---
title: 'Senior Scientist, Translational Science at Spyre Therapeutics'
canonical: 'https://feeny.ai/job/senior-scientist-translational-science-spyre-therapeutics-united-states-2bxjq71x123q'
type: 'job'
last_seen: '2026-10-27'
---

# Senior Scientist, Translational Science at Spyre Therapeutics

- **Company:** Spyre Therapeutics
- **Location:** United States
- **Work type:** remote
- **Posted:** 2026-10-01
- **Last confirmed live:** 2026-10-27
- **Apply:** https://job-boards.greenhouse.io/spyretherapeutics/jobs/5439907008

## Job description

Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, IL-23, and IL-17A/F as well as rational combination programs.

## Role Summary

We are seeking a highly skilled and motivated Senior Scientist, Translational Science, to join our growing team. This individual will support the execution of outsourced bioanalytical and biomarker activities for Spyre's clinical programs, with primary responsibility for pharmacokinetic, immunogenicity, and PD assays. This role will contribute to assay development, qualification, validation, sample analysis, data interpretation, and reporting across multiple analytical platforms at Contract Research Organizations (CROs). The Senior Scientist will serve as a scientific point of contact for CROs, communicate plans and progress within the translation sciences team, and help ensure that all activities are conducted in accordance with applicable regulatory requirements, company procedures, and program timelines.

## Key Responsibilities

- Manage the day-to-day execution of outsourced bioanalytical activities for pharmacokinetic, immunogenicity, and/or biomarker assays conducted at CROs.
- Provide scientific input to the design, development, qualification, validation, implementation, and maintenance of bioanalytical methods in accordance with applicable regulatory guidance and industry practices.
- Review assay protocols, validation plans and reports, sample analysis plans and reports, and bioanalytical data packages for scientific quality, completeness, and data integrity.
- Coordinate with CROs and internal partners to track milestones, communicate risks, and support timely availability of required scopes, quotes, contracts, purchase orders, samples, and reagents.
- Plan and coordinate clinical sample analysis across multiple studies, including sample availability, testing priorities, laboratory timelines, and data delivery.
- Work with internal and external subject matter experts to investigate and resolve issues that arise during assay development, validation, or clinical sample analysis.
- Evaluate bioanalytical data, trends, and anomalies; summarize conclusions and communicate results clearly within the translation science team.
- Contribute bioanalytical content to laboratory manuals and data transfer agreements.
- Other duties as assigned.

Ideal Candidate

- PhD in biology, biochemistry, pharmacology, chemistry, or a related scientific discipline with 2+ years of relevant industry experience; or MS with 5+ years of relevant experience in regulated bioanalysis and drug development in the biotechnology or pharmaceutical industry..
- Experience supporting large-molecule pharmacokinetic and immunogenicity assays, including neutralizing antibody methods.
- Working knowledge of multiple bioanalytical platforms, such as LC-MS/MS, ELISA, electrochemiluminescence, ligand-binding assays, MSD, and/or multiplex assays.
- Experience engaging and overseeing CROs, including review of technical documents, data, reports, and study deliverables.
- Knowledge of GLP, GCLP, data integrity principles, and applicable bioanalytical and immunogenicity regulatory expectations.
- Experience writing or reviewing bioanalytical reports and contributing scientific content to regulatory submissions.
- Excellent written and verbal communication skills, sound scientific judgment, and the ability to explain technical information to varied audiences.
- Detail-oriented and collaborative, with strong organizational, prioritization, and time-management skills and the ability to manage multiple activities in a fast-moving environment.

## What We Offer

- Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture of our young company, wear multiple hats, and learn quickly.
- Market-competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
- Unlimited PTO
- Two, one-week company-wide shutdowns each year.
- Commitment to growing you professionally and providing access to resources to further your development.
- 100% remote team with frequent in-person meetings to build relationships and problem solve.

The expected salary range offer for this role is $144,000to $170,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location. As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.

Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.

Please also be aware that all job postings will be listed on our website at spyre.com/careers/.

## About Spyre Therapeutics

## Company Overview
- **One-liner**: Spyre Therapeutics is a clinical-stage biotechnology company developing next-generation antibody therapies and rational combinations to elevate the standard of care for inflammatory bowel disease (IBD) and other immune-mediated diseases.
- **Entity Type**: Public (NASDAQ: SYRE [ir.spyre.com](https://ir.spyre.com/overview))
- **Headquarters**: Not publicly available (company operates 100% remote with frequent in-person meetings [job-boards.greenhouse.io](https://job-boards.greenhouse.io/spyretherapeutics))
- **Founded**: Not publicly available
- **Founders**: Not publicly available

## Core Business
- **Primary industry/industries**: Biotechnology / Biopharmaceuticals / Immunology
- **Target customers**: B2B (partners, healthcare providers, payers); primarily focused on patients with IBD (Crohn’s disease, ulcerative colitis) and other immune-mediated conditions
- **Mission or purpose statement**: “Develop potentially best-in-class therapeutics for people living with IBD” by combining best-in-class antibody engineering, dose optimization, and rational therapeutic combinations [spyre.com](https://www.spyre.com/)

## Products & Services
Spyre’s pipeline consists of investigational extended half-life antibodies targeting validated mechanisms, designed for subcutaneous administration and potentially improved efficacy and convenience:
- **SPY001 (α4β7 integrin inhibitor)**: Phase 3-ready anti-integrin antibody with extended half-life; targeting gut-selective inflammation control [spyre.com](https://www.spyre.com/pipeline)
- **SPY120 (TL1A antibody)**: Phase 1/2 anti-TL1A antibody targeting fibrostenotic and inflammatory pathways in IBD [spyre.com](https://www.spyre.com/pipeline)
- **SPY130 (IL-23 antibody)**: Phase 1/2 anti-IL-23 p19 antibody targeting a validated and highly successful mechanism in IBD [spyre.com](https://www.spyre.com/pipeline)
- **SPY002 (α4β7 + TL1A) and SPY003 (α4β7 + IL-23)**: Rational combination programs designed to deliver more complete disease control and greater durability than monotherapy

## Market Standing
- **Valuation/Market Cap**: Not explicitly stated; recent public offering raised substantial capital
- **Key Metric**: **Total Funding via Public Offering**: $463.5 million gross proceeds from a public offering and full exercise of underwriters’ option, announced May 1, 2026 (upsized from $403.0M) [ir.spyre.com](https://ir.spyre.com/overview)
- **Notable Investors/Partners**: The company is publicly traded; institutional and retail investors participated in the offering. Partnership and investor details are disclosed in SEC filings.
- **Growth Signals**:
  - Announced positive **SPY001 Part A Induction Results** on April 14, 2026, demonstrating proof-of-mechanism [ir.spyre.com](https://ir.spyre.com/overview)
  - Raised $463.5M in a single public offering in May 2026, signaling strong institutional confidence
  - Pipeline advancing into Phase 2 and Phase 3 programs across multiple antibody formats
  - Company is rapidly expanding its R&D and clinical capabilities

## Competitive Advantages
- **Rational Combination Strategy**: Spyre is one of the few companies pioneering concurrent targeting of α4β7 with TL1A or IL-23 in a single therapeutic program, potentially offering superior efficacy over single-target biologics
- **Extended Half-Life Antibody Engineering**: All pipeline antibodies are engineered for longer dosing intervals, which could improve patient adherence and convenience
- **100% Remote-First Model**: Operates a fully remote team with periodic in-person gatherings, allowing access to top talent across geographies without requiring relocation
- **Deeply Validated Biology**: All three primary targets (α4β7, TL1A, IL-23) are clinically validated in IBD, derisking the pipeline

## Strategic Focus
- Advance **SPY001** into Phase 3 trials for IBD
- Progress **SPY120** and **SPY130** through Phase 1/2 dose optimization and proof-of-concept studies
- Generate clinical data for the **rational combination programs (SPY002, SPY003)** to demonstrate additive/synergistic benefit
- Leverage the significant capital raise to expand clinical operations, manufacturing, and pipeline expansion

## Why Work Here
- **100% Remote-First Culture**: Spyre is fully remote with “frequent all team, in-person meetings to build relationships and problem solve” [job-boards.greenhouse.io](https://job-boards.greenhouse.io/spyretherapeutics)
- **Generous Time Off**: Unlimited PTO plus two one-week company-wide shutdowns each year
- **Competitive Compensation**: Market-competitive base salary, performance bonus, and equity grant opportunities
- **Comprehensive Benefits**: Health, welfare, and retirement benefits included
- **Fast-Paced Startup Environment**: Opportunities to “wear multiple hats, learn quickly, and help shape the culture of our young company”
- **Mission-Driven**: Direct impact on improving the lives of millions of IBD patients. The team is described as “collaborative and interdisciplinary” [spyre.com](https://www.spyre.com/careers)
- **Transparent and Accessible Leadership**: Company updates and financial results are shared regularly; recent events include public webcasts and presentations

## Sources
1. [spyre.com](https://www.spyre.com/)
2. [ir.spyre.com](https://ir.spyre.com/overview)
3. [job-boards.greenhouse.io](https://job-boards.greenhouse.io/spyretherapeutics)
4. [spyre.com/careers](https://www.spyre.com/careers)
5. [spyre.com/pipeline](https://www.spyre.com/pipeline)

## Other roles at Spyre Therapeutics

- [Executive Director, Clinical Operations](https://feeny.ai/job/executive-director-clinical-operations-spyre-therapeutics-united-states-p8kh871y1tyz) — United States
- [Senior Director, Biostatistics](https://feeny.ai/job/senior-director-biostatistics-spyre-therapeutics-united-states-t018pkc6s859) — United States
- [Director, Drug Safety Physician](https://feeny.ai/job/director-drug-safety-physician-spyre-therapeutics-united-states-34byjx96nsbr) — United States
- [Senior Director, Drug Safety and Pharmacovigilance Operations](https://feeny.ai/job/senior-director-drug-safety-and-pharmacovigilance-operations-spyre-therapeutics-8z5gh0007fj3) — United States
- [Associate Director, Clinical Supply Chain](https://feeny.ai/job/associate-director-clinical-supply-chain-spyre-therapeutics-united-states-bat1jhy7310w) — United States