---
title: 'Site Reliability Engineer at Watershed Informatics'
canonical: 'https://feeny.ai/job/site-reliability-engineer-watershed-informatics-cambridge-azkdhwden9h4'
type: 'job'
last_seen: '2026-09-11'
---

# Site Reliability Engineer at Watershed Informatics

- **Company:** Watershed Informatics
- **Location:** Cambridge, MA
- **Posted:** 2024-06-27
- **Last confirmed live:** 2026-09-11
- **Apply:** https://boards.greenhouse.io/watershed/jobs/6019484003?gh_jid=6019484003

## Job description

## About Watershed

Our vision is to become the leading biocomputing platform. The future of biology is in big data analysis, and we are on a mission to accelerate digital drug discovery with the Watershed platform. Watershed enables scientists to conduct all essential analysis — from lab data to plot — with a single software platform.

We have attracted some of the best bioinformatics, engineering, and commercial talent, and we are growing! Join a team that’s intellectually curious with a bias for action, headquartered in Cambridge, Massachusetts, composed of people who have come together to enable outcomes while empowering the research of all those committed to changing lives — all while bringing transformational change to a $40 billion industry.

## Role

Linux Systems Engineers at Watershed engineer infrastructure to meet the high-performance computing needs of modern biology. Designing systems that keep pace with the explosive growth in the kinds and size of biological data, you will work in a highly-customized bare metal environment where our biocomputing platform and analyses run at scale. You will be tasked with engineering a new cloud experience while enabling our technology evolution in a disciplined way.

## Responsibilities

- Build, manage, and deploy a large fleet of Linux servers
- Research new technologies and solutions, implement them or build better
- Be the connection between hardware and software
- Monitor system performance and manage capacity.
- Fix and analyze technical incidents, solve ad hoc technical problems.

## Qualifications

- Experience composing infrastructure-as-code for a modern environment
- Demonstrate a software developer mindset, building tools when necessary
- Knowledge of virtualization, networking, and Linux Kernel internals
- Ability to clearly communicate your thoughts, ask the right questions, and defend your views
- Responsibility and ownership over your domain.

## About Watershed Informatics

## Company Overview
- **One-liner**: Watershed Informatics provides a unified, cloud-based platform for biological data analysis, discovery, and collaboration, enabling scientists to scale drug discovery and development pipelines.
- **Entity Type**: Private (Series A)
- **Headquarters**: Cambridge, Massachusetts, United States
- **Founded**: 2019
- **Founders**: Jonathan Wang and Mark Kalinich

## Core Business
- **Primary industry/industries**: Bioinformatics / Biotechnology Research
- **Target customers**: B2B – life sciences organizations (pharma, biotech, academic labs) of all sizes.
- **Mission or purpose statement**: Transform biomedical research by providing a complete, scalable solution for biological data analysis.

## Products & Services
- **Watershed Platform**: A SaaS platform that enables secure access, management, and analysis of all biological data types (genomics, proteomics, transcriptomics, etc.). Features include customizable AI tools, notebooks, collaborative workflows, and supercomputing infrastructure. [watershed.bio](https://watershed.bio/)
- **Cloud Data Lab**: An end-to-end bio-IT managed service for mission-critical bioinformatics analyses at reduced cost and complexity. [builtin.com](https://builtin.com/company/watershed-informatics)
- **Training & Support**: Onboarding training and hourly support from PhD-level bioinformaticians, with custom plans for startups and academia. [watershed.bio/faqs](https://watershed.bio/faqs)

## Market Standing
- **Valuation/Market Cap**: Not publicly available
- **Key Metric**: Total Funding $16.2M (Seed $1.7M in 2021, Series A $14.5M in 2023 led by Canvas Prime) | Annual Revenue $3.4M (LinkedIn estimate)
- **Notable Investors/Partners**: Canvas Prime (lead), 4 investors in Series A; Advisors: Frank Moss, Ph.D. (Harvard Medical School, MGH Cancer Center) and Michael Lawrence, Ph.D. (Jackson Laboratory). Clients include Revitope Oncology, SQZ Biotech, and Rarebase. [linkedin.com](https://www.linkedin.com/company/watershed-bio) | [watershed.bio/company](https://watershed.bio/company)
- **Growth Signals**: Active hiring (8+ open roles on Built In in engineering, bioinformatics, and marketing), expanding library of analysis workflows and automation features.

## Competitive Advantages
- End-to-end platform supporting all biological data types (multi-omics, imaging, etc.) in one environment.
- Security built by CEO with quantitative finance background.
- Scalable supercomputing infrastructure – processes hundreds of terabytes of data monthly.
- Dedicated bioinformatics support (training, custom workflows) for users of all skill levels.
- Integrations with tools like Benchling, RStudio, and Alphafold.

## Strategic Focus
- Continue building the platform to drive “a new era of scientific breakthroughs” through expanded workflows, automation, and AI capabilities.
- Deepen partnerships with both industry and academia to accelerate drug discovery.

## Why Work Here
- **Culture**: Close-knit, interdisciplinary team of experts in bioinformatics, engineering, and biology – described as “collaborative growth-forward environment.” [watershed.bio/company](https://watershed.bio/company)
- **Remote/Hybrid/Office**: Headquarters in Cambridge, MA (in-office for many roles). Employees located across the country – likely flexible for some positions.
- **Notable perks**: Opportunity to work at the intersection of biology and technology, direct impact on biomedical research, access to leading experts as advisors, and fast-growing startup environment.

## Sources
1. [watershed.bio](https://watershed.bio/)
2. [watershed.bio/company](https://watershed.bio/company)
3. [linkedin.com](https://www.linkedin.com/company/watershed-bio)
4. [builtin.com](https://builtin.com/company/watershed-informatics)
5. [watershed.bio/faqs](https://watershed.bio/faqs)

## Other roles at Watershed Informatics

- [Customer Success Engineer, Bioinformatics](https://feeny.ai/job/customer-success-engineer-bioinformatics-watershed-informatics-cambridge-96kvazwg6znk) — Cambridge, MA
- [Performance Marketing Analyst](https://feeny.ai/job/performance-marketing-analyst-watershed-informatics-cambridge-wagec58twmgf) — Cambridge, MA
- [Senior Software Engineer, Product](https://feeny.ai/job/senior-software-engineer-product-watershed-informatics-boston-nwymtcfdr23d) — Boston, MA
- [Infrastructure Engineer](https://feeny.ai/job/infrastructure-engineer-watershed-informatics-cambridge-2h7xcm8xtya4) — Cambridge, MA
- [Software Engineer, UI](https://feeny.ai/job/software-engineer-ui-watershed-informatics-boston-mtrnde7n6w1y) — Boston, MA
- [Software Engineer](https://feeny.ai/job/software-engineer-watershed-informatics-boston-2mbb9jx7qzy8) — Boston, MA
- [High Performance Computing Engineer](https://feeny.ai/job/high-performance-computing-engineer-watershed-informatics-boston-r4k7m9wb5hsh) — Boston, MA
- [Site Reliability Engineer](https://feeny.ai/job/site-reliability-engineer-singlestore-linkedin-portugal-r7dtrfaa17rn) — Portugal
- [Site Reliability Engineer](https://feeny.ai/job/site-reliability-engineer-genesis-london-cpq05vt4mpzk) — London, United Kingdom
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