--- title: 'Sr. Scientist, Antibody Engineering at Scholar Rock' canonical: 'https://feeny.ai/job/sr-scientist-antibody-engineering-scholar-rock-cambridge-rq38r35f25k6' type: 'job' last_seen: '2026-10-18' --- # Sr. Scientist, Antibody Engineering at Scholar Rock - **Company:** Scholar Rock - **Location:** Cambridge, MA - **Compensation:** $125k–$155k - **Employment:** full-time - **Work type:** onsite - **Posted:** 2026-10-05 - **Last confirmed live:** 2026-10-18 - **Apply:** https://jobs.lever.co/scholarrock/be0284dd-e7cf-43e5-9e58-9781fce14ed4 ## Job description Scholar Rock is delivering muscle-targeted breakthroughs to transform the treatment of spinal muscular atrophy (SMA) and other rare neuromuscular diseases where muscle atrophy remains a critical unmet need. As a global leader in myostatin biology, a field focused on proteins that regulate muscle mass, the biopharmaceutical company is named for the visual resemblance of a scholar rock to protein structures. Our commitment to unlock fundamentally different treatment approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. Scholar Rock works every day to create new possibilities for patients through its highly innovative anti-myostatin program, including opportunities in additional rare neuromuscular diseases. Learn more about our neuromuscular franchise at ScholarRock.com and follow @ScholarRock on X and on LinkedIn. Summary of Position: At Scholar Rock, we strive to develop best-in-class antibody-based therapeutics across multiple disease areas by leveraging our Antibody Engineering and Structural Biology expertise. Scholar Rock is seeking highly motivated, energetic and collaborative Senior Scientist to join the Antibody Discovery and Engineering group. The successful candidate will design and execute antibody discovery and optimization campaigns using phage display and yeast display technology, contribute to the development and application of display-based screening strategies, and advance high-quality leads through biochemical and biophysical characterization. Hands-on experience with phage display is required; experience with yeast display is preferred.  Experience in recombinant protein purification and characterization are highly desirable. Position Responsibilities - Design, execute, and troubleshoot antibody discovery campaigns using phage display, including library screening, selection strategy development, clone recovery, and sequence analysis. - Optimizing antibody leads with display-based technologies, including affinity maturation, specificity engineering, and developability-focused screening. - Express and purify recombinant antibodies, antibody fragments, antigens, and related proteins using appropriate chromatographic methods. - Characterize binding, specificity, affinity, stability, purity, and other biochemical or biophysical properties of antibody candidates. - Analyze and interpret experimental data, maintain clear records, and communicate results and recommendations to project teams. - Collaborate cross-functionally with protein sciences, structural biology, assay biology, and therapeutic-area teams to advance discovery programs. - Evaluate and implement new technologies, workflows, and automation opportunities that strengthen antibody discovery and optimization capabilities. - Provide scientific leadership for project workstreams and mentor junior colleagues as appropriate. Candidate Requirements - Ph.D. in biochemistry, molecular biology, protein engineering, biophysics, or a related life-science field with relevant industry or postdoctoral experience; or an M.S./B.S. with commensurate relevant experience. Level will be determined by qualifications and experience. - Hands on experience with antibody discovery and optimization using phage display is required, yeast display experience is highly preferred. - Working knowledge of antibody formats, library design or screening principles, molecular biology, and sequence-based clone assessment. - Experience with protein purification techniques such as affinity, ion-exchange, and size-exclusion chromatography. - Ability to characterize proteins and antibodies using biochemical and biophysical methods such as SPR, BLI, ELISA, and flow cytometry. - Strong experimental design, problem-solving, documentation, communication, and teamwork skills. - Experience in applying structural insights to antibody design and optimization is preferred. Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. ## About Scholar Rock ## Company Overview - **One-liner**: Scholar Rock is a biopharmaceutical company discovering and developing selective therapies targeting growth factors for serious diseases with high unmet need. - **Entity Type**: Public (NASDAQ: SRRK) - **Headquarters**: Cambridge, Massachusetts, United States - **Founded**: 2012 - **Founders**: Not publicly available ## Core Business - **Primary industry**: Biotechnology / Biopharmaceuticals - **Target customers**: Patients suffering from neuromuscular disorders, cancer, fibrotic diseases, and hematologic conditions; healthcare providers and payers - **Mission**: “Turning scientific discoveries into a pipeline of investigational therapies aimed at diseases where growth factors play a central role.” ## Products & Services - **Apitegromab (SRK-015)**: A selective anti‑latent myostatin antibody in Phase 3 for spinal muscular atrophy (SMA). BLA resubmission and U.S. launch anticipated in 2026. - **SRK‑181**: A selective anti‑latent TGFβ1 antibody for locally advanced or metastatic solid tumors (immuno‑oncology). - **SRK‑373**: A context‑dependent anti‑latent TGFβ1 antibody for multiple fibrotic indications. - **SRK‑256**: A selective anti‑RGMc/HJV antibody for hematology indications. - **Proprietary Platform**: Broad technology for generating monoclonal antibodies that selectively target latent forms of growth factors (TGFβ superfamily). ## Market Standing - **Valuation/Market Cap**: $2.8 B (as of search date, 2026‑09‑06) - **Key Metric**: Annual revenue $0 (pre‑commercial); IPO in 2018 - **Notable Investors/Partners**: Not publicly available - **Growth Signals**: Headcount grew 27.4% YoY to 278 employees; workforce across 7 countries; 20,522 LinkedIn followers (+45.9% yearly); first company to show clinical proof‑of‑concept for a muscle‑targeted treatment in SMA. ## Competitive Advantages - First‑in‑class platform for selectively targeting latent growth factors (TGFβ superfamily), enabling high specificity and reduced off‑target effects. - Proven clinical proof‑of‑concept in SMA with apitegromab, a novel mechanism. - Broad pipeline spanning neuromuscular, oncology, fibrosis, and hematology, with multiple programs in Phase 2/3. ## Strategic Focus - Advance apitegromab toward regulatory submission and commercial launch in SMA. - Expand pipeline into cardiometabolic disorders and other growth‑factor‑driven diseases. - Leverage platform to address historically under‑addressed disease areas. ## Why Work Here - **Culture**: “Passion for science” and “every voice counts” – a collaborative, trust‑based environment focused on changing patients’ lives. - **Work Policy**: Hybrid (e.g., Senior Director, Business Analytics in Cambridge, MA) and on‑site roles available. - **Benefits**: Competitive health/dental/vision plans, life/AD&D insurance, short‑ and long‑term disability, paid parental leave, 401(k) match, financial wellness program, professional development, free parking/transit pass, onsite fitness center, weekly community lunches, peer‑to‑peer recognition. - **Engineering/Science Culture**: Emphasis on innovation, cross‑functional teamwork, and direct impact on serious diseases. ## Sources 1. [scholarrock.com – Company Overview](https://scholarrock.com/our-company/careers/) 2. [scholarrock.com – Investors & Media](https://scholarrock.com/investors-media/) 3. [scholarrock.com – Pipeline](https://scholarrock.com/our-pipeline/) 4. [jobs.lever.co/scholarrock – Open Positions](https://jobs.lever.co/scholarrock) 5. [linkedin.com/company/scholar-rock – Company Profile](https://linkedin.com/company/scholar-rock) ## Other roles at Scholar Rock - [Director, External & CMC Quality Assurance](https://feeny.ai/job/director-external-cmc-quality-assurance-scholar-rock-cambridge-t2bkz2tbxrw6) — Cambridge, MA - [Director, International Indirect Tax](https://feeny.ai/job/director-international-indirect-tax-scholar-rock-dublin-yat476xmdnaz) — Dublin, Ireland - [Director, Domestic Tax](https://feeny.ai/job/director-domestic-tax-scholar-rock-cambridge-yssxb1zmhevd) — Cambridge, MA - [Senior Manager/Associate Director, Accounting EMEA](https://feeny.ai/job/senior-manager-associate-director-accounting-emea-scholar-rock-dublin-ykewdwpwypsq) — Dublin, Ireland - [Associate Director/ Director FP&A EMEA](https://feeny.ai/job/associate-director-director-fp-a-emea-scholar-rock-zug-7c5ns4k0785b) — Zug, Switzerland - [Office Manager and Executive Administrative Coordinator](https://feeny.ai/job/office-manager-and-executive-administrative-coordinator-scholar-rock-miami-tfarbzh553pn) — Miami, FL - [Associate Director, IT Service Delivery & Support](https://feeny.ai/job/associate-director-it-service-delivery-support-scholar-rock-cambridge-eap0qrr6kdn6) — Cambridge, MA - [Sr. Director, Infrastructure & Operations](https://feeny.ai/job/sr-director-infrastructure-operations-scholar-rock-cambridge-pxh15te0hg5s) — Cambridge, MA - [Sr. Director, Enterprise Business Applications](https://feeny.ai/job/sr-director-enterprise-business-applications-scholar-rock-cambridge-sppctggb090f) — Cambridge, MA - [Workplace Services Senior Manager](https://feeny.ai/job/workplace-services-senior-manager-scholar-rock-cambridge-qtzt3zrarycq) — Cambridge, MA