---
title: 'Sr. Clinical Supply Chain Manager at 4D Molecular Therapeutics'
canonical: 'https://feeny.ai/job/sr-clinical-supply-chain-manager-4d-molecular-therapeutics-emeryville-0x65hc8a3mcd'
type: 'job'
last_seen: '2026-11-08'
---

# Sr. Clinical Supply Chain Manager at 4D Molecular Therapeutics

- **Company:** 4D Molecular Therapeutics
- **Location:** Emeryville, CA
- **Work type:** remote
- **Posted:** 2026-11-03
- **Last confirmed live:** 2026-11-08
- **Apply:** https://4dmoleculartherapeutics.com/careers/?gh_jid=4750603005

## Job description

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF biologics (aflibercept and anti-VEGF-C) with a single intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration and the second indication is diabetic macular edema, which are both in Phase 3 development. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery.

We are taking genetic medicine to new heights and into new disease areas to overcome challenges not addressed by existing medicines. This incredible challenge drives our relentless and talented team. Our people are the essence of our inspiring, innovative and collaborative environment that encourages individual contributions and provides opportunities for career development. We seek the best in the industry who identify with our mission and our bold and innovative results-driven approach. Our Core Values drive the way we work together:

- Dare to Cure
- Break Boundaries
- Beyond Yourself
- Prepare & Execute Relentlessly

Join us in creating the future of genetic medicine.

## GENERAL SUMMARY

The Sr. Clinical Supply Chain Manager is a senior, hands-on, study supply lead responsible for the strategy, start-up, execution, and lifecycle management of global clinical supplies, with primary emphasis on study start-up activities for complex programs. Working with a high degree of independence, this role serves as the sponsor-side clinical supply representative on cross-functional study teams and translates protocol, enrollment, country, manufacturing, release, and regulatory assumptions into an executable supply strategy. This role will also need to have an in-depth understanding of the required study start-up activities and can anticipate potential supply impacts.

The role is expected to lead multiple global study start-ups from protocol development through First Patient, First Visit (FPFV) readiness, establish scalable supply models, anticipate risks before they affect study milestones, and provide clear recommendations to senior stakeholders. The position partners closely with Clinical Operations, CMC/Manufacturing, Quality, Regulatory Affairs, Clinical Science, Finance, and external vendors and service providers.

The successful candidate operates as a study supply lead, not solely as a logistics coordinator. They can enter a complex Phase 3 start-up, quickly establish the assumptions and critical path, create an integrated plan, drive cross-functional decisions, and escalate early with practical options. They combine strategic planning with hands-on execution and can stabilize a study before transitioning routine operational management as appropriate.

## MAJOR DUTIES & RESPONSIBILITIES:

Study Start-Up Leadership

- Own the clinical supply workstream for complex global study start-up, from protocol concept and country strategy through site activation and First Patient, First Visit (FPFV) readiness.
- Build and maintain integrated start-up plans with the team covering demand assumptions, manufacturing and release, packaging and labeling, IRT cross-configuration, depot activation, import/export readiness, site supply, comparator and ancillary sourcing, and contingency stock.
- Assess protocol design, treatment arms, randomization, visit schedules, titration or rescue requirements, enrollment ramps, screen failure, dropout, resupply logic, and geographic expansion for supply impact.
- Define supply readiness criteria, identify critical-path dependencies, challenge unrealistic assumptions, and drive decisions and escalations across study teams.
- Lead supply scenario planning for accelerated enrollment, manufacturing or release delay, expiry constraints, regulatory delay, country additions, protocol amendments, and other material changes.

Clinical Supply Strategy and Forecasting

- Develop and own end-to-end supply strategies for investigational product, comparator, diluent, ancillary materials, and other protocol-required supplies.
- Create demand forecasts and supply plans using enrollment, dosing, cohort, country, site, lead-time, expiry, and inventory assumptions; document assumptions and reconcile forecast changes.
- Optimize inventory and resupply parameters to protect patient continuity while minimizing waste, overage, expiry exposure, and avoidable manufacturing burden.
- Integrate drug product availability, packaging capacity, QA release, shelf life, stability projections, and regulatory constraints into study-level and portfolio plans.

IRT, Distribution, and Inventory Oversight

- Provide business ownership for clinical supply aspects of IRT design, including supply algorithms, depot and site resupply, inventory status, expiry controls, kit management, UAT, go-live readiness, and ongoing data review.
- Establish and oversee global depot and distribution strategies, including lane qualification, cold-chain requirements, import/export documentation, customs readiness, and country-specific requirements.
- Monitor inventory health, shipment performance, accountability, returns, reconciliation, destruction, temperature excursions, and other supply exceptions; ensure timely investigation and resolution.

Vendor and Cross-Functional Leadership

- Lead selection, onboarding, governance, and performance management of packaging and labeling vendors, depots, couriers, comparator and ancillary suppliers, IRT providers, and other clinical supply partners.
- Develop RFP scope, evaluate proposals, support contract and change-order negotiations, manage budgets and forecasts, and hold vendors accountable for quality, cost, schedule, and issue resolution.
- Represent Clinical Supply Chain on study and program teams; communicate status, assumptions, trade-offs, decisions, and risks to operational and senior stakeholders.
- Mentor colleagues and provide subject-matter guidance on complex start-up and supply issues; lead work through influence in a matrix environment.

Quality, Compliance, and Operational Excellence

- Ensure activities are performed in accordance with applicable GxP and GDP requirements, company procedures, quality agreements, and relevant global regulatory expectations.
- Maintain inspection-ready supply plans, forecasts, decisions, vendor oversight records, inventory documentation, and traceability of clinical materials.
- Contribute to deviations, investigations, CAPAs, change controls, audits, and inspection support involving clinical supply processes or vendors.
- Develop and improve SOPs, templates, governance, metrics, and business processes that enable consistent execution across studies and the portfolio.
- Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time

## QUALIFICATIONS:

Education:

- Bachelor's degree in supply chain, life sciences, pharmacy, or a related discipline; advanced degree or relevant professional certification is preferred.

Experience:

- Minimum 8 years of progressive experience in clinical supply chain, clinical operations supply, or a closely related discipline within biotechnology or pharmaceuticals with preferably 4 years of experience working with IRT.

Other Qualifications/Skills:

- Substantial sponsor-side experience and demonstrated ownership of end-to-end clinical supply activities, rather than experience limited to a single vendor function or execution step.
- Proven experience leading at least one complex, global Phase 3 study start-up through supply readiness; experience with multi-country, blinded, comparator-controlled, cold-chain, biologic, or advanced-therapy studies is strongly preferred.
- Demonstrated expertise in demand forecasting, packaging and labeling, IRT supply design and UAT, global distribution, depot strategy, import/export, inventory and expiry management, accountability, returns, and destruction.
- Working knowledge of cGMP, GDP, GCP interfaces, FDA and EMA expectations, and international clinical supply requirements. Experience with GMO requirements and APAC, European, and other global markets is preferred.
- Experience selecting and governing external partners, managing budgets and contracts, resolving complex deviations or supply disruptions, and presenting risk-based recommendations to senior stakeholders.
- Advanced project leadership, analytical, communication, negotiation, and problem-solving skills, with the judgment to operate independently in a fast-paced, matrixed environment.
- Proficiency with IRT, demand-planning and inventory data, and Microsoft Excel and PowerPoint. Experience creating dashboards or portfolio-level supply reporting is preferred. Takes initiative in identifying potential issues and implementing timely corrective actions.

Travel:

- Remote or Hybrid role with onsite presence as needed.
- Periodic domestic or international travel may be required to support vendor oversight, study start-up, audits, or critical program activities.

Physical Requirements and Working Conditions:

- Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
- Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).

Base salary compensation range: $162,000 - $189,000

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

## About 4D Molecular Therapeutics

## Company Overview
- **One-liner**: 4D Molecular Therapeutics is a late-stage clinical biotechnology company inventing and developing customized genetic medicines using a proprietary vector evolution platform to treat large-market diseases.
- **Entity Type**: Public (NASDAQ: FDMT)
- **Headquarters**: Emeryville, California, United States
- **Founded**: 2013
- **Founders**: David Kirn, MD (Co-Founder, President, and CEO)

## Core Business
- **Primary industry**: Biotechnology / Genetic Medicine / Gene Therapy
- **Target customers**: B2B (partnerships with other biopharma companies) and B2C (patients with retinal and pulmonary diseases)
- **Mission or purpose statement**: "To unlock the full potential of genetic medicines for large market diseases" by harnessing directed evolution to invent customized and enhanced vectors for transformative products.

## Products & Services
- **4D-150**: A clinical-stage genetic medicine candidate for retinal vascular diseases (wet age-related macular degeneration and diabetic macular edema). It is designed as a single, routine, low-dose intravitreal injection that provides multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C). Currently in Phase 3 clinical trials (4FRONT-1 and 4FRONT-2) for wet AMD and Phase 1/2 for DME.
- **4D-710**: An investigational genetic medicine candidate for cystic fibrosis lung disease. It uses the A101 vector for aerosol delivery of a corrective CFTR transgene (CFTR∆R) and is designed for patients ineligible for or who have discontinued CFTR modulator therapy. Currently in Phase 1/2.
- **4D-175**: A preclinical candidate for geographic atrophy (a form of dry AMD) using the R100 vector to deliver a shortened form of human complement factor H (sCFH) to restore normal complement regulation.
- **4D-725**: A preclinical candidate for alpha-1 antitrypsin (A1AT) lung disease using the A101 vector for aerosol delivery.

## Market Standing
- **Valuation/Market Cap**: $756.4 million (as of latest data from LinkedIn)
- **Key Metric**: Annual Revenue of $85.2 million (as of latest data from LinkedIn)
- **Notable Investors/Partners**: The company is publicly traded (IPO in 2020). Key partnerships are sought for pipeline candidates like 4D-175 and 4D-725.
- **Growth Signals**: The company is a late-stage biotech with two Phase 3 trials (4FRONT-1 and 4FRONT-2) for its lead candidate 4D-150 in wet AMD, and a Phase 1/2 trial for 4D-710 in cystic fibrosis. The company has a presence in Ecuador, France, and India. LinkedIn followers grew 24.7% year-over-year.

## Competitive Advantages
- **Proprietary Vector Platform (Therapeutic Vector Evolution)**: The company uses directed evolution to create customized and proprietary AAV vectors (e.g., R100 for retina, A101 for lung) that are optimized for specific tissues and routes of administration, which is a significant differentiator from standard gene therapy approaches.
- **Large-Market Focus**: Unlike many gene therapy companies targeting ultra-rare diseases, 4DMT is focused on large-market indications (wet AMD, DME, cystic fibrosis) with high unmet need, offering a potentially massive commercial opportunity.
- **Durable, Single-Dose Therapies**: Their products are designed to provide multi-year efficacy from a single injection, which could dramatically reduce treatment burden for patients compared to current standard-of-care (e.g., frequent eye injections for wet AMD).

## Strategic Focus
- **Advancing Late-Stage Pipeline**: The primary focus is executing the Phase 3 programs for 4D-150 in wet AMD and progressing 4D-710 in cystic fibrosis.
- **Expanding Indications**: The company is exploring 4D-150 for diabetic macular edema (DME) and seeking partnerships to advance 4D-175 (geographic atrophy) and 4D-725 (A1AT deficiency).
- **Platform Expansion**: Continuing to leverage the Therapeutic Vector Evolution platform to develop new genetic medicines for other large-market diseases.

## Why Work Here
- **Mission-Driven Culture**: The company is deeply committed to "daring to cure" and unlocking the potential of genetic medicine for patients with devastating diseases. Core values include "Dare to Cure," "Break Boundaries," "Prepare & Execute Relentlessly," and "Beyond Yourself."
- **Innovative Science**: Employees work on cutting-edge science at the intersection of gene therapy, vector engineering, and clinical development, tackling some of the biggest challenges in medicine.
- **Collaborative Environment**: The company emphasizes teamwork, internal and external collaboration, and a culture that empowers innovation.
- **Location & Perks**: Based in Emeryville, CA (San Francisco Bay Area). The company offers a competitive benefits package and a dynamic, collaborative environment.
- **Diversity & Inclusion**: 4DMT champions diversity, equity, and inclusion through an employee-led initiative called "4Diversity," which partners with charitable organizations and focuses on social equity.
- **Work Authorization**: Candidates must be authorized to work in the U.S. The company does not sponsor new nonimmigrant visa status petitions but welcomes candidates who require transfers or extensions.

## Sources
1. [4dmoleculartherapeutics.com](https://4dmoleculartherapeutics.com/)
2. [4dmoleculartherapeutics.com - About](https://4dmoleculartherapeutics.com/about/)
3. [4dmoleculartherapeutics.com - Careers](https://4dmoleculartherapeutics.com/careers/)
4. [4dmoleculartherapeutics.com - Pipeline](https://4dmoleculartherapeutics.com/pipeline/)
5. [LinkedIn - 4D Molecular Therapeutics](https://www.linkedin.com/company/4d-molecular-therapeutics-llc)

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