---
title: 'Senior Scientist Single Cell Assay and Technology Development at Xaira Therapeutics'
canonical: 'https://feeny.ai/job/senior-scientist-single-cell-assay-and-technology-development-xaira-04cnkksa179e'
type: 'job'
last_seen: '2026-10-26'
---

# Senior Scientist Single Cell Assay and Technology Development at Xaira Therapeutics

- **Company:** Xaira Therapeutics
- **Location:** South San Francisco, CA
- **Posted:** 2026-10-21
- **Last confirmed live:** 2026-10-26
- **Apply:** https://job-boards.greenhouse.io/xairatherapeutics/jobs/5271881007

## Job description

## About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

## About the Role

As a Senior Scientist on Xaira’s High-throughput Biology team, you will invent and develop single-cell assays for AI-driven drug discovery. You will create new molecular readouts and extend commercial and published technologies to measure cellular state and responses at scale. You will own development from concept and feasibility through reproducible workflows for high-throughput data generation.

Join a small, multidisciplinary technology development team where you will shape technical direction. Working with biologists, engineers, and computational scientists, you will rapidly design, prototype, and test new assays. You will help decide which ideas to pursue, which technologies to adopt, and how to expand their capabilities. The assays you build will generate data that power Xaira’s machine-learning models.

## Key Responsibilities

- Conceive, prototype, and develop novel single-cell assays, and expand commercial workflows to enable new molecular readouts and biological applications.
- Develop and troubleshoot assay components from sample preparation and barcoding through reverse transcription, amplification, targeted or whole-transcriptome NGS library preparation, and QC; design custom primers, oligonucleotides, and barcodes.
- Build mammalian cell systems and functional assays using cell engineering, flow cytometry, imaging, and in situ hybridization.
- Partner with biology and engineering teams to turn prototypes into reproducible, scalable workflows and document protocols for transfer to internal teams.
- Evaluate emerging technologies.

## Qualifications

- PhD in molecular biology, cell biology, bioengineering, biochemistry, immunology, or a related field, with 4+ years of relevant experience, including industry experience in assay or technology development.
- Candidates with fewer than 4 years of postdoctoral experience, with strong single-cell assay/technology development experience, are encouraged to apply. The title can be adjusted accordingly.
- A track record of inventing or substantially improving single-cell, NGS, or cell-based assays.
- Curiosity and the ability to learn unfamiliar techniques quickly and apply them to new assay concepts.
- Expertise in molecular biology and NGS assay development, including nucleic acid handling, reverse transcription, enzymatic reactions, oligonucleotide design, and library preparation and QC.
- Experience developing or adapting single-cell sequencing workflows, with strong troubleshooting and problem-solving skills across biology, assay chemistry, instrumentation, and data.
- Strong mammalian cell biology skills, including cell culture and functional assay development.
- Strong analytical skills in experimental design and statistical analysis of NGS and single-cell data; proficiency in R or Python.
- Strong organizational skills and clear written and oral communication.
- Ability to work effectively in a fast-paced, rapidly changing environment.

## Preferred Qualifications

- Antibody engineering, expression, QC, conjugation, or functional testing; immunology or primary immune cell assays.
- High-throughput or miniaturized assays, lab automation, or design of experiments.
- Pooled screening, genetic or chemical perturbation assays, or molecular reporter development with sequencing-based readouts.

## Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $136,000 - $170,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics is an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.

## About Xaira Therapeutics

## Company Overview
- **One-liner**: Xaira Therapeutics is an integrated biotechnology company applying artificial intelligence across the entire drug discovery and development process to design next-generation medicines.
- **Entity Type**: Private (Series A)
- **Headquarters**: South San Francisco, California, United States (with offices in Seattle, Washington, and London, UK)
- **Founded**: 2023
- **Founders**: Co-founded and incubated by ARCH Venture Partners and Foresite Labs, with foundational scientific contributions from Nobel Laureate Dr. David Baker (Institute for Protein Design, University of Washington).

## Core Business
- **Primary industry/industries**: Biotechnology, Drug Discovery & Development, Artificial Intelligence
- **Target customers**: B2B (pharmaceutical partners, biotech collaborators) and ultimately patients via its own therapeutic pipeline.
- **Mission or purpose statement**: "Pioneering the transformative artificial intelligence that will help discover and develop the next generation of life-changing medicines." [xaira.com](https://www.xaira.com/)

## Products & Services
- **AI-Powered Drug Discovery Platform**: An end-to-end platform integrating advanced AI research, expansive data generation (functional genomics, proteomics, multi-omics), and robust therapeutic product development to shift drug discovery from an empirical science to a precise engineering discipline. [xaira.com](https://www.xaira.com/our-approach)
- **Computational Protein Design**: Built on foundational work by Nobel Laureate Dr. David Baker, leveraging AI to design entirely new proteins from scratch for previously undruggable targets. [xaira.com](https://www.xaira.com/our-approach)
- **X-Cell (Virtual Cell Model)**: An AI model trained on billions of genomic data points to simulate and understand cellular biology. [xaira.com](https://www.xaira.com/)
- **Therapeutic Pipeline**: A pipeline of differentiated therapeutics across multiple modalities (small molecules, biologics, protein therapeutics) developed through an integrated AI-driven process.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed. The company launched in 2023 with a $1 billion Series A financing, one of the largest in biotech history.
- **Key Metric**: Total Funding of $1 billion (Series A, 2023).
- **Notable Investors/Partners**: ARCH Venture Partners (co-founder and lead investor), Foresite Labs (co-founder and incubator), F-Prime Capital, and other top-tier investors. Board includes leaders from ARCH, Foresite, NEA, and Johnson & Johnson. Scientific advisors include Nobel Laureates Carolyn R. Bertozzi and David Baker, and other luminaries. [xaira.com](https://www.xaira.com/our-team)
- **Growth Signals**: Launched in 2023 with a record $1B Series A; rapidly building a world-class team across three global hubs (South San Francisco, Seattle, London); actively hiring across AI, computational biology, protein design, and drug development roles; announced X-Cell, a virtual cell model trained on billions of genomic data points. [xaira.com](https://www.xaira.com/)

## Competitive Advantages
- **Unprecedented Capital & Talent**: Launched with a $1B Series A, enabling aggressive hiring of top-tier AI and biology talent and long-term investment in infrastructure.
- **End-to-End AI Integration**: Uniquely positioned to apply AI across the entire drug discovery and development lifecycle, from target identification to clinical development, creating a powerful data flywheel.
- **World-Class Scientific Foundation**: Built on foundational AI protein design work from Nobel Laureate David Baker's lab, with a board and advisory board including multiple Nobel Laureates, former FDA commissioners, and industry leaders from Genentech, Johnson & Johnson, and top venture firms. [xaira.com](https://www.xaira.com/our-team)
- **Massive Data Generation**: Investing heavily in functional genomics and proteomics to generate proprietary, multi-dimensional datasets that fuel AI model development, creating a defensible data moat.

## Strategic Focus
- **End-to-End AI Integration**: Building predictive and agentic AI models across the complete drug discovery and development spectrum to increase probability of success, reduce timelines, and lower costs. [xaira.com](https://www.xaira.com/our-approach)
- **Data as a Core Asset**: Generating and integrating massive, multi-dimensional biological datasets (from molecular to human scales) to train and improve AI models continuously.
- **Pipeline Development**: Advancing a pipeline of differentiated therapeutics across multiple modalities (small molecules, biologics, protein therapeutics).
- **Talent Acquisition**: Aggressively hiring across AI research, engineering, computational biology, protein design, and drug development to build a world-class, interdisciplinary team.

## Why Work Here
- **Mission-Driven**: Opportunity to work at the forefront of AI and biology to fundamentally transform how medicines are discovered and developed, with the potential to impact millions of patients.
- **World-Class Team & Mentorship**: Work alongside and learn from Nobel Laureates, top AI researchers, and experienced drug developers from leading pharma and biotech companies. [xaira.com](https://www.xaira.com/our-team)
- **Interdisciplinary Culture**: A unique blend of AI/ML engineers, protein designers, computational biologists, and drug hunters all working together in a highly collaborative environment.
- **Global Hubs & Flexibility**: Offices in South San Francisco, Seattle, and London, offering multiple locations for talent.
- **Generous Resources**: Backed by a $1B Series A, providing the resources to pursue ambitious, long-term research without short-term funding pressure.
- **Job Scam Awareness**: The company has issued a warning about fraudulent job offers; all legitimate recruitment is conducted through official channels (Greenhouse) and never via Google Chat or requests for payment. [xaira.com](https://www.xaira.com/work-with-us)

## Sources
1. [xaira.com](https://www.xaira.com/)
2. [xaira.com](https://www.xaira.com/our-approach)
3. [xaira.com](https://www.xaira.com/our-team)
4. [xaira.com](https://www.xaira.com/work-with-us)
5. [greenhouse.io](https://job-boards.greenhouse.io/xairatherapeutics)

## Other roles at Xaira Therapeutics

- [Senior Associate Scientist, High Throughput Protein Production](https://feeny.ai/job/senior-associate-scientist-high-throughput-protein-production-xaira-swgcd9st1mvn) — South San Francisco, CA
- [Robotics Systems & Simulation Engineer](https://feeny.ai/job/robotics-systems-simulation-engineer-xaira-therapeutics-south-san-francisco-fv7m7yvh7rkd) — South San Francisco, CA
- [Principal Scientist, Target Discovery & Portfolio Strategy](https://feeny.ai/job/principal-scientist-target-discovery-portfolio-strategy-xaira-therapeutics-e1120npv099c) — South San Francisco, CA
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