--- title: 'Senior/Staff Full-Stack Engineer at Tahoe Therapeutics' canonical: 'https://feeny.ai/job/senior-staff-full-stack-engineer-tahoe-therapeutics-south-san-francisco-v1k7y7x878ef' type: 'job' last_seen: '2026-09-12' --- # Senior/Staff Full-Stack Engineer at Tahoe Therapeutics - **Company:** Tahoe Therapeutics - **Location:** South San Francisco, CA - **Compensation:** $150k–$250k - **Work type:** onsite - **Posted:** 2026-08-03 - **Last confirmed live:** 2026-09-12 - **Apply:** https://jobs.lever.co/tahoebio-ai/f52aa883-f297-4c53-be13-5a6c2a6af761 ## Job description ## About Tahoe Therapeutics Tahoe Therapeutics is a biotechnology company pioneering a fundamentally new approach to drug discovery, one that begins with the biology of real patients. Our Mosaic platform is the first to make in vivo data generation scalable, with single-cell resolution, allowing us to map how drugs affect patient-derived cells in the body across a wide range of biological contexts. We are building the world’s largest in vivo single-cell perturbation atlas and using it to train multimodal foundation models that learn the context-dependent nature of gene function, disease progression, and drug response. By combining cutting-edge Machine Learning with the most biologically relevant datasets ever assembled in drug discovery, our mission is to find better drugs, faster and bring them to more patients who need them. ## Your role Tahoe is building AI-native tools that change how drug discovery gets done. Our flagship agentic product, Tara, is becoming the connective tissue across our platform: the way scientists, engineers, and models interact with our data, our models, and each other. Tara has to feel effortless while doing hard things underneath, including real-time reasoning, secure integrations, streaming interfaces, and multi-agent orchestration. As a Senior/Staff Full-Stack Engineer, you will own product surface end-to-end and partner with our engineers, computational scientists, and ML team to make Tara robust, delightful, and secure. This role is well-suited for someone who has shipped real products at small teams, cares about the last mile (reliability, security, taste), and gets energy from working on AI-native problems where the right pattern is still being invented. We are looking for non-incremental thinkers who bring strong judgment on when to move fast, when to slow down, and when to reach for the right tool rather than build from scratch. ## Qualifications - Required Deep experience as a full-stack or product engineer at a startup or fast-moving team. Track record of owning ambitious products end-to-end (frontend, backend, database, deployment) from concept to production. Comfortable across a modern web stack and thoughtful about when to reach for which tool. Proven track record of building reliable and secure applications at scale. Strong communication and collaboration skills in a small team where boundaries between roles are fluid. ## Qualifications - Desirable Experience integrating LLMs or agents into production systems: streaming responses, tool orchestration, multi-agent coordination, or long-running autonomous workflows. Experience with observability and tracing for LLM or agentic systems (structured traces, cost attribution, replay, debugging when something goes wrong three tool calls deep). The mindset of an early engineer at an AI-native or fast-moving startup: high ownership, comfort with ambiguity, and bias toward action balanced with judgment. Interest in drug discovery, biology, or scientific tools. No formal background required, passion and curiosity are enough. ## Key Responsibilities Build Tara's end-to-end product surface: frontend, backend, real-time infrastructure, secure integrations. Partner with engineers and scientists to translate research capabilities into product experiences our users love. Tara is just the start. Build the next wave of AI-native tools and integrations that accelerate drug discovery at Tahoe. Set the bar for full-stack craft on the team: how we approach reliability, real-time UX, product velocity, and debugging. ## Benefits Unlimited Paid Time Off (PTO). Monthly Lunch budget One-time Office set up budget US Employees: HMO Kaiser Platinum and PPO Anthem Gold medical as well as vision and dental plans for both the employee and dependents. Canadian Employees: Manulife Silver plan This position requires on-site presence at our South San Francisco office a minimum of three days per week. We welcome applications from candidates in both Toronto, ON or San Francisco, CA, regions or those willing to relocate to the Bay Area or the Greater Toronto Area. Please note, we have one role open to two geographical locations. ## About Tahoe Therapeutics ## Company Overview - **One-liner**: Tahoe Therapeutics builds the ground truth for biological superintelligence by generating large-scale perturbative single-cell data and training AI models to predict cellular responses, transforming drug discovery. - **Entity Type**: Private (Series A) - **Headquarters**: South San Francisco, California, USA - **Founded**: 2022 (formerly Vevo Therapeutics) - **Founders**: Nima Alidoust (CEO & Cofounder), Johnny Yu (CSO & Cofounder), Hani Goodarzi (Cofounder) ## Core Business - **Primary industry**: Biotechnology / AI-powered drug discovery - **Target customers**: Biopharmaceutical companies, research institutions, and drug discovery partners - **Mission/purpose**: To build the ground truth for biological superintelligence — generating in vivo data at scale and training AI models to discover better drugs for more patients, including targets previously considered "undruggable." ## Products & Services - **Mosaic Platform**: Proprietary in vivo drug discovery platform that generates perturbative single-cell data at scale and single-cell precision across primary cells, organoids, iPSC-derived cells, and in vivo models with immune context. - **Rhaister**: A machine learning model for drug response prediction that learns from Tahoe's generated data and creates synthetic data for new biological contexts — trained in seconds, running in milliseconds. - **Tara**: An autonomous research agent that traverses Tahoe's data ocean, generates hypotheses, validates them, and surfaces discoveries rather than guesses. - **Tahoe-100M**: The world's largest open-source single-cell dataset, released as the inaugural contribution to Arc Institute's Virtual Cell Atlas. ## Market Standing - **Valuation/Market Cap**: Not disclosed (private company) - **Key Metric**: Total funding of $72M across three rounds (Seed $12M in 2022; two Series A rounds of $30M each in 2025) - **Notable Investors/Partners**: Wing Venture Capital, General Catalyst, Amplify Partners; partners include Parse Biosciences GigaLab, Arc Institute, and Alloy Therapeutics (joint venture for antibody-drug conjugates) - **Growth Signals**: Headcount grew ~40% YoY to ~29 employees; active job postings up 400% YoY; published the GENEVA platform in Nature Cancer (2026); released Rhaister (2026); formed ADC joint venture with Alloy Therapeutics (2026); open-sourced Tahoe-100M dataset (2025) ## Competitive Advantages - **Proprietary data flywheel**: Mosaic generates in vivo single-cell perturbation data at a scale and diversity competitors cannot easily replicate, feeding AI models that improve with each dataset. - **Open-source leadership**: Tahoe-100M is the largest open single-cell dataset, establishing the company as a standard-setter in the virtual cell atlas space. - **World-class team**: Founders and leadership have discovered drugs for undruggable targets, trained frontier AI models on chemical/biological data, and invented novel methods in single-cell and cancer biology. - **Integrated verification loop**: Tara closes the loop between hypothesis generation and validation, reducing reliance on guesses and accelerating discovery. ## Strategic Focus - Scaling the world's largest in vivo atlas of how drugs interact with patient cells. - Advancing AI models (Rhaister and successors) for drug response prediction and synthetic data generation. - Expanding therapeutic partnerships, including the Alloy Therapeutics joint venture for first-in-class antibody-drug conjugates. - Growing the team across machine learning, research, and drug discovery to support platform development and pipeline advancement. ## Why Work Here - **Culture**: "We are not content with incrementalism. We make big bets and work hard to make sure they happen." Team is dynamic, mission-driven, and focused on high-impact science. - **Work model**: Roles are primarily on-site in South San Francisco, with some hybrid opportunities (e.g., drug discovery roles). Current openings include Senior/Staff Full-Stack Engineer, Senior Machine Learning Engineer, Senior Machine Learning Scientist, and Research Associate. - **Perks & environment**: Inaugural hackathon for building on Tahoe-100M; exposure to cutting-edge AI + biotech; collaboration with top academic and industry partners; strong growth trajectory with a 40% headcount increase and expanding job postings. - **Caveat**: Employer rating is 2.3/5 based on 9 reviews (culture 2.0, career 2.1, compensation 2.9, work-life 3.5) — a small sample that may not reflect the current evolving environment. ## Sources 1. [tahoebio.ai](https://www.tahoebio.ai/) 2. [tahoebio.ai/about](https://www.tahoebio.ai/about) 3. [jobs.lever.co](https://jobs.lever.co/tahoebio-ai) 4. [linkedin.com](https://linkedin.com/company/tahoe-therapeutics) 5. [cbinsights.com](https://www.cbinsights.com/company/vevo-therapeutics) ## Other roles at Tahoe Therapeutics - [Senior Machine Learning Engineer](https://feeny.ai/job/senior-machine-learning-engineer-tahoe-therapeutics-south-san-francisco-hfzgjty255pq) — South San Francisco, CA - [Senior Machine Learning Scientist](https://feeny.ai/job/senior-machine-learning-scientist-tahoe-therapeutics-south-san-francisco-31vx0qt1qs41) — South San Francisco, CA - [Join us to build the future of drug discovery](https://feeny.ai/job/join-us-to-build-the-future-of-drug-discovery-tahoe-therapeutics-south-san-18wmeedyqxjz) — South San Francisco, CA