---
title: 'Senior Vice President, Clinical Development at Amylyx Pharmaceuticals'
canonical: 'https://feeny.ai/job/senior-vice-president-clinical-development-amylyx-pharmaceuticals-cambridge-84nbxeq02jrk'
type: 'job'
last_seen: '2026-09-08'
---

# Senior Vice President, Clinical Development at Amylyx Pharmaceuticals

- **Company:** Amylyx Pharmaceuticals
- **Location:** Cambridge, MA
- **Compensation:** $416k–$468k
- **Posted:** 2026-06-24
- **Last confirmed live:** 2026-09-08
- **Apply:** https://job-boards.greenhouse.io/amylyx/jobs/6100902004

## Job description

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

The Senior Vice President (SVP) of Clinical Development will provide strategic direction and technical leadership to the clinical development team, including clinical-regulatory development planning, clinical trial design, implementation and execution, clinical data analysis and management, and clinical competitive intelligence. In addition, this individual will participate in various business development evaluations, as applicable.

Overall, the main responsibility will be to provide strategic leadership for the clinical and medical aspects for the various programs and work closely with a cross-functional team to align the clinical development plan with the overall development strategy of the relevant products.   Furthermore, this individual will have the opportunity to oversee the clinical development of multiple product candidates that represent different modalities and are at different stages of development from first in human to pivotal trials.

## Responsibilities

- Strategic Leadership: Develop and implement comprehensive clinical development strategies aligned with Amylyx's mission and business objectives.
- Team Management: Lead and mentor a multidisciplinary team of medical directors, pharmacologists, and clinical development scientists, fostering a culture of collaboration and excellence.
- Clinical Trial Oversight: Oversee the design, execution, and analysis of clinical trials, ensuring adherence to timelines, budgets, and regulatory requirements.
- Regulatory Engagement: Collaborate with regulatory affairs to develop and execute strategies for regulatory submissions and interactions with health authorities.
- Stakeholder Collaboration: Establish and maintain relationships with key opinion leaders, clinical investigators, and external partners to support clinical programs.
- Budget Management: Develop and manage the clinical development budget, ensuring optimal resource allocation and fiscal responsibility.

Required Qualifications

- Educational Background: MD or MD/PhD with specialization in Neurology or Endocrinology preferred.
- Experience: Minimum of 15 years in clinical development within the biotechnology or pharmaceutical industry, with significant experience leading teams in rare disease drug development. Successful BLA/NDA/MAA submission(s) and clinical/medical support of product commercialization preferred.
- Leadership Skills: Proven ability to lead cross-functional teams, foster cross-functional collaboration and manage multiple projects in a fast-paced environment.
- Regulatory Knowledge: In-depth understanding of global regulatory requirements and experience with regulatory interactions and submissions.
- Communication Skills: Excellent verbal and written communication skills, with the ability to effectively present complex information to diverse audiences.

Work Location and Conditions

- At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. Preference may be given to candidates residing within or near the geographic region they support.
- You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
- You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

## Compensation

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.

Estimated Pay Range $416,000—$468,000 USD

To stay connected with us, follow Amylyx Pharmaceuticals on [LinkedIn](https://www.linkedin.com/company/amylyx).

To return to our website please [click here](https://www.amylyx.com/).

Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

## About Amylyx Pharmaceuticals

## Company Overview
- **One-liner**: Amylyx Pharmaceuticals is a clinical-stage pharmaceutical company focused on developing novel therapies for serious diseases with high unmet needs, including neurodegenerative and rare diseases.
- **Entity Type**: Public (NASDAQ: AMLX)
- **Headquarters**: Cambridge, Massachusetts, United States
- **Founded**: 2013
- **Founders**: Josh Cohen and Justin Klee

## Core Business
- Primary industry/industries: Biotechnology / Pharmaceuticals
- Target customers: Patients, healthcare providers, and payers (B2B/B2C); primarily focused on rare and neurodegenerative diseases
- Mission or purpose statement: To develop novel therapies for high unmet needs with urgency, rigorous science, and unwavering commitment to the communities they serve.

## Products & Services
- **AMX0035 (RELYVRIO®/ALBRIOZA)**: An investigational combination therapy for Wolfram syndrome and previously approved for ALS (voluntarily withdrawn after Phase 3 PHOENIX trial did not meet primary endpoint). Still being studied in Wolfram syndrome.
- **Avexitide**: A Phase 3-ready GLP-1 receptor antagonist with FDA Breakthrough Therapy designation for post-bariatric hypoglycemia (PBH) and congenital hyperinsulinism (HI). Dosing in Phase 3 LUCIDITY trial.
- **AMX0114**: An investigational therapy for ALS, currently in Phase 1 LUMINA clinical trial, with FDA Fast Track designation.
- **AMX0318**: A long-acting GLP-1 receptor antagonist in IND-enabling studies for PBH and other rare diseases, developed in collaboration with Gubra A/S.

## Market Standing
- **Valuation/Market Cap**: Not publicly available from provided sources (public company; market cap fluctuates)
- **Key Metric**: Completed IPO on NASDAQ in April 2025 (ticker: AMLX); annual revenue not disclosed (clinical-stage, no approved products currently marketed)
- **Notable Investors/Partners**: Gubra A/S (research collaboration), Dr. Rudy Tanzi (Founding Chair of Scientific Advisory Board)
- **Growth Signals**: Expanded pipeline with avexitide acquisition (July 2024); multiple FDA designations (Fast Track, Orphan Drug); first patients dosed in Phase 1 LUMINA (ALS) and Phase 3 LUCIDITY (PBH); ongoing IND-enabling studies for AMX0318.

## Competitive Advantages
- Focus on high unmet needs with a rigorous, science-driven approach to drug development.
- Strong pipeline diversification across multiple rare and neurodegenerative diseases.
- Experienced team with collective expertise from therapeutic development through commercialization.
- Deep engagement with patient communities and care providers to understand unmet needs.
- Agile, hybrid-remote work environment that attracts and retains top talent.

## Strategic Focus
- Advancing late-stage clinical trials (avexitide Phase 3, AMX0035 Phase 2 in Wolfram syndrome).
- Expanding pipeline through business development and collaborations (e.g., Gubra).
- Leveraging regulatory designations (Breakthrough Therapy, Fast Track, Orphan Drug) to accelerate development.
- Continuing to build a culture of urgency, accountability, and innovation to serve patients with high unmet needs.

## Why Work Here
- **Culture**: Values-driven environment emphasizing accountability, audacity, authenticity, curiosity, and engagement. Rooted in connection with colleagues and the communities served.
- **Work Model**: Hybrid-remote with headquarters in Cambridge, MA. Three annual Anchor Weeks in-person and bi-weekly Amylyx Exchange meetings for connection.
- **Benefits**: Flexible PTO, 5% 401(k) employer contribution, paid parental leave, medical/dental/vision, HSA/FSA, employee assistance program, mobile reimbursement, learning and development program, recognition platform.
- **Engineering/Research Culture**: Emphasis on rigorous science, continuous learning, and generous knowledge sharing. Opportunities to work on cutting-edge therapies from preclinical through commercialization.

## Sources
1. [Amylyx Pharmaceuticals - Our Company](https://www.amylyx.com/our-company)
2. [Amylyx Pharmaceuticals - Careers](https://www.amylyx.com/careers)
3. [Amylyx Pharmaceuticals - Homepage](https://www.amylyx.com/)
4. [Jobs at Amylyx Pharmaceuticals - Greenhouse](https://job-boards.greenhouse.io/amylyx)
5. [Open Positions - Amylyx Pharmaceuticals](https://www.amylyx.com/open-positions)

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