---
title: 'Senior Vice President, Medical Affairs at Tango Therapeutics'
canonical: 'https://feeny.ai/job/senior-vice-president-medical-affairs-tango-therapeutics-boston-yphb7g2va8xb'
type: 'job'
last_seen: '2026-10-20'
---

# Senior Vice President, Medical Affairs at Tango Therapeutics

- **Company:** Tango Therapeutics
- **Location:** Boston, MA
- **Compensation:** $372k–$558k
- **Posted:** 2026-10-19
- **Last confirmed live:** 2026-10-20
- **Apply:** https://job-boards.greenhouse.io/tangotherapeutics/jobs/8033200003

## Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

Tango’s labs and offices are located at 201 Brookline Avenue, in the vibrant Fenway area of Boston, Massachusetts.

Summary

The Senior Vice President (SVP), Global & US Medical Affairs is a critical enterprise leader responsible for defining, building, and executing a unified, world-class medical affairs strategy for Tango Therapeutics on a global scale. As Tango transitions from a research-stage biotech into a fully integrated commercial organization, this executive will build and scale the global and US medical infrastructure required to support the successful launch and lifecycle management of our precision synthetic lethality oral oncology medicines.

Reporting directly to the Chief Commercialization Officer (CCO) and serving as a key member of the Commercial Leadership Team, the SVP will act as the senior physician leader and strategic bridge between clinical development, regulatory affairs, and commercialization. This leader will ensure that the clinical promise of our assets is translated into robust, globally aligned scientific narratives, driving external engagement, evidence generation, and medical education to support patient access and optimize product value worldwide.

Your Role:

Global & US Strategic Leadership and Cross-Functional Integration

- Unified Strategy: Develop, articulate, and execute an integrated Global and US Medical Affairs strategy that aligns with overall corporate objectives, clinical development plans, and global commercial strategies
- Cross-Functional Partnership: Act as a critical strategic medical partner to internal stakeholders (Clinical Development, Regulatory Affairs, Market Access, and Commercial) to ensure that the Global Medical Affairs strategy seamlessly supports early-stage asset development and transitions pipeline assets into successful commercial products
- Commercial Alignment: Provide strategic medical input into global commercial plans, marketing materials, and product positioning to ensure scientific integrity and alignment with clinical realities across all target markets
- Lifecycle Management: Synthesize complex clinical/scientific data and global insights from the medical community to proactively inform clinical trial design, target product profiles, and lifecycle management plans

External Engagement & Global KOL Strategy

- Senior Scientific Voice: Act as the primary physician leader, company spokesperson, and external scientific representative for Tango Therapeutics in both US and international markets
- KOL Development: Identify, cultivate, and maintain strong, collaborative relationships with global and regional key opinion leaders (KOLs), clinical investigators, health systems, medical societies, and academic institutions, particularly within the oncology space
- Field Medical Leadership: Provide strategic direction to the US Field Medical team and guide the expansion of an international field medical strategy, ensuring deep scientific exchange, gathering of clinical insights, and support for investigator-initiated studies (IIS)

Evidence Generation, Medical Communication & Patient Focus

- Evidence Generation (HEOR & RWE): Serve as the medical lead for pre-launch, launch, and post-launch evidence generation globally, and oversee strategies for real-world evidence (RWE) to support the global value proposition of Tango's portfolio
- Scientific Communications: Oversee the development and execution of a strategic global publication plan, scientific communication strategy, and core global materials (e.g., congress plans), ensuring the accurate, timely, and compliant dissemination of clinical data
- Medical Information & Education: Establish and oversee the Medical Information function to provide accurate, balanced responses to unsolicited inquiries globally; manage strategies for continuing medical education and early access/expanded access programs
- Compliance & Governance: Ensure all Medical Affairs activities are conducted with the highest level of integrity and in full compliance with applicable legal, regulatory (e.g., FDA, EMA), and ethical guidelines, providing medical governance oversight for promotional materials

What You Bring:

Education & Experience

- Advanced clinical degree required (MD or DO strongly preferred; PharmD or PhD considered with exceptional clinical oncology experience)
- Specialized clinical training in oncology (Board Certification preferred)
- 15+ years of progressive experience in the biopharmaceutical industry, with significant tenure in senior Medical Affairs leadership roles (VP or above) specifically within oncology or precision medicine
- Demonstrated experience designing and executing Medical Affairs strategies on both a US and Global scale
- Proven track record of supporting successful product launches and managing marketed products in oncology
- Extensive experience recruiting, building, scaling, and mentoring a best-in-class Medical Affairs organization (including field medical, medical information, and HEOR) during a company's transition from clinical stage to commercialization

Core Competencies

- Comprehensive understanding of global clinical development processes, international regulatory environments, and diverse healthcare access landscapes
- Strong business acumen with the ability to effectively collaborate with commercial counterparts and translate complex scientific data into strategic corporate initiatives
- Exceptional executive presence, interpersonal, and communication skills, with an established, high-level network of relationships among global oncology KOLs

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range $372,000—$558,000 USD

## About Tango Therapeutics

## Company Overview
- **One-liner**: Tango Therapeutics is a clinical-stage biotechnology company leveraging the principle of synthetic lethality to discover and develop next-generation precision cancer medicines for genetically defined patient populations.
- **Entity Type**: Public (NASDAQ: TNGX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2017
- **Founders**: Not publicly disclosed (launched by Third Rock Ventures)

## Core Business
- **Primary industry/industries**: Biotechnology, Precision Oncology, Drug Discovery & Development
- **Target customers**: B2B (pharma partnerships, clinical trial sites); ultimate customers are cancer patients with specific genetic tumor profiles
- **Mission or purpose statement**: "Discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways… building a road map to cures that will transform the lives of patients and their families." [tangotx.com](https://www.tangotx.com/join-us/)

## Products & Services
- **Vopimetostat (PRMT5 inhibitor)**: A clinical-stage, wholly-owned program targeting MTAP-deleted cancers, including pancreatic, lung, and glioblastoma. Currently in Phase 1/2 trials. [tangotx.com](https://www.tangotx.com/pipeline/)
- **TNG456 (PRMT5 inhibitor)**: A next-generation PRMT5 inhibitor for MTAP-deleted cancers, currently in pre-clinical development.
- **Daraxonrasib (RAS inhibitor)**: A combination therapy (with vopimetostat) for MTAPdel/RASmut pancreatic and lung cancers. Recently reported a 92% objective response rate in pancreatic cancer in a Phase 1/2 trial. [tangotx.com](https://www.tangotx.com/)
- **CRISPR-based Target Discovery Engine**: A proprietary platform for identifying novel synthetic lethal targets, enabling a robust pipeline of wholly-owned programs.

## Market Standing
- **Valuation/Market Cap**: ~$1.05 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Key Metric**: Annual Revenue of ~$62.4 million; Total Funding raised ~$901 million (including post-IPO). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Notable Investors/Partners**: Third Rock Ventures (lead Series A), Boxer Capital (lead Series B), BCTG Acquisition Corp (parent). Strategic partners include pharma and biotech companies (collaborations under active exploration). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Growth Signals**: Completed a $600 million upsized public offering in June 2026; strong clinical data (92% ORR in pancreatic cancer); pipeline expanding into glioblastoma; headcount growth in job postings (+400% YoY in active roles). [tangotx.com](https://www.tangotx.com/)

## Competitive Advantages
- **Synthetic Lethality Expertise**: A deep, proprietary understanding of CRISPR-based target discovery to identify novel vulnerabilities in cancers with tumor suppressor gene loss, undruggable oncogenes, and immune evasion mechanisms.
- **Genetically Defined Patient Selection**: All programs are designed for well-defined patient populations with clear biomarkers, increasing the probability of clinical success and reducing trial risk.
- **Wholly-Owned Pipeline**: Unlike many biotechs that license out rights, Tango retains full ownership of its lead programs, capturing maximum value.
- **Strong Financial Position**: With over $1B in market cap and a recent $600M offering, the company is well-capitalized to advance its pipeline through pivotal trials.

## Strategic Focus
- **Current priorities**: Advancing vopimetostat and daraxonrasib into Phase 3 trials for pancreatic and lung cancers; expanding the pipeline into glioblastoma; continuing to discover and validate new synthetic lethal targets; building out commercial manufacturing and clinical operations infrastructure.
- **Direction for growth**: Becoming a fully-integrated biotechnology company capable of bringing its own medicines to market, while selectively pursuing strategic collaborations to expand reach.

## Why Work Here
- **Culture highlights**: Emphasizes "urgency + compassion," "courage + leadership," "spirit + resilience," and "embrace individuality and face challenges together." Described as a team of "passionate problem solvers" who are "all in for exciting science and changing lives." [tangotx.com](https://www.tangotx.com/join-us/)
- **Remote/hybrid/office policy**: Primarily on-site at Boston HQ (201 Brookline Ave, Suite 901, Boston, MA). Roles appear to be Boston-based, though some field-based positions (e.g., Medical Science Liaisons) are remote.
- **Notable perks or engineering culture**: High scientific ambition with a clear patient-first mission; strong leadership team with deep oncology experience; active hiring across clinical operations, biostatistics, medical affairs, and legal/compliance; 15+ active job postings with significant YoY growth in roles. [greenhouse.io](http://job-boards.greenhouse.io/tangotherapeutics)
- **Workforce**: ~129 employees, with a mix of research (26%), medical (12%), and operations roles. Notable alumni from Novartis, Vertex, Takeda, and Broad Institute. [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)

## Sources
1. [Tango Therapeutics Official Website](https://www.tangotx.com/)
2. [Tango Therapeutics Careers Page (Greenhouse)](http://job-boards.greenhouse.io/tangotherapeutics)
3. [Tango Therapeutics LinkedIn Profile](https://www.linkedin.com/company/tango-therapeutics)
4. [Tango Therapeutics Pipeline Page](https://www.tangotx.com/pipeline/)
5. [Tango Therapeutics Join Us Page](https://www.tangotx.com/join-us/)

## Other roles at Tango Therapeutics

- [Associate Director, Statistical Programming](https://feeny.ai/job/associate-director-statistical-programming-tango-therapeutics-boston-dkt87pa41pb6) — Boston, MA
- [Associate Director, Operational Excellence](https://feeny.ai/job/associate-director-operational-excellence-tango-therapeutics-boston-at4qdd9qfq1w) — Boston, MA
- [Executive Director, Commercial Law/Commercial Contracts](https://feeny.ai/job/executive-director-commercial-law-commercial-contracts-tango-therapeutics-boston-4rgpv55eb66w) — Boston, MA
- [Director, Intellectual Property](https://feeny.ai/job/director-intellectual-property-tango-therapeutics-boston-pesyhn9k10dj) — Boston, MA
- [Senior Clinical Data Manager](https://feeny.ai/job/senior-clinical-data-manager-tango-therapeutics-boston-xk614h7zhf91) — Boston, MA
- [Manager, GMP Quality](https://feeny.ai/job/manager-gmp-quality-tango-therapeutics-boston-70t57986x902) — Boston, MA
- [Executive Director, Commercial Strategy & Execution](https://feeny.ai/job/executive-director-commercial-strategy-execution-tango-therapeutics-boston-y7x7vkeeenkd) — Boston, MA
- [Head of Marketing & Sales](https://feeny.ai/job/head-of-marketing-sales-tango-therapeutics-boston-ex81335qs4hc) — Boston, MA
- [Head of Insights & Analytics](https://feeny.ai/job/head-of-insights-analytics-tango-therapeutics-boston-4f5kkx80kztw) — Boston, MA
- [Senior Vice President, Market Access](https://feeny.ai/job/senior-vice-president-market-access-tango-therapeutics-boston-47tt1fw4qxxq) — Boston, MA