology, enabling rapid iteration across our therapeutic learning cycle.

## Responsibilities

- Perform in-depth analysis of preclinical and platform datasets, including immunophenotyping, functional assays, and multi-omics data to support both therapeutic programs and platform development
- Integrate and interpret data across studies and contexts to generate biological insights that inform CAR activity, persistence, immune dynamics and platform-level understanding of our therapeutics
- Collaborate closely with immunology and platform teams to inform experimental design and interpret results
- Work resourcefully with internal/external datasets to contextualize findings and strengthen conclusions
- Apply statistical and systems modeling to develop deeper understanding of product and platform attributes and performance.
- Apply and promote best practices in data structuring, annotation, and metadata usage to enable reliable, scalable and reusable downstream analysis across programs and platform efforts
- Develop and maintain reproducible analysis workflows, with clear documentation and version control (Git) and contribute to a well-organized data environment by following FAIR-aligned practices in day-to-day work
- Communicate findings clearly with collaborators through visualizations, presentations, and written summaries

## Qualifications

Required:

- Ph.D. in Computational Biology, Bioinformatics, Systems Biology, Biophysics or related field
- 3+ years of experience analyzing multifaceted biological datasets in biotech, pharma, or academia
- Firsthand experience working in CAR-T or RNA therapeutics.
- Demonstrated experience applying modeling (statistical, system) to biological data.
- Strong expertise in high-dimensional data analysis (e.g., RNA-seq, single-cell, in vivo studies) with the ability to transform raw data to refined downstream biological interpretations
- Proficiency in Python and/or R, with strong data analysis and visualization skills and a firm grasp of modern statistics (mixed models, Bayesian methods, etc.)
- Experience building reproducible and well-documented analysis workflows (Nextflow, Snakemake) and applying sound data organization and metadata practices
- Demonstrated ability to champion cross-functional efforts in close collaboration with experimental scientists, taking ownership and driving insights even in areas outside your core subject matter expertise

Preferred:

- Computational design of Antibody/VHH/scFv/CAR proteins
- Experience in immunology, cell therapy, or CAR biology, particularly in vivo systems
- Experience integrating complex datasets and cross-study meta-analysis
- Exposure to cloud-based or collaborative data environments
- Track record of impactful scientific contributions (publications or program support)

## About Sail Biomedicines

Sail Biomedicines is building a new class of fully programmable medicines by integrating circular RNA (eRNA™), targeted nanoparticle delivery, and advanced computational approaches. Our platform enables the systematic design and optimization of therapies, unlocking new possibilities across immunology and beyond.

Salary Range: $130,000 - $170,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

## About Sail Biomedicines 

## Company Overview
- **One-liner**: Sail Biomedicines is pioneering a fully programmable RNA medicines platform by combining proprietary circular RNA technology (eRNA) with targeted nanoparticles and generative AI to treat autoimmune, metabolic, infectious, and rare diseases.
- **Entity Type**: Private (backed by Flagship Pioneering, formed in October 2023)
- **Headquarters**: Cambridge, Massachusetts, USA
- **Founded**: October 2023 (formed from the combination of first-in-category technologies within the Flagship Pioneering ecosystem, bringing together more than eight years of combined data)
- **Founders**: The company was formed by Flagship Pioneering; key leadership includes John Mendlein, J.D., Ph.D. (Executive Chairman), Gene Marcantonio, M.D., Ph.D. (Chief Medical Officer), Amy Espeseth (SVP, Platform), and others.

## Core Business
- **Primary industry**: Biotechnology / RNA Therapeutics / Drug Discovery
- **Target customers**: B2B / Biopharma partnerships; ultimate customers are patients with chronic and serious diseases (autoimmune, metabolic, infectious, rare)
- **Mission statement**: "We work at the frontier of programmable medicines. We power our bioplatform and product candidates by harnessing evolution and AI. We operate with purpose and urgency on behalf of people everywhere. We aim to generate life-changing impact for the world."

## Products & Services
- **Sail Platform (Endless RNA™ / eRNA™)**: A novel class of translatable, stable circular RNA. Unlike conventional linear mRNA, eRNA is protected from exonuclease degradation, leading to prolonged protein expression in vivo (days vs. 1-2 days for mRNA). This enables less frequent dosing and opens the door for treating chronic diseases requiring intracellular or transmembrane protein replacement.
- **Targeted Nanoparticles (TNPs)**: A modular, clinically validated lipid nanoparticle core conjugated with disease-specific targeting ligands. These TNPs enable precise, extra-hepatic delivery of eRNA cargo to specific cell types, minimizing off-target exposure. The same core can be rapidly adapted with different ligands.
- **Generative AI & Data Platform**: Proprietary AI algorithms integrated with high-throughput prototyping to design both the RNA sequence and the nanoparticle delivery system in an integrated manner, aiming to program medicines to spec.

## Market Standing
- **Valuation / Funding**: Not publicly disclosed. As a Flagship Pioneering portfolio company, it benefits from substantial, long-term venture funding typical of Flagship’s "venture creation" model. The company was formed in 2023, so it is in an early-stage, pre-revenue R&D phase.
- **Key Metric**: Total funding is not publicly available; the company is privately held and was formed through an internal combination of assets from Flagship’s ecosystem (including Laronde and Senda Biosciences).
- **Notable Investors/Partners**: Flagship Pioneering is the founding and primary backer. The company's leadership includes experienced executives from the Flagship network.
- **Growth Signals**: The company is actively hiring across multiple senior roles (Senior Director of Delivery, Director of Translational Biology, Associate Director of Clinical Supply Chain, Senior Scientist in Data Science), indicating a ramp-up from platform development toward preclinical and early clinical activities.

## Competitive Advantages
- **Most Complete Toolkit**: Sail claims to have the industry's only platform that integrates programmable pharmacology (eRNA) with programmable deployment (TNPs) and AI-driven design, all in one system.
- **Durable eRNA**: The circular RNA technology offers significantly longer protein expression than linear mRNA, a major differentiator for chronic disease applications.
- **Modular Nanoparticle Platform**: The TNP core is clinically validated and can be rapidly re-targeted by swapping ligands without reformulating the core, enabling faster path to IND for multiple indications.
- **AI-Powered Integration**: The company generates proprietary functional data at high throughput to train AI models that design both the RNA and the nanoparticle in an integrated manner, a capability few competitors have.
- **Flagship Ecosystem Backing**: Deep resources, long-term capital, and a history of building category-defining biotechs (Moderna, etc.) provide a strong foundation.

## Strategic Focus
- **Current priorities**: Advancing the eRNA-TNP platform toward the clinic; building out the AI/digital sciences team; expanding the pipeline in autoimmune, metabolic, infectious, and rare diseases; demonstrating in vivo proof-of-concept for extra-hepatic targeting with TNPs.
- **Direction for growth**: Moving from platform R&D to IND-enabling studies and first-in-human trials; establishing partnerships with larger pharma for specific indications; scaling the manufacturing process for eRNA and TNPs.

## Why Work Here
- **Culture**: "We work at the frontier of programmable medicines. We operate with purpose and urgency on behalf of people everywhere." The company emphasizes a culture of excellence, shared dedication, and groundbreaking science.
- **Remote/Hybrid Policy**: Roles are listed in Cambridge, MA, suggesting an on-site or hybrid model at the headquarters (140 First Street, Cambridge, MA 02141).
- **Notable Perks** (from careers page):
    - Generous salary and employee stock option plan
    - Competitive health, dental, and vision benefits
    - Retirement savings program
    - Paid parental, adoption, and caregiver leave
    - Long- and short-term disability and life insurance
    - Employee assistance program
    - Free parking, monthly subway pass, or subsidized commuter rail pass
    - Free lunch every week and a kitchen stocked with healthy snacks
- **Engineering/Science Culture**: The company is building a "bioplatform" that integrates AI, data science, and high-throughput experimentation. This is an ideal environment for scientists and engineers who want to work at the intersection of computational biology, machine learning, and RNA therapeutics. The team includes leaders in AI and digital sciences, pharmacology, and nanoparticle delivery.

## Sources
1. [sail.bio](https://www.sail.bio/)
2. [sail.bio - About Us](https://www.sail.bio/about-us/)
3. [sail.bio - Our Science](https://www.sail.bio/our-science/)
4. [sail.bio - Careers](https://www.sail.bio/careers/)
5. [Greenhouse Job Board](http://job-boards.greenhouse.io/sendabiosciences)

## Other roles at Sail Biomedicines 

- [Scientist I](https://feeny.ai/job/scientist-i-sail-biomedicines-cambridge-e9n5yhd2xeak) — Cambridge, MA
- [Research Associate II, Preclinical Manufacturing](https://feeny.ai/job/research-associate-ii-preclinical-manufacturing-sail-biomedicines-cambridge-49vd1degc0y1) — Cambridge, MA
- [Senior Research Associate, Platform RNA Sciences](https://feeny.ai/job/senior-research-associate-platform-rna-sciences-sail-biomedicines-cambridge-c0n3by59f31b) — Cambridge, MA
- [Senior Research Associate, High-Throughput RNA Production](https://feeny.ai/job/senior-research-associate-high-throughput-rna-production-sail-biomedicines-ytr4fcfv77pt) — Cambridge, MA
- [Scientist, Platform RNA Sciences](https://feeny.ai/job/scientist-platform-rna-sciences-sail-biomedicines-cambridge-x5e3e1ccssb8) — Cambridge, MA
- [Senior Research Associate](https://feeny.ai/job/senior-research-associate-sail-biomedicines-cambridge-11ngttpwsden) — Cambridge, MA
- [Associate Scientist, Formulation, Pilot Lab](https://feeny.ai/job/associate-scientist-formulation-pilot-lab-sail-biomedicines-cambridge-v21s80qjbt2a) — Cambridge, MA
- [Associate Project Manager / Project Manager](https://feeny.ai/job/associate-project-manager-project-manager-sail-biomedicines-cambridge-mwz44mhbz3pz) — Cambridge, MA