--- title: 'Sr Manager, Enterprise Business Systems at Iambic Therapeutics, Inc' canonical: 'https://feeny.ai/job/sr-manager-enterprise-business-systems-iambic-therapeutics-inc-san-diego-j2cv8nxyypq5' type: 'job' last_seen: '2026-11-11' --- # Sr Manager, Enterprise Business Systems at Iambic Therapeutics, Inc - **Company:** Iambic Therapeutics, Inc - **Location:** San Diego, CA - **Employment:** full-time - **Posted:** 2026-11-06 - **Last confirmed live:** 2026-11-11 - **Apply:** https://jobs.ashbyhq.com/iambic-therapeutics/94a82b39-cf0f-4543-b033-ae805af98761 ## Job description ## JOB SUMMARY We are seeking an experienced and results-driven Sr Manager, Enterprise Business Systems to join our growing IT team. This role will oversee the implementation, configuration, maintenance, and support of business-critical applications across the organization, with primary focus on the systems that run our General & Administrative (G&A) functions: Finance and Accounting, People/HR, Legal and Compliance, and Facilities, IT Operations, and Business Operations. The Sr. Manager, Enterprise Business Systems will collaborate with leaders across each G&A function to optimize workflows, troubleshoot system issues, and drive continuous improvement in business processes. This role ensures that business applications operate efficiently, securely, and meet the evolving strategic and tactical needs of the company. This position will be based out of our San Diego Headquarters. ## KEY RESPONSIBILITIES - Apply deep working knowledge of enterprise software across the G&A landscape to implement, integrate, and maintain business applications supporting: - Finance and Accounting (ERP, budget forecasting & tracking, procurement, invoicing & expenses), - People/HR (HRIS, payroll, talent acquisition, learning management) - Legal and Compliance (contract lifecycle management, e-signature, entity management) - Facilities/Operations (service management, asset and space management). - Ensure application security, role-based access controls, segregation of duties, and compliance with company policies across all G&A systems. - Perform regular system updates, patches, and upgrades to maintain performance and security. - Liaise with software vendors and service providers for application support and upgrades. - Integrate business applications with other systems and third-party tools and assist in data migrations, imports, and exports between systems. ## QUALIFICATIONS - Bachelor’s degree in Information Technology, Computer Science, Business Administration, or a related field. - 12 years IT experience, with 8+ years administering cross-functional business applications spanning multiple G&A functions, life sciences experience preferred - Experience supporting financial processing and audit controls for Sarbanes-Oxley compliance, as well as the access, confidentiality, and retention requirements of HR and Legal systems. - Working knowledge of data privacy and associated regulatory requirements such as GDPR, CCPA, HIPAA, and Transparency Reporting. - Strong experience implementing, maintaining and improving Finance, Procurement, HR, Legal and Compliance systems such as NetSuite, Adaptive, Procurify, HRIS, Ashby ATS, DocuSign, and Ironclad preferred - Experience managing SaaS vendor relationships, contracts, renewals, and license optimization across a portfolio of business applications. - Experience in system implementation, data migration, or process automation. - Excellent communication and collaboration abilities with strong analytical and problem-solving skills. - Prior experience with IT service management, identity and access management (SSO, SCIM, provisioning), and corporate IT or facilities systems preferred - Experience with reporting methodologies and business metrics preferred - Project management experience or certifications (e.g., PMP, ITIL, Agile) preferred ## ABOUT IAMBIC THERAPEUTICS Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. By utilizing molecular superintelligence — integrating proprietary AI with automated, scalable chemistry and biology experimentation — our platform is designed to address the totality of drug discovery and development. At Iambic, we are building an engine that is designed to power the future of medicine. Learn more at [iambic.ai](http://iambic.ai). ## MISSION & VALUES Our mission is to make better technology for better medicines. Three values guide how we work: - Bold. We are courageous, take thoughtful risks, and approach challenges with tenacity. - Innovative. We are creative and find new solutions that deliver impact. - Collaborative. We respect one another and partner with integrity. We value the range of perspectives our people bring, and we work to build an environment where every team member can contribute and grow. ## PAY AND BENEFITS The pay range for this role is listed above. Actual pay depends on factors including experience, skills, and location. Eligible employees in the U.S. receive company-paid medical coverage, flexible spending accounts, voluntary life insurance, 401(k) matching and flexible time off. We are in a brand-new state-of-the art facility in beautiful San Diego with a community gym, dining, and easy access to great places to live and play. ## EQUAL OPPORTUNITY Iambic is an equal opportunity employer. We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran or military status, or any other characteristic protected by law. ## About Iambic Therapeutics, Inc ## Company Overview - **One-liner**: Iambic Therapeutics is a clinical‑stage biotechnology company that uses an AI‑driven platform to discover and develop novel small‑molecule medicines for oncology and other diseases. - **Entity Type**: Private (late‑stage venture‑backed) - **Headquarters**: San Diego, California, United States - **Founded**: 2020 - **Founders**: Not explicitly named in available sources; leadership includes a Co‑Founder & CEO and a Co‑Founder & CTO. ## Core Business - **Primary industries**: Biotechnology, AI‑powered drug discovery, oncology therapeutics - **Target customers**: B2B partnerships with pharmaceutical companies (e.g., Bayer) and, ultimately, patients through a wholly‑owned pipeline of clinical‑stage candidates - **Mission**: *“Better technology for better medicines”* – using machine learning and automation to transform the creation of new therapeutics ## Products & Services - **Enchant Platform**: A multi‑modal transformer AI that breaks down data barriers between preclinical and clinical R&D, enabling rapid molecular design. - **NeuralPLexer**: A co‑folding AI technology that predicts protein‑ligand structures to guide drug design. - **Automated High‑Throughput Experimentation**: AI‑driven robotics that generate new biological data from novel molecular designs on a weekly cadence. - **IAM1363** (HER2 inhibitor): A highly selective, brain‑penetrant tyrosine kinase inhibitor for HER2‑driven cancers; currently in Phase 1b clinical studies. - **IAM‑C1** (CDK2/4 dual inhibitor): A potential first‑in‑class selective inhibitor for HR+/HER2‑ metastatic breast cancer (preclinical). - **IAM‑K1** (KIF18A inhibitor): A potential best‑in‑class allosteric inhibitor for triple‑negative breast cancer, ovarian cancer, and other solid tumors (preclinical). - **Undisclosed programs**: Additional wholly‑owned candidates across multiple target classes and mechanisms. ## Market Standing - **Valuation**: Not publicly disclosed - **Key Metric**: **Total funding** – $330.8 M (including a $100 M Series B in Oct 2023, a $50 M Series B extension in Apr 2024 led by EXOR N.V. and Mubadala Capital, and a $127.8 M venture round in Nov 2025) - **Notable Investors/Partners**: EXOR N.V., Mubadala Capital, Nexus Venture, Bayer (collaboration in AI drug discovery), and a Scientific Advisory Board including Nobel Laureate Frances Arnold (Caltech) - **Growth Signals**: - Headcount of **117** (64.5 % year‑over‑year growth) - Active job postings: **18** (+200 % quarterly, +50 % yearly) - Pipeline advanced from program launch to IND in **2 years** (vs. 6‑year industry average for IAM1363) - Broad platform applicability demonstrated across orthosteric, allosteric, and protein‑protein interaction modalities ## Competitive Advantages - **Speed**: AI‑driven platform can deliver development candidates to clinical trials in roughly one‑third the industry average time. - **Selectivity & Differentiated Profiles**: IAM1363 shows > 5000‑fold selectivity against EGFR, avoiding EGFR‑driven toxicity; IAM‑C1 targets CDK2/4 with a novel selectivity profile. - **Broad Platform Applicability**: Platform has produced leads across diverse protein classes and mechanisms (orthosteric, allosteric, PPI modulators). - **Integration of AI and Drug Hunting**: Tightly integrated team of AI experts and seasoned drug hunters, with a culture of “audacity” that tackles hard chemistry problems. ## Strategic Focus - Advancing the clinical pipeline: IAM1363 Phase 1b, preparing IAM‑C1 and IAM‑K1 for IND‑enabling studies. - Expanding platform partnerships (e.g., Bayer collaboration). - Scaling the organization: actively hiring in ML science, computational chemistry, medicinal chemistry, and clinical operations. - Exploring new therapeutic areas and target classes through the Enchant and NeuralPLexer technologies. ## Why Work Here - **Culture**: Values of **Respect**, **Collaboration**, and **Audacity** – cross‑functional teamwork with resilience and optimism; a flat, high‑trust environment. - **Work Model**: Based in La Jolla/San Diego, CA; the company emphasizes on‑site collaboration for drug‑discovery and lab‑based roles; remote/hybrid policy not explicitly stated. - **Team Growth**: Rapidly scaling (headcount +64 % YoY) with a strong pipeline of open roles in ML, computational chemistry, drug product development, and clinical operations. - **Cutting‑Edge Work**: Opportunity to work at the intersection of frontier AI (large multimodal models, agentic data pipelines) and real‑world drug discovery that reaches patients. - **Leadership & Mentorship**: Advisory board includes Nobel laureate and former NVIDIA AI director; close integration of AI and biology. ## Sources 1. [iambic.ai](https://www.iambic.ai/) – Homepage, platform, and corporate overview 2. [iambic.ai/about](https://www.iambic.ai/about) – Leadership, advisory board, investors 3. [iambic.ai/pipeline](https://www.iambic.ai/pipeline) – Pipeline details (IAM1363, IAM‑C1, IAM‑K1) 4. [iambic.ai/careers](https://www.iambic.ai/careers) – Careers page, values, open positions 5. [linkedin.com/company/iambic-ai](https://www.linkedin.com/company/iambic-ai) – Company stats (headcount 117, $3.4M revenue, $330.8M funding, funding rounds, employee growth) ## Other roles at Iambic Therapeutics, Inc - [Research Scientist II/Senior Research Scientist, Medicinal Chemistry](https://feeny.ai/job/research-scientist-ii-senior-research-scientist-medicinal-chemistry-iambic-0qhfd46bny8y) — San Diego, CA - [Associate Director/Director, FP&A](https://feeny.ai/job/associate-director-director-fp-a-iambic-therapeutics-inc-san-diego-z28z0y19xya6) — San Diego, CA - [Sr Manager, FP&A - Discovery R&D](https://feeny.ai/job/sr-manager-fp-a-discovery-r-d-iambic-therapeutics-inc-san-diego-sznt8xkbx741) — San Diego, CA - [Director, IP Counsel](https://feeny.ai/job/director-ip-counsel-iambic-therapeutics-inc-san-diego-492xa6xt2p79) — San Diego, CA - [Corporate Counsel, Commercial](https://feeny.ai/job/corporate-counsel-commercial-iambic-therapeutics-inc-san-diego-ww25hgtsp3t5) — San Diego, CA - [IT Support Specialist](https://feeny.ai/job/it-support-specialist-iambic-therapeutics-inc-san-diego-g98wd14jdssg) — San Diego, CA - [Sr Associate Scientist I or II, Medicinal Chemistry](https://feeny.ai/job/sr-associate-scientist-i-or-ii-medicinal-chemistry-iambic-therapeutics-inc-san-7zek78ek4h8y) — San Diego, CA - [Principal Scientist, Medicinal Chemistry](https://feeny.ai/job/principal-scientist-medicinal-chemistry-iambic-therapeutics-inc-san-diego-et7kjjyvc1yv) — San Diego, CA - [Principal / AD / Director, Agentic AI](https://feeny.ai/job/principal-ad-director-agentic-ai-iambic-therapeutics-inc-san-diego-1g1gksks4q51) — San Diego, CA - [Software Engineer I/II - Scientific Computing](https://feeny.ai/job/software-engineer-i-ii-scientific-computing-iambic-therapeutics-inc-boston-2vn970jxspag) — Boston, MA