---
title: 'Senior Software Engineer at Probably Genetic'
canonical: 'https://feeny.ai/job/senior-software-engineer-probably-genetic-san-francisco-cs031fj0pe4d'
type: 'job'
last_seen: '2026-09-10'
---

# Senior Software Engineer at Probably Genetic

- **Company:** Probably Genetic
- **Location:** San Francisco, CA
- **Compensation:** $150k–$210k
- **Employment:** full-time
- **Work type:** hybrid
- **Posted:** 2026-05-13
- **Last confirmed live:** 2026-09-10
- **Apply:** https://jobs.ashbyhq.com/probablygenetic/8f428ab0-80e7-4b3d-bc91-b347e407204d

## Job description

## About Probably Genetic

Probably Genetic is changing the lives of patients living with severe, complex diseases. Our data platform is used by drug developers and patient advocacy groups to develop and launch treatments for these patients. Our technology discovers undiagnosed patients online, analyzes their disease state using machine learning and at-home testing, and enables compliant communication with patients. In doing so, we help patients access diagnoses, clinical trials, and treatments as early as possible. We are a tight-knit group of hard-working, ambitious problem solvers united by a mission greater than ourselves. We do well by doing right by patients. We are developing some of the most cutting-edge solutions in healthcare, and our roadmap is packed with innovations in bioinformatics, AI, and drug development. We have built a lean, all-star team to help us bring our vision to life, and we want you to be a part of it. Probably Genetic has raised multiple rounds of funding from Silicon Valley’s best investors, including Threshold, Khosla, and Y Combinator, and offer competitive salaries, comprehensive benefits, and meaningful early stage equity.

## About the Role

We are looking for a Senior Software Engineer who will contribute to the design and implementation of our AI-enabled patient experience, genetic sequencing workflows, and help enable the critical infrastructure needed to support a world-class patient intelligence platform. Come build with us and make a real difference in the lives of our patients!

## What you will do

- Work across teams to rapidly transform key requirements into front-end releases that meaningfully improve how patients engage with our product
- Create APIs, laboratory integrations, bioinformatic tooling, and ML infrastructure using Python, Django, PostgreSQL databases, and AWS services
- Develop the phenotyping product and biotech data platform frontends in React & Typescript
- Regularly review your team’s pull requests and technical proposal documents to maintain high standards and architectural quality
- Present your work to relevant stakeholders, monitoring outcomes, and integrating patient feedback
- Contribute to a culture of continuous improvement at a high velocity by optimizing development processes
- Own business goals and writing technical design specifications to find more patients, grow revenue, and increase margins
- Collaborate with Product and other business teams to implement solutions which drive customer value
- Work with cross-functional stakeholders to refine business processes and develop software to automate those processes

## Who you are

We are looking for a few specific things that will help you succeed in this role:

- Proven experience developing full-stack applications, with a front-end focus and a passion for shipping high quality code at velocity
- Experience in a range of software languages and frameworks included in our tech stack:
- Languages: Python (Django) and Typescript (React)
- Tools/Infrastructure: PostgreSQL, AWS, Terraform, GitHub Actions
- Experience designing and building scalable systems used by external users
- Track-record of solving extremely difficult, ambiguous problems
- Excellent communication skills with ability to can convey your ideals clearly to engineers and non-engineers alike!

Some things that are not required, but you will learn on the job:

- Expertise with healthcare data, bioinformatics, genetics, ML infrastructure, or growth marketing
- Expertise in HIPAA compliance and security best practices
- Expertise in product development practices such as user interviews and product analytics

As with all new hires at Probably Genetic, you will also need to be:

- A good person. We work with some of the most marginalized populations on the planet and empathy is key.
- Patient-focused and motivated to have a lasting, positive impact on humanity.
- Comfortable in a fast-paced, often ambiguous environment with rapid change.
- Action-oriented and excited to build a company from the ground up.

The salary range for this role is $150,000-$210,000 annually. Actual compensation offered will depend on several factors including but not limited to: work experience, education, skill level, and/or other business and organizational needs.

This is a hybrid role that will requires working on-site 3 days a week (Tuesday, Wednesday, Thursday) in San Francisco and we are open to relocation. What we offer at Probably Genetic:

- An engaging and supportive team all on a mission to improve lives
- Fair and equitable compensation with competitive early-stage equity grants
- Generous Flexible Time off policy, that we actually use
- Parental Leave Benefits (12 weeks for both birthing and non-birthing)
- Hybrid, flexible work with high-trust and autonomy
- A bright, inviting, pet-friendly office in Downtown SF near transit
- Company-sponsored team lunch every Thursday
- A “work from anywhere” policy, up to 4 weeks a year
- Regular team retreats in exciting destinations
- Health Benefits including medical, dental, vision, therapy, FSA, and 401k
- And so much more!

Probably Genetic is committed to fostering a welcoming and inclusive work environment for people of all genders, sexuality, ethnicity, socioeconomic background and life experiences. We urge candidates of all backgrounds to apply. If you require specific accommodations as you interview or consider working with us, please let us know.

## About Probably Genetic

## Company Overview
- **One-liner**: Probably Genetic uses AI and at-home genetic testing to help diagnose rare genetic diseases and connect patients to treatments, while powering drug development with real-world data.
- **Entity Type**: Private (Seed-stage; Y Combinator Winter 2019 batch)
- **Headquarters**: San Francisco, California, United States
- **Founded**: 2019 (per Y Combinator; company website states 2018 – conflicting reports)
- **Founders**: Lukas Lange (CEO & Co-Founder)

## Core Business
- **Primary industry**: Healthcare / Genetic Testing / Biotechnology
- **Target customers**: B2B (drug developers, patient advocacy groups, clinical labs) and B2C (patients with undiagnosed rare diseases and their caregivers)
- **Mission**: "We develop AI to diagnose 200+ million patients living with genetic disease to help them access the treatments they need and catalyze drug development."

## Products & Services
- **Probably Genetic Platform (Patient Intelligence Platform)**: End-to-end system that identifies undiagnosed patients via an AI-powered symptom checker, ships at-home saliva or cheek swab kits, provides genetic counseling, and delivers clinical-grade reports. The platform is used by drug developers to discover and engage eligible patients for clinical trials and sponsored testing programs. (SaaS + Services)
- **Free Sponsored Testing Programs**: Offered in partnership with pharmaceutical companies and patient advocacy groups, allowing eligible patients to access genetic testing at no cost.

## Market Standing
- **Valuation**: Not publicly available
- **Key Metric**: Total Funding – USD 11.2 million (as of latest LinkedIn data) across multiple rounds (Pre-Seed led by Y Combinator, Seed, and Angel Round in 2022)
- **Notable Investors/Partners**: Y Combinator, Threshold, Khosla Ventures; partnered with 50+ patient advocacy groups (e.g., NORD, Global Genes)
- **Growth Signals**:
  - 200,000+ patients have used the platform
  - >6x year-over-year revenue growth (self-reported)
  - Profitable (stated on Y Combinator jobs page)
  - Team size: 17 (Y Combinator) vs. 12 (LinkedIn, showing -21.4% YoY headcount decline – conflicting reports)
  - Global reach: services offered internationally

## Competitive Advantages
- Proprietary AI models trained on a large, growing dataset of rare disease phenotypes and genotypes
- Direct-to-consumer at-home testing removes barriers for undiagnosed patients
- CLIA-Certified & CAP-accredited lab; HIPAA-compliant data handling
- Strong integration with drug developer workflows (patient identification, consent, data sharing)

## Strategic Focus
- Expand the dataset and refine AI algorithms to improve diagnostic accuracy for more rare diseases
- Deepen partnerships with pharmaceutical companies to launch new sponsored testing programs
- Scale patient outreach globally, especially in underserved regions
- Advance bioinformatics and machine learning capabilities to accelerate drug development

## Why Work Here
- Mission-driven culture: "We do well by doing right by patients"
- Tight-knit, ambitious team united by a challenging problem
- Remote/hybrid policy: San Francisco headquarters with remote options within the US
- Competitive salaries ($150K–$190K for senior engineering roles) plus meaningful equity
- Notable perks: "Incredible team retreats to places like Barbados, the Alps, Mexico, Costa Rica, and Portugal"
- Y Combinator backing with a profitable, high-growth trajectory

## Sources
1. [probablygenetic.com](https://www.probablygenetic.com/)
2. [probablygenetic.com/about](https://www.probablygenetic.com/about-probably-genetic)
3. [ycombinator.com](https://www.ycombinator.com/companies/probably-genetic)
4. [ycombinator.com/jobs](https://www.ycombinator.com/companies/probably-genetic/jobs)
5. [linkedin.com](https://www.linkedin.com/company/probablygenetic)

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