--- title: 'Sr Manager, FP&A - Discovery R&D at Iambic Therapeutics, Inc' canonical: 'https://feeny.ai/job/sr-manager-fp-a-discovery-r-d-iambic-therapeutics-inc-san-diego-sznt8xkbx741' type: 'job' last_seen: '2026-09-09' --- # Sr Manager, FP&A - Discovery R&D at Iambic Therapeutics, Inc - **Company:** Iambic Therapeutics, Inc - **Location:** San Diego, CA - **Compensation:** $144k–$180k - **Employment:** full-time - **Work type:** hybrid - **Posted:** 2026-09-08 - **Last confirmed live:** 2026-09-09 - **Apply:** https://jobs.ashbyhq.com/iambic-therapeutics/77e13632-a60f-4cbb-8f7e-73a2f0f8c6df/application **Skills:** Financial Planning and Analysis (FP&A), Financial Modeling, Advanced Excel, ERP Systems, Financial Planning Tools, Biotech, Pharma, or Life Sciences Experience, Investment Banking Experience, Public Accounting Experience, Management Consulting Experience, NetSuite, Adaptive Planning, Anaplan > Senior Manager of FP&A partnering with Discovery R&D groups to lead financial planning, forecasting, and analytics for internal pipelines and external partnerships. Based in San Diego with remote flexibility for experienced candidates. ## Job description ## JOB SUMMARY We are hiring a Senior Manager – Discovery R&D to join the growing Finance Team at Iambic, an innovative biotech company redefining drug discovery and development by applying industry-leading AI and Machine Learning technology. Reporting to the Head of FP&A, this role will be responsible for partnering with our Discovery R&D groups on a broad range of planning and forecasting activities for Iambic’s internal pipeline and external partnership programs and providing them with detailed analytics and insights to help inform strategic decision-making. This position will be based in our San Diego Headquarters, with exceptions for experienced candidates to work remotely. ## RESPONSIBILITIES - Serve as primary finance business partner for all Discovery groups covering both internal pipeline and external partnership programs, including Computational Chemistry, Medicinal Chemistry, Biology, DMPK, Analytical, Toxicology, and HTE & Lab Operations. - Lead the financial planning process (annual planning cycle, mid-year reforecast and quarterly budget-to-actual meetings) for all Discovery groups. - Develop and maintain robust financial models and budgets to track all spending by group, program, and project, and detailed headcount plans. - Provide timely and actionable financial insights to senior leadership in support of strategic decision-making. - Assist in long-range planning efforts as well as scenario planning initiatives for our internal pipeline and external partnership programs. - Build comprehensive program budgets to support Business Development scaling efforts and ongoing negotiations. - Collaborate with the Accounting team on month-end close activities, including preclinical and other accruals. - Support the development of scalable, gold-standard FP&A tools, systems and processes as the company grows. - Work effectively as a team contributor on all assignments, as well as independently, while understanding the necessity for communicating and coordinating work efforts with colleagues across the organization. - Perform ad hoc analysis and special projects, as assigned. ## QUALIFICATIONS - Bachelor’s degree in Accounting, Finance, Economics, or a related discipline preferred. Equivalent work experience will be considered; MBA or CPA a plus. - 8 - 12 years of professional FP&A experience within biotech, pharma or life sciences. Prior experience in investment banking, public accounting, or management consulting is a plus. - Strong understanding of R&D life cycles, preclinical drug discovery and development processes, and associated cost drivers. - Advanced Excel and financial modeling skills; prior experience with enterprise resource planning (ERP) systems (e.g. NetSuite) and financial planning tools (e.g. Adaptive Planning, Anaplan, or similar) is preferred. - Strong communication and presentation skills required, with the ability to partner effectively across scientific and business teams. - Ability to prioritize, coordinate and handle multiple projects to meet deadlines. - Self-motivated and strong desire to build new processes and tools to support a growth-oriented organization. - Strong analytical mindset, attention to detail, and ability to thrive in a fast-paced, dynamic environment are required. ## ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai. ## MISSION & CORE VALUES Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies. ## PAY AND BENEFITS We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play. ## About Iambic Therapeutics, Inc ## Company Overview - **One-liner**: Iambic Therapeutics is a clinical‑stage biotechnology company that uses an AI‑driven platform to discover and develop novel small‑molecule medicines for oncology and other diseases. - **Entity Type**: Private (late‑stage venture‑backed) - **Headquarters**: San Diego, California, United States - **Founded**: 2020 - **Founders**: Not explicitly named in available sources; leadership includes a Co‑Founder & CEO and a Co‑Founder & CTO. ## Core Business - **Primary industries**: Biotechnology, AI‑powered drug discovery, oncology therapeutics - **Target customers**: B2B partnerships with pharmaceutical companies (e.g., Bayer) and, ultimately, patients through a wholly‑owned pipeline of clinical‑stage candidates - **Mission**: *“Better technology for better medicines”* – using machine learning and automation to transform the creation of new therapeutics ## Products & Services - **Enchant Platform**: A multi‑modal transformer AI that breaks down data barriers between preclinical and clinical R&D, enabling rapid molecular design. - **NeuralPLexer**: A co‑folding AI technology that predicts protein‑ligand structures to guide drug design. - **Automated High‑Throughput Experimentation**: AI‑driven robotics that generate new biological data from novel molecular designs on a weekly cadence. - **IAM1363** (HER2 inhibitor): A highly selective, brain‑penetrant tyrosine kinase inhibitor for HER2‑driven cancers; currently in Phase 1b clinical studies. - **IAM‑C1** (CDK2/4 dual inhibitor): A potential first‑in‑class selective inhibitor for HR+/HER2‑ metastatic breast cancer (preclinical). - **IAM‑K1** (KIF18A inhibitor): A potential best‑in‑class allosteric inhibitor for triple‑negative breast cancer, ovarian cancer, and other solid tumors (preclinical). - **Undisclosed programs**: Additional wholly‑owned candidates across multiple target classes and mechanisms. ## Market Standing - **Valuation**: Not publicly disclosed - **Key Metric**: **Total funding** – $330.8 M (including a $100 M Series B in Oct 2023, a $50 M Series B extension in Apr 2024 led by EXOR N.V. and Mubadala Capital, and a $127.8 M venture round in Nov 2025) - **Notable Investors/Partners**: EXOR N.V., Mubadala Capital, Nexus Venture, Bayer (collaboration in AI drug discovery), and a Scientific Advisory Board including Nobel Laureate Frances Arnold (Caltech) - **Growth Signals**: - Headcount of **117** (64.5 % year‑over‑year growth) - Active job postings: **18** (+200 % quarterly, +50 % yearly) - Pipeline advanced from program launch to IND in **2 years** (vs. 6‑year industry average for IAM1363) - Broad platform applicability demonstrated across orthosteric, allosteric, and protein‑protein interaction modalities ## Competitive Advantages - **Speed**: AI‑driven platform can deliver development candidates to clinical trials in roughly one‑third the industry average time. - **Selectivity & Differentiated Profiles**: IAM1363 shows > 5000‑fold selectivity against EGFR, avoiding EGFR‑driven toxicity; IAM‑C1 targets CDK2/4 with a novel selectivity profile. - **Broad Platform Applicability**: Platform has produced leads across diverse protein classes and mechanisms (orthosteric, allosteric, PPI modulators). - **Integration of AI and Drug Hunting**: Tightly integrated team of AI experts and seasoned drug hunters, with a culture of “audacity” that tackles hard chemistry problems. ## Strategic Focus - Advancing the clinical pipeline: IAM1363 Phase 1b, preparing IAM‑C1 and IAM‑K1 for IND‑enabling studies. - Expanding platform partnerships (e.g., Bayer collaboration). - Scaling the organization: actively hiring in ML science, computational chemistry, medicinal chemistry, and clinical operations. - Exploring new therapeutic areas and target classes through the Enchant and NeuralPLexer technologies. ## Why Work Here - **Culture**: Values of **Respect**, **Collaboration**, and **Audacity** – cross‑functional teamwork with resilience and optimism; a flat, high‑trust environment. - **Work Model**: Based in La Jolla/San Diego, CA; the company emphasizes on‑site collaboration for drug‑discovery and lab‑based roles; remote/hybrid policy not explicitly stated. - **Team Growth**: Rapidly scaling (headcount +64 % YoY) with a strong pipeline of open roles in ML, computational chemistry, drug product development, and clinical operations. - **Cutting‑Edge Work**: Opportunity to work at the intersection of frontier AI (large multimodal models, agentic data pipelines) and real‑world drug discovery that reaches patients. - **Leadership & Mentorship**: Advisory board includes Nobel laureate and former NVIDIA AI director; close integration of AI and biology. ## Sources 1. [iambic.ai](https://www.iambic.ai/) – Homepage, platform, and corporate overview 2. [iambic.ai/about](https://www.iambic.ai/about) – Leadership, advisory board, investors 3. [iambic.ai/pipeline](https://www.iambic.ai/pipeline) – Pipeline details (IAM1363, IAM‑C1, IAM‑K1) 4. [iambic.ai/careers](https://www.iambic.ai/careers) – Careers page, values, open positions 5. [linkedin.com/company/iambic-ai](https://www.linkedin.com/company/iambic-ai) – Company stats (headcount 117, $3.4M revenue, $330.8M funding, funding rounds, employee growth) ## Other roles at Iambic Therapeutics, Inc - [Director/Senior Director, Immunology](https://feeny.ai/job/director-senior-director-immunology-iambic-therapeutics-inc-san-diego-pc8aedpavc67) — San Diego, CA - [Software Engineer — Agentic data pipelines](https://feeny.ai/job/software-engineer-agentic-data-pipelines-iambic-therapeutics-inc-united-states-z1afztyyenvn) — United States - [Principal Medical Writer](https://feeny.ai/job/principal-medical-writer-iambic-therapeutics-inc-united-states-p7p8wv9kdmyd) — United States - [Sr Manager, Quality Systems & Compliance](https://feeny.ai/job/sr-manager-quality-systems-compliance-iambic-therapeutics-inc-united-states-vsh166q5vj7e) — United States - [Research Scientist I/II, Bioanalytical Sciences & Assay Development](https://feeny.ai/job/research-scientist-i-ii-bioanalytical-sciences-assay-development-iambic-z1xnw171hxqv) — San Diego, CA - [Machine Learning Scientist – Clinical Prediction](https://feeny.ai/job/machine-learning-scientist-clinical-prediction-iambic-therapeutics-inc-boston-r8b4amskssr5) — Boston, MA - [Machine Learning Scientist — Large Multimodal Models (Post-Training)](https://feeny.ai/job/machine-learning-scientist-large-multimodal-models-post-training-iambic-7rzbhfe24hz9) — United Kingdom - [Machine Learning Scientist — Large Multimodal Models (Post-Training)](https://feeny.ai/job/machine-learning-scientist-large-multimodal-models-post-training-iambic-tq20zrdrpft4) — Boston, MA - [Senior / Executive Director, Analytical Development CMC](https://feeny.ai/job/senior-executive-director-analytical-development-cmc-iambic-therapeutics-inc-xc2n3pav2s88) — United States - [Associate Director / Director, Clinical Pharmacology](https://feeny.ai/job/associate-director-director-clinical-pharmacology-iambic-therapeutics-inc-san-je8hv9zyhrrm) — San Diego, CA