---
title: 'Sr. R&D IT Manager at 4D Molecular Therapeutics'
canonical: 'https://feeny.ai/job/sr-r-d-it-manager-4d-molecular-therapeutics-emeryville-k0jgj2p6e3cj'
type: 'job'
last_seen: '2026-11-08'
---

# Sr. R&D IT Manager at 4D Molecular Therapeutics

- **Company:** 4D Molecular Therapeutics
- **Location:** Emeryville, CA
- **Work type:** remote
- **Posted:** 2026-11-06
- **Last confirmed live:** 2026-11-08
- **Apply:** https://4dmoleculartherapeutics.com/careers/?gh_jid=4751727005

## Job description

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF biologics (aflibercept and anti-VEGF-C) with a single intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration and the second indication is diabetic macular edema, which are both in Phase 3 development. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery.

We are taking genetic medicine to new heights and into new disease areas to overcome challenges not addressed by existing medicines. This incredible challenge drives our relentless and talented team. Our people are the essence of our inspiring, innovative and collaborative environment that encourages individual contributions and provides opportunities for career development. We seek the best in the industry who identify with our mission and our bold and innovative results-driven approach. Our Core Values drive the way we work together:

- Dare to Cure
- Break Boundaries
- Beyond Yourself
- Prepare & Execute Relentlessly

Join us in creating the future of genetic medicine.

## GENERAL SUMMARY

4D Molecular Therapeutics (4DMT) is a late-stage clinical gene therapy company advancing a potentially transformative pipeline toward its first Biologics License Application (BLA) and commercial launch. Reporting to the Sr. Director, IT Business Partner, R&D, the Sr. R&D IT Manager, provides hands-on technology leadership and serves as the IT System Owner for assigned GxP and business-critical applications and initiatives supporting 4DMT organizations, including R&D, Technical Operations, Clinical Science and Operations, Data Sciences and Biostatistics, Quality Assurance (QA), Quality Control (QC), Regulatory Affairs, Pharmacovigilance, Program Management, Facilities, and Medical Affairs.

The role is accountable for the technical ownership, implementation, administration, integration, operation, security, support, inspection readiness, and lifecycle of an assigned group of systems. The Sr. Manager partners with Business Process Owners, QA, IT Computer System Validation (CSV), IT infrastructure teams, vendors, and implementation partners to ensure systems are fit for intended use, appropriately validated, reliable, secure, and supportable.

This is a hands-on IT role requiring a balanced combination of technical knowledge, GxP system lifecycle experience, and project leadership. The Sr. Manager applies independent judgment to resolve complex system-level issues, leads interdependent technical and compliance workstreams, provides senior-level guidance for assigned applications, and supports the appropriate use of automation and approved AI technologies. The role operates within the strategy established by IT leadership.

## MAJOR DUTIES & RESPONSIBILITIES:

- Serve as the IT System Owner for an assigned group of GxP and business-critical applications, including laboratory systems such as LIMS, chromatography data systems, laboratory instrument software, and scientific data platforms, with accountability for technical health, regulatory readiness, operational performance, supportability, and lifecycle outcomes.
- Partner with Business Process Owners to understand intended use, business processes, operational priorities, and user needs, and translate them into technology requirements, solution options, and recommendations.
- Partner with Quality Assurance and IT Computer System Validation to determine GxP applicability, system risk, validation strategy, required controls, testing approach, and lifecycle documentation while maintaining appropriate role independence.
- Lead complex system implementations, upgrades, integrations, migrations, remediation activities, and technology-enabled process improvements from evaluation through validated deployment and operational transition. Manage scope, schedule, risks, dependencies, approved budgets, and cross-functional workstreams.
- Administer or oversee application configuration, user accounts, security roles, interfaces, reports, scheduled processes, reference data, and other technical components within the authorized IT scope.
- Understand and maintain appropriate documentation of application architecture, hosting models, integrations, data flows, technical dependencies, identity and access controls, backup and recovery, business continuity, and vendor support arrangements.
- Ensure appropriate controls are established and maintained for electronic records and signatures, access, audit trails, data integrity, integrations, data migration, backup and recovery, retention, archival, change management, and vendor oversight.
- Serve as the senior IT escalation point for complex application, validation, integration, performance, instrument-interface, data-integrity, and vendor-performance issues, leading root-cause analysis and sustainable resolution.
- Maintain inspection-ready technical, validation, operational, and lifecycle documentation, and support audits, regulatory inspections, supplier assessments, periodic reviews, deviations, CAPAs, and remediation activities for assigned systems.
- Lead and manage contractors, consultants, managed-service providers, and vendor resources supporting assigned systems and projects. Establish priorities, deliverables, acceptance criteria, service expectations, and escalation paths; review performance and work quality; and ensure outsourced deliverables meet applicable technical, security, validation, documentation, and GxP requirements.
- Develop and manage lifecycle roadmaps for assigned applications and recommend upgrades, replacements, integrations, support-model improvements, and retirement. Identify appropriate opportunities to use workflow automation, low-code platforms, data tools, scripting, Microsoft Copilot, and other approved AI technologies to improve business processes and system operations.
- Lead cross-functional teams and mentor colleagues and system stakeholders in IT System Owner practices, application governance, validation partnership, operational support, inspection readiness, and vendor oversight.
- Communicate system health, project status, risks, technical options, and investment needs to stakeholders, and escalate material portfolio, architecture, compliance, funding, security, and resource decisions to IT leadership
- Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time

## QUALIFICATIONS:

Education:

- Bachelor’s degree in Computer Science, Information Systems, Software Engineering, or a related technical discipline
- Advanced degree or relevant professional certification is preferred

Experience:

- 8+ years of progressive experience with a Bachelor’s degree or 6+ years with a Master’s degree, supporting, implementing, administering, validating, and managing business applications in a pharmaceutical, medical-device, or comparable regulated environment.
- Hands-on experience serving as the IT System Owner, application owner, system administrator, technical lead, product owner, or comparable role for multiple regulated or business-critical applications.
- Experience with the full lifecycle of GxP computerized systems, including requirements, implementation, validation, deployment, change control, operational support, periodic review, upgrades, and retirement.
- Demonstrated experience leading complex GxP technology initiatives involving multiple business, technical, quality, validation, security, integration, and vendor stakeholders.
- Experience collaborating with Business Process Owners, QA, CSV, IT infrastructure teams, vendors, and implementation partners, and making system-level risk and lifecycle recommendations.
- Experience with GxP systems and interfaces, IT QA, or Computer System Validation is strongly preferred.
- Demonstrated experience directing contractors, consultants, implementation partners, or managed-service resources, including setting priorities, reviewing deliverables, monitoring performance, resolving delivery issues, and ensuring technical quality and compliance.

Other Qualifications/Skills:

- Strong understanding of IT System Owner responsibilities and GxP computerized system controls, including 21 CFR Part 11, EU Annex 11, GAMP 5, ALCOA+ principles, and risk-based Computer Software Assurance practices.
- Ability to quickly understand application architecture, integrations, data flows, hosting models, security controls, technical dependencies, and support requirements.
- Ability to balance business needs, compliance requirements, technical risks, operational support, security, and cost when making system-level recommendations.
- Strong project leadership, technical problem-solving, vendor management, documentation, and stakeholder communication skills.
- Working knowledge of programming, scripting, databases, workflow automation, or low-code technology sufficient to evaluate solution designs, vendor approaches, and automated solutions is preferred.
- Experience using Microsoft Copilot or other approved artificial-intelligence tools to improve productivity, documentation, information management, or business processes is preferred.

Travel: N/A

Physical Requirements and Working Conditions:

- Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
- Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).

Base salary compensation range: $135,000 - $150,000

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

## About 4D Molecular Therapeutics

## Company Overview
- **One-liner**: 4D Molecular Therapeutics is a late-stage clinical biotechnology company inventing and developing customized genetic medicines using a proprietary vector evolution platform to treat large-market diseases.
- **Entity Type**: Public (NASDAQ: FDMT)
- **Headquarters**: Emeryville, California, United States
- **Founded**: 2013
- **Founders**: David Kirn, MD (Co-Founder, President, and CEO)

## Core Business
- **Primary industry**: Biotechnology / Genetic Medicine / Gene Therapy
- **Target customers**: B2B (partnerships with other biopharma companies) and B2C (patients with retinal and pulmonary diseases)
- **Mission or purpose statement**: "To unlock the full potential of genetic medicines for large market diseases" by harnessing directed evolution to invent customized and enhanced vectors for transformative products.

## Products & Services
- **4D-150**: A clinical-stage genetic medicine candidate for retinal vascular diseases (wet age-related macular degeneration and diabetic macular edema). It is designed as a single, routine, low-dose intravitreal injection that provides multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C). Currently in Phase 3 clinical trials (4FRONT-1 and 4FRONT-2) for wet AMD and Phase 1/2 for DME.
- **4D-710**: An investigational genetic medicine candidate for cystic fibrosis lung disease. It uses the A101 vector for aerosol delivery of a corrective CFTR transgene (CFTR∆R) and is designed for patients ineligible for or who have discontinued CFTR modulator therapy. Currently in Phase 1/2.
- **4D-175**: A preclinical candidate for geographic atrophy (a form of dry AMD) using the R100 vector to deliver a shortened form of human complement factor H (sCFH) to restore normal complement regulation.
- **4D-725**: A preclinical candidate for alpha-1 antitrypsin (A1AT) lung disease using the A101 vector for aerosol delivery.

## Market Standing
- **Valuation/Market Cap**: $756.4 million (as of latest data from LinkedIn)
- **Key Metric**: Annual Revenue of $85.2 million (as of latest data from LinkedIn)
- **Notable Investors/Partners**: The company is publicly traded (IPO in 2020). Key partnerships are sought for pipeline candidates like 4D-175 and 4D-725.
- **Growth Signals**: The company is a late-stage biotech with two Phase 3 trials (4FRONT-1 and 4FRONT-2) for its lead candidate 4D-150 in wet AMD, and a Phase 1/2 trial for 4D-710 in cystic fibrosis. The company has a presence in Ecuador, France, and India. LinkedIn followers grew 24.7% year-over-year.

## Competitive Advantages
- **Proprietary Vector Platform (Therapeutic Vector Evolution)**: The company uses directed evolution to create customized and proprietary AAV vectors (e.g., R100 for retina, A101 for lung) that are optimized for specific tissues and routes of administration, which is a significant differentiator from standard gene therapy approaches.
- **Large-Market Focus**: Unlike many gene therapy companies targeting ultra-rare diseases, 4DMT is focused on large-market indications (wet AMD, DME, cystic fibrosis) with high unmet need, offering a potentially massive commercial opportunity.
- **Durable, Single-Dose Therapies**: Their products are designed to provide multi-year efficacy from a single injection, which could dramatically reduce treatment burden for patients compared to current standard-of-care (e.g., frequent eye injections for wet AMD).

## Strategic Focus
- **Advancing Late-Stage Pipeline**: The primary focus is executing the Phase 3 programs for 4D-150 in wet AMD and progressing 4D-710 in cystic fibrosis.
- **Expanding Indications**: The company is exploring 4D-150 for diabetic macular edema (DME) and seeking partnerships to advance 4D-175 (geographic atrophy) and 4D-725 (A1AT deficiency).
- **Platform Expansion**: Continuing to leverage the Therapeutic Vector Evolution platform to develop new genetic medicines for other large-market diseases.

## Why Work Here
- **Mission-Driven Culture**: The company is deeply committed to "daring to cure" and unlocking the potential of genetic medicine for patients with devastating diseases. Core values include "Dare to Cure," "Break Boundaries," "Prepare & Execute Relentlessly," and "Beyond Yourself."
- **Innovative Science**: Employees work on cutting-edge science at the intersection of gene therapy, vector engineering, and clinical development, tackling some of the biggest challenges in medicine.
- **Collaborative Environment**: The company emphasizes teamwork, internal and external collaboration, and a culture that empowers innovation.
- **Location & Perks**: Based in Emeryville, CA (San Francisco Bay Area). The company offers a competitive benefits package and a dynamic, collaborative environment.
- **Diversity & Inclusion**: 4DMT champions diversity, equity, and inclusion through an employee-led initiative called "4Diversity," which partners with charitable organizations and focuses on social equity.
- **Work Authorization**: Candidates must be authorized to work in the U.S. The company does not sponsor new nonimmigrant visa status petitions but welcomes candidates who require transfers or extensions.

## Sources
1. [4dmoleculartherapeutics.com](https://4dmoleculartherapeutics.com/)
2. [4dmoleculartherapeutics.com - About](https://4dmoleculartherapeutics.com/about/)
3. [4dmoleculartherapeutics.com - Careers](https://4dmoleculartherapeutics.com/careers/)
4. [4dmoleculartherapeutics.com - Pipeline](https://4dmoleculartherapeutics.com/pipeline/)
5. [LinkedIn - 4D Molecular Therapeutics](https://www.linkedin.com/company/4d-molecular-therapeutics-llc)

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