---
title: 'Sr. Manager, Analytical Sciences at Genetix Biotherapeutics'
canonical: 'https://feeny.ai/job/sr-manager-analytical-sciences-genetix-biotherapeutics-somerville-jt9ywj9177mm'
type: 'job'
last_seen: '2026-11-09'
---

# Sr. Manager, Analytical Sciences at Genetix Biotherapeutics

- **Company:** Genetix Biotherapeutics
- **Location:** Somerville, MA
- **Compensation:** $150k–$175k
- **Posted:** 2026-11-09
- **Last confirmed live:** 2026-11-09
- **Apply:** https://job-boards.greenhouse.io/genetixbiotherapeutics/jobs/8350740

## Job description

## About Genetix Biotherapeutics

At Genetix Biotherapeutics every role has meaning, every team member is respected, and every day is a chance to make a difference. When you join Genetix, you're not just landing a new role, you become part of a company that's pursuing curative gene therapies to give patients and their families more days. We are doers, thinkers and collaborators who embrace and live by our values:

Our innovation is rooted in the diversity of our teams and results are achieved through cooperation and the integration of multiple viewpoints. This is personal and we approach every challenge with radical care.

This is a full-time, lab-based position located at our Somerville, Massachusetts office. The role requires an onsite presence five days per week and is not eligible for remote or hybrid work. Candidates must reside within a commutable distance of the Somerville office.

## SUMMARY

The Senior Manager, Analytical Sciences will provide scientific and technical leadership for analytical activities supporting our gene therapy product portfolio across internal and external development and testing networks. This individual contributor role will be responsible for overseeing analytical program execution, driving analytical lifecycle management, leading the transfer and maintenance of analytical methods at external testing laboratories, and serving as a key liaison with CDMO, CRO, and QC partners. While maintaining sufficient technical depth to support and lead internal analytical activities, including hands-on assay development, troubleshooting, and characterization studies, the role is primarily focused on ensuring analytical readiness, method performance, and strategic alignment across development and commercial testing environments.

The ideal candidate will bring strong technical expertise in cell and gene therapy analytical development, a proven track record of assay troubleshooting, method transfer, and external partner oversight, and the scientific rigor required to bridge early development and commercial QC operations.

## RESPONSIBILITIES

Tech Transfer & Analytical Lifecycle Management

- Serve as the analytical lead for external testing laboratories, providing scientific oversight of analytical execution, method performance, lifecycle management activities, and continuous improvement initiatives.
- Develop and maintain strong working relationships with CDMO, CRO, and contract testing partners to ensure consistent method execution and analytical performance.
- Lead governance activities related to analytical methods including transfers, validations, investigations, method revisions, trend monitoring, and change assessments.
- Evaluate assay suitability throughout the product lifecycle and identify opportunities for optimization, modernization, or platform replacement.
- Support analytical strategy and long-term control strategy development for clinical and commercial programs.
- Act as the technical subject matter expert (SME) to support troubleshooting, OOS/OOT investigations, and root-cause analyses with external CDMO/CRO partners leveraging deep understanding of laboratory operations, assay execution, and analytical method performance.
- Author method transfer protocols and oversee the technical execution of method validation at external sites, ensuring compliance with regulatory standards.

Cross-Functional Leadership & Compliance

- Collaborate across the CMC team to author and review technical reports, SOPs, and analytical data packages supporting regulatory submissions (IND/BLA).
- Provide technical leadership across internal and external testing organizations to ensure scientifically sound and compliant execution of analytical activities.
- Coordinate analytical deliverables, testing timelines, and resource planning across internal teams and external testing partners to support program objectives.

Analytical Execution & Support

- Provide technical oversight of analytical activities performed internally and externally to support development, characterization, comparability, and commercialization objectives.
- Implement analytical strategies within the lab to ensure tight alignment with process development milestones and regulatory guidelines.
- Partner closely with Process Development, Technical Operations, Quality, Regulatory, and external testing organizations to ensure analytical support for process characterization, comparability, validation, and lifecycle management activities.
- Contribute to the life cycle management of analytical control strategies by identifying, troubleshooting, and proposing assay updates or modern replacements.
- Execute and interpret characterization studies to support strategic, data-driven decisions related to process understanding and comparability.

Assay Development & Innovation

- Provide scientific leadership and hands-on technical contribution toward analytical method development, qualification, transfer, and implementation activities, leveraging internal and external capabilities as appropriate.
- Assess emerging analytical technologies and platform improvements that enhance assay robustness, operational efficiency, and long-term sustainability across the testing network.
- Develop new methods with a "right first time" mentality to ensure seamless, robust transition to a downstream GMP environment.

## Qualifications

- Education: Ph.D. in Biochemistry, Molecular Biology, Analytical Chemistry, or a related scientific discipline with 5+ years of biopharmaceutical industry experience; or an M.S. with 8+ years of relevant industry experience.
- Track Record: Proven success leading analytical method transfers, validations, investigations, lifecycle management activities, and external partner oversight within cell and gene therapy or biopharmaceutical environments. Experience managing analytical activities across multiple external testing organizations is strongly preferred.
- Demonstrated experience supporting analytical control strategies, method lifecycle management, trend monitoring programs, change control assessments, and regulatory inspections or filings.
- Technical Expertise: Deep, hands-on mastery of cell and gene therapy analytical techniques (e.g., Cell-based Potency assays, ELISA, UPLC, Multicolor Flow Cytometry, or ddPCR/qPCR,). Prior hands-on experience with CD34+ cell lineages and/or viral vector characterization is highly preferred.
- Communication: Exceptional verbal and written communication skills, with the ability to clearly translate complex, bench-level analytical data into actionable insights for cross-functional CMC teams.

Additional Information

The pay transparency range provided below is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. We may ultimately pay more or less than the posted range, and the range may be modified in the future. This role is eligible for an annual bonus and long-term incentive. Actual base salary pay will be based on several factors, including but not limited to experience, skills, relevant education/qualifications, external market, internal equity, and other job-related factors permitted by law.

Genetix’s total rewards package also provides employees with a comprehensive and competitive benefits suite to support a variety of employee needs. These benefits include comprehensive health, life and disability insurance, employer-matched 401(k) plan, lifestyle spending account, flexible time-off + paid holidays and winter holiday period, tuition reimbursement & loan repayment assistance, paid parental leave, paid onsite parking, commuter subsidy, and much more.

Pay Transparency $150,000—$175,000 USD

Genetix is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.

## About Genetix Biotherapeutics

## Company Overview
- **One-liner**: Genetix Biotherapeutics (formerly bluebird bio) is a commercial-stage biotechnology company dedicated to developing and delivering one-time, curative genetic therapies for patients with severe rare genetic diseases.
- **Entity Type**: Private (taken private in June 2025 after a sale to new ownership)
- **Headquarters**: Somerville, Massachusetts, USA (with a presence in the Netherlands)
- **Founded**: 1992 (founded as Genetix Pharmaceuticals; rebranded to bluebird bio in 2010; rebranded back to Genetix Biotherapeutics in September 2025)
- **Founders**: Not publicly disclosed; the company was originally founded as Genetix Pharmaceuticals in 1992.

## Core Business
- **Primary Industries**: Biotechnology, Gene Therapy, Rare Disease Therapeutics
- **Target Customers**: B2B (healthcare providers, qualified treatment centers, payers/insurers) and B2C (patients with sickle cell disease, β-thalassemia, and cerebral adrenoleukodystrophy)
- **Mission**: "To transform lives through curative therapies for patients with rare, genetic diseases."

## Products & Services
- **LYFGENIA™ (lovotibeglogene autotemcel / lovo-cel)**: An FDA-approved, one-time gene therapy for patients 12 years and older with sickle cell disease. It works by adding functional copies of a modified β-globin gene into the patient's own blood stem cells.
- **ZYNTEGLO™ (betibeglogene autotemcel)**: An FDA-approved, one-time gene therapy for patients with β-thalassemia who require regular blood transfusions. It adds functional copies of a modified β-globin gene into the patient's own blood stem cells.
- **SKYSONA™ (elivaldogene autotemcel)**: An FDA-approved, one-time gene therapy for boys with cerebral adrenoleukodystrophy (CALD), a rare, progressive genetic brain disease. It adds a functional copy of the ABCD1 gene into the patient's own blood stem cells.
- **Patient Support Program**: Personalized assistance for patients and families navigating the treatment journey, including insurance questions, treatment center coordination, and one-on-one support.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed (privately held after take-private transaction in June 2025)
- **Key Metrics**:
  - **Annual Revenue**: Not publicly disclosed (but the company reported strong revenue growth in 2025 and achieved its **first ever profitable quarter** in that year)
  - **Total Funding**: Not publicly disclosed (new investors provided "significant capital" to support operational objectives following the take-private transaction)
- **Notable Investors/Partners**: New ownership group (undisclosed); manufacturing partners include **Minaris**, **Lonza**, and **MilliporeSigma** (the U.S. and Canada business of Merck KGaA, Darmstadt, Germany)
- **Growth Signals**:
  - **2025 commercial performance**: >100 patients treated in the U.S.; >150 patients completed their first cell collection cycle; 70 active Qualified Treatment Centers (QTCs) — the largest network for hemoglobinopathy gene therapies nationwide
  - **2026 outlook**: Doubling manufacturing capacity by mid-2026; targeting first full year of profitability; expanding LYFGENIA label to pediatric patients <12 years of age; advancing cryopreserved apheresis to improve the treatment experience

## Competitive Advantages
- **First-mover & market leader**: The only company with FDA approval for three gene therapies, and the market leader in the U.S. for hemoglobinopathy gene therapies
- **Proven commercial model**: >100 patients treated in a single year demonstrates real-world commercial execution and manufacturing scale
- **Decades of scientific innovation**: Over 30 years of R&D in genetic therapy, with extensive clinical data from hundreds of treated patients (including 15-year long-term follow-up studies)
- **Strong access**: LYFGENIA and ZYNTEGLO have meaningful access for >90% of eligible patients with commercial or Medicaid coverage
- **One-time curative approach**: Therapies are designed to treat the underlying cause of disease, offering durable, potentially life-long benefits from a single administration

## Strategic Focus
- **Commercial execution & patient access**: Expanding the Qualified Treatment Center network and making the treatment journey simpler for patients and providers
- **Manufacturing scale-up**: Doubling manufacturing capacity in 2026 through partnerships with CDMOs to meet growing patient demand
- **Process optimization**: Implementing cryopreserved apheresis to improve the patient and provider experience
- **Label expansion**: Advancing the HGB-210 Phase 3 study to bring LYFGENIA to pediatric sickle cell patients under 12 years of age
- **Full-year profitability**: Targeting the company's first full year of profitability in 2026

## Why Work Here
- **Mission-driven culture**: "United by purpose" — the company is laser-focused on transforming the lives of patients with rare, genetic diseases through curative therapies
- **Strong momentum**: Recently achieved first-ever profitable quarter, with rapid commercial growth and a clear plan for expansion in 2026
- **Remote/hybrid policy**: Roles are listed as both on-site (Somerville, MA) and remote (e.g., Account Manager, Gene Therapy) — flexible arrangements appear available depending on the role
- **Active hiring**: 23 job postings as of the search date, spanning Commercial, Quality Assurance, Technical Operations, Medical, and Regulatory functions
- **Experienced leadership**: Led by CEO David Meek (ex-Mirati Therapeutics, Ipsen) with a seasoned executive team of industry veterans, signaling strong strategic direction
- **Notable perks/culture**: High-impact work at the intersection of cutting-edge science and commercial execution; opportunity to join a company in the middle of a dramatic turnaround and growth phase; patient-centric focus with a dedicated support program

## Sources
1. [genetixbiotx.com - Company website](https://www.genetixbiotx.com/)
2. [job-boards.greenhouse.io - Careers page](http://job-boards.greenhouse.io/genetixbiotherapeutics)
3. [linkedin.com - LinkedIn company page](https://www.linkedin.com/company/genetix-biotherapeutics)
4. [genetixbiotx.com - Press release: Rebrand from bluebird bio](https://www.genetixbiotx.com/press-release-2025-09-18.html)
5. [genetixbiotx.com - Press release: 2025 commercial results & 2026 priorities](https://www.genetixbiotx.com/press-release-2026-03-02.html)

## Other roles at Genetix Biotherapeutics

- [Account Manager, Gene Therapy - Florida (South)](https://feeny.ai/job/account-manager-gene-therapy-florida-south-genetix-biotherapeutics-miami-hazzphbdxfpj) — Miami, FL
- [Account Manager, Gene Therapy - Texas](https://feeny.ai/job/account-manager-gene-therapy-texas-genetix-biotherapeutics-houston-kjrvreg2k43r) — Houston, TX
- [Account Manager, Gene Therapy - Great Lakes](https://feeny.ai/job/account-manager-gene-therapy-great-lakes-genetix-biotherapeutics-chicago-jb20r797dq6c) — Chicago, IL
- [Sr. Manager, LVV Manufacturing](https://feeny.ai/job/sr-manager-lvv-manufacturing-genetix-biotherapeutics-somerville-z0yp801tagkj) — Somerville, MA
- [National Account Executive, West](https://feeny.ai/job/national-account-executive-west-genetix-biotherapeutics-los-angeles-5j8hdvsqn5cg) — Los Angeles, CA
- [Director, Pricing, Payer Contracting & Analytics](https://feeny.ai/job/director-pricing-payer-contracting-analytics-genetix-biotherapeutics-somerville-qv5w015kka01) — Somerville, MA
- [Sr. Director, Quality Operations](https://feeny.ai/job/sr-director-quality-operations-genetix-biotherapeutics-somerville-traazwk35kj1) — Somerville, MA
- [Senior Manager, Quality Assurance Vendor & Audit Management](https://feeny.ai/job/senior-manager-quality-assurance-vendor-audit-management-genetix-sn50jbp7ge60) — Somerville, MA
- [Sr. Manager - IT Commercial and Medical Systems](https://feeny.ai/job/sr-manager-it-commercial-and-medical-systems-genetix-biotherapeutics-somerville-drs30kf4perv) — Somerville, MA
- [Sr. Director, Regulatory Strategy](https://feeny.ai/job/sr-director-regulatory-strategy-genetix-biotherapeutics-somerville-fpj4qjceza7s) — Somerville, MA