---
title: 'Senior Systems Engineer at Heartflow'
canonical: 'https://feeny.ai/job/senior-systems-engineer-heartflow-san-francisco-32qgs31sfet8'
type: 'job'
last_seen: '2026-10-19'
---

# Senior Systems Engineer at Heartflow

- **Company:** Heartflow
- **Location:** San Francisco, CA
- **Posted:** 2026-10-09
- **Last confirmed live:** 2026-10-19
- **Apply:** https://job-boards.greenhouse.io/heartflowinc/jobs/6218996004

## Job description

Heartflow is a medical technology company advancing the diagnosis and management of coronary artery disease, the #1 cause of death worldwide, using cutting-edge technology. The flagship product—an AI-driven, non-invasive cardiac test supported by the ACC/AHA Chest Pain Guidelines called the Heartflow FFRCT Analysis—provides a color-coded, 3D model of a patient’s coronary arteries indicating the impact blockages have on blood flow to the heart. Heartflow is the first AI-driven non-invasive integrated heart care solution across the CCTA pathway that helps clinicians identify stenoses in the coronary arteries (RoadMap™Analysis), assess coronary blood flow (FFRCT Analysis), and characterize and quantify coronary atherosclerosis (Plaque Analysis). Our pipeline of products is growing and so is our team; join us in helping to revolutionize precision heartcare.

Heartflow is a publicly traded company (HTFL) that has received international recognition for exceptional strides in healthcare innovation, is supported by medical societies around the world, cleared for use in the US, UK, Europe, Japan and Canada, and has been used for more than 750,000 patients worldwide.

Location: San Francisco, CA (4+ days in office)

Job Description

As a Senior Systems Engineer, you are responsible for the completeness and quality of the system-level design and documentation for Heartflow's core products. You will translate user needs and product requirements into feasible technical requirements, own the functional architecture, and work with members of the R&D team to ensure a traceable, testable, and sustainable design.

At Heartflow, we are working to transform coronary artery disease from the leading cause of death into a condition that can be managed for life. If you are energized by turning clinical and business needs into rigorous, testable requirements, developing a high-quality software development process that captures all system-level dependencies, and partnering across Engineering, Product, Clinical, Regulatory, and Quality to improve the lives of our patients, we want to hear from you.

## Key Responsibilities

- System Architecture & Requirements: Define system requirements and maintain the functional system architecture: the major subsystems, what each must do, and the interfaces and data flows between them.
- Traceability: Ensure traceability between user needs, requirements, and their verification and validation (V&V) evidence, and maintain it as the system evolves.
- System Integration: Identify and resolve complex technical issues across system boundaries, and coordinate dependencies across engineering disciplines.
- Verification & Validation Strategy: Own the system-level V&V strategy: what must be verified or validated, at what level, and what evidence verifies each requirement. Partner with the System Test and Software Engineering teams to ensure requirements are clear and testable.
- Risk Management & Reliability: Identify, analyze, and mitigate technical and product risks. Support failure investigations (e.g., CAPAs, NCs), root cause analysis, corrective actions, and assessments of system reliability and performance.
- Technical Trade-offs: Evaluate and communicate trade-offs involving performance, safety, usability, reliability, scalability, maintainability, schedule, and cost. Use data and engineering judgment to recommend solutions and drive decisions.
- Cross-Functional Technical Leadership: Serve as the technical lead and coordinate cross-functional technical efforts across software, algorithm, quality, regulatory, clinical, product, and operations teams, from concept development through software release and post-market surveillance.
- Systems Engineering Practices: Promote and improve systems engineering practices across the organization, including effective requirements management, risk management, verification planning, traceability, and SDLC improvements. Mentor Systems Engineers as the team scales.

Required Qualifications

- Education: Bachelor's, Master's, or Ph.D. degree in Systems Engineering, Computer Science, Biomedical Engineering, or a related field.
- Experience: 8+ years of industry experience in systems engineering or a related engineering role developing complex software-enabled products.
- Systems Engineering Fundamentals: Demonstrated experience defining functional system architectures, requirements, specifications, and interfaces.
- Integration & Troubleshooting: Proven ability to integrate multidisciplinary systems, analyze complex technical problems, perform root cause analysis, and drive issues to resolution.
- Verification & Risk: Experience defining system-level verification strategies and reviewing test plans and results for requirement coverage, with a working understanding of product risk management and design controls.
- Software Lifecycle Standards: Working knowledge of IEC 62304 and how it governs the medical device software lifecycle, including software safety classification and lifecycle documentation.
- Technical Judgment: Ability to make and communicate sound technical recommendations by balancing user needs, safety, performance, reliability, quality, schedule, and cost.
- Cross-Functional Leadership: Ability to lead technical discussions, influence decisions, and collaborate effectively across software, algorithms, quality, regulatory, clinical, product, and operations teams.
- Technical Communication: Strong written and verbal communication skills, including the ability to communicate complex technical concepts clearly to both technical and non-technical audiences.
- Technical Tools: Experience with requirements management, issue tracking, documentation, or product lifecycle management tools (e.g., Jira, Ketryx). Familiarity with Python or similar tools for analysis and automation is a plus.

## Preferred Qualifications

- Experience developing FDA-regulated SaMD or medical imaging systems, including contributing to regulatory submissions.
- Experience with cardiovascular imaging, CT, CCTA, or clinical software workflows.
- Experience with Model-Based Systems Engineering (MBSE), system modeling, or formal architecture methods.
- Familiarity with ISO 14971, ISO 13485, or comparable risk and quality management standards.
- INCOSE certification (ASEP, CSEP) or demonstrated fluency with INCOSE requirements-writing practices.
- Familiarity with FDA premarket cybersecurity guidance and secure product development practices (e.g., SBOM, threat modeling) for connected SaMD.

A reasonable estimate of the base salary compensation range is $180,000 to $215,000, bonus, and equity. #LI-IB1 Heartflow is an Equal Opportunity Employer. We are committed to a work environment that supports, inspires, and respects all individuals and do not discriminate against any employee or applicant because of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. This policy applies to every aspect of employment at Heartflow, including recruitment, hiring, training, relocation, promotion, and termination.

Positions posted for Heartflow are not intended for or open to third party recruiters / agencies. Submission of any unsolicited resumes for these positions will be considered to be free referrals.

Heartflow has become aware of a fraud where unknown entities are posing as Heartflow recruiters in an attempt to obtain personal information from individuals as part of our application or job offer process. Before providing any personal information to outside parties, please verify the following: A) all legitimate Heartflow recruiter email addresses end with “@heartflow.com” and B) the position described is found on our careers site at [www.heartflow.com/about/careers/](https://www.heartflow.com/about/careers/).

## About Heartflow

## Company Overview
- **One-liner**: Heartflow is a medical technology company that leverages AI to create personalized 3D models of the heart from a single CT scan, enabling clinicians to diagnose, treat, and manage coronary artery disease (CAD) non-invasively.
- **Entity Type**: Public (NASDAQ: HTFL) – IPO in 2025
- **Headquarters**: San Francisco, California, USA
- **Founded**: 2007
- **Founders**: Not publicly listed on primary company pages; the company was founded by a team including Dr. Charles Taylor (inventor of the core technology). *Note: Founders not explicitly named on the main website.*

## Core Business
- **Primary Industry**: Medical Technology / HealthTech / AI-Driven Diagnostics (Cardiology)
- **Target Customers**: B2B – Hospitals, health systems, and cardiology clinics; the end-users are clinicians (cardiologists, radiologists) and the ultimate beneficiaries are patients with suspected or known CAD.
- **Mission/Purpose**: To transform coronary artery disease (CAD) from the leading cause of death into a disease that can be managed for life.

## Products & Services
- **Heartflow One Platform**: The company’s core AI-driven, non-invasive precision coronary care platform. It provides a suite of analyses from a single Coronary CTA (CCTA) scan:
    - **Roadmap™ Analysis**: Visualizes the coronary anatomy and assesses blood flow anywhere in the coronary tree.
    - **FFRct Analysis**: Computes Fractional Flow Reserve from CT, determining the functional significance of a blockage (the original, most established product).
    - **Plaque Analysis**: Quantifies and characterizes plaque to inform risk stratification and disease management.
    - **Type**: SaaS/Software-as-a-Medical-Device (SaMD) integrated into clinical workflow.

## Market Standing
- **Valuation/Market Cap**: Not publicly available from the provided sources. As a recently public company (2025), market cap fluctuates. *Source: LinkedIn indicates a 2025 IPO.*
- **Key Metric**: Over **650,000 patients treated**; over **1,800 institutions** using the platform; **99.5% of U.S. lives covered** for FFRct Analysis.
- **Notable Investors/Partners**: Not listed in the provided search results. The company is now public.
- **Growth Signals**:
    - Supported by scientific statements from the American College of Cardiology (ACC) and American Heart Association (AHA) for personalized CAD management.
    - Late-breaking data at AHA 2025 reinforced the prognostic power of its Plaque Analysis.
    - Growing evidence base across the CAD care continuum, from risk stratification to CT-guided intervention planning.
    - Backed by **>625 peer-reviewed publications**.
    - LinkedIn follower growth: +32% year-over-year, indicating strong brand and market interest.

## Competitive Advantages
- **First-Mover & Gold Standard in FFRct**: Heartflow created the FFRct technology category and has the most robust clinical evidence base (over 625 peer-reviewed publications) and guideline support (ACC/AHA).
- **Integrated Platform (Heartflow One)**: It is the only complete, non-invasive, precision coronary care platform that covers the entire guideline-directed CCTA pathway (anatomy, physiology, and plaque).
- **Massive Clinical & Reimbursement Moat**: Achieving 99.5% U.S. lives covered creates an enormous barrier to entry for competitors, as reimbursement and clinical adoption are already deeply established.
- **AI-First, Non-Invasive Solution**: Replaces invasive diagnostic procedures (cardiac catheterization) with a safer, cheaper, and more comfortable CT scan, aligning with the industry shift toward value-based care.

## Strategic Focus
- **Deepening the Evidence Base**: Continuing to publish clinical data to expand the use cases for its platform (e.g., from diagnosis to guiding interventions).
- **Global Expansion**: Operating in the US, Europe, and Japan, with a focus on expanding access and adoption in these key markets.
- **Platformization**: Moving from a single product (FFRct) to a comprehensive CAD management platform (Heartflow One) that manages patients from screening through treatment.
- **Lifecycle Management**: Shifting the narrative from a one-time diagnostic test to a tool for managing CAD for the patient's entire life.

## Why Work Here
- **Mission-Driven**: The work directly impacts the world's leading cause of death. The company culture emphasizes a "patient-first" mentality.
- **Remote-First Culture**: The company is remote-first with employees across the US, Europe, and Japan. Hubs include San Francisco (HQ), Austin, London, and Tokyo.
- **Strong Benefits**: Medical/Dental/Vision (90% of premium paid by company), 401k match, parental leave, flexible PTO, and an Employee Assistance Program (EAP).
- **Engineering & Clinical Excellence**: A high-caliber team of engineers, data scientists, and clinicians working on cutting-edge AI in a regulated medical environment. The tech stack involves complex 3D modeling, AI/ML, and cloud infrastructure.
- **Growth Stage**: As a recently public company with strong adoption, it offers a balance of startup energy and established market stability. High growth potential in a mission-critical field.

## Sources
1. [heartflow.com (Company Overview)](https://www.heartflow.com/)
2. [heartflow.com (About Us)](https://www.heartflow.com/about/)
3. [heartflow.com (Careers Page)](https://www.heartflow.com/about/careers/)
4. [Greenhouse (Job Board)](http://job-boards.greenhouse.io/heartflowinc)
5. [LinkedIn (Company Profile)](https://www.linkedin.com/company/heartflow-inc)

## Other roles at Heartflow

- [Principal Clinical Engineer – AI Performance & Investigations](https://feeny.ai/job/principal-clinical-engineer-ai-performance-investigations-heartflow-san-atfr06c6ax01) — San Francisco, CA
- [Territory Account Manager - Buffalo, NY](https://feeny.ai/job/territory-account-manager-buffalo-ny-heartflow-buffalo-h0p2jhb6pkah) — Buffalo, NY
- [Senior Platform Engineer (Cloud Foundations)](https://feeny.ai/job/senior-platform-engineer-cloud-foundations-heartflow-san-francisco-mav60dzr09yn) — San Francisco, CA
- [Territory Account Manager - Philadelphia, PA Metro/Main Line](https://feeny.ai/job/territory-account-manager-philadelphia-pa-metro-main-line-heartflow-philadelphia-ysp6xysknb3a) — Philadelphia, PA
- [Senior Product Marketing Manager - Plaque](https://feeny.ai/job/senior-product-marketing-manager-plaque-heartflow-san-francisco-qfjangc6cc17) — San Francisco, CA
- [Field Reimbursement Manager - Southwest](https://feeny.ai/job/field-reimbursement-manager-southwest-heartflow-houston-he81xcxkg1hk) — Houston, TX / Dallas, TX / Austin, TX / Denver, CO / Phoenix, AZ / Scottsdale, AZ
- [Territory Account Manager - North Phoenix, AZ](https://feeny.ai/job/territory-account-manager-north-phoenix-az-heartflow-north-phoenix-jw6fpmptr91r) — North Phoenix, AZ
- [Regional Business Manager - Central](https://feeny.ai/job/regional-business-manager-central-heartflow-st-louis-jv54mkm50c61) — St Louis, MO / Minneapolis, MN
- [Senior Software Engineer](https://feeny.ai/job/senior-software-engineer-heartflow-san-francisco-pztayfdt8kmg) — San Francisco, CA
- [Junior Automation Engineer](https://feeny.ai/job/junior-automation-engineer-heartflow-san-francisco-356cgg58krhn) — San Francisco, CA