---
title: 'Sr. Scientist, Virus Construction at Replimune'
canonical: 'https://feeny.ai/job/sr-scientist-virus-construction-replimune-milton-park-4m0war5v5qwj'
type: 'job'
last_seen: '2026-10-28'
---

# Sr. Scientist, Virus Construction at Replimune

- **Company:** Replimune
- **Location:** Milton Park
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-10-28
- **Last confirmed live:** 2026-10-28
- **Apply:** https://jobs.ashbyhq.com/replimune/d6f49c00-d965-4753-9a2c-9e3ecf8f9f9c

## Job description

## Overview

Replimune’s mission is to revolutionize cancer treatment with therapies designed to activate a powerful and durable full-body anti-tumor response, boldly transforming cancer care because patient’s lives depend on it.

At Replimune, we live by our values:

United: We Collaborate for a Common Goal. Audacious: We Are Bold. Dedicated: We Give Our Full Commitment. Candid: We Are Honest With Each Other.

People are at the center of everything we do, and when it comes to our employees, we make it personal. With a deep sense of purpose, a strong and evolving culture, a competitive and forward-looking total rewards program, everyone at Replimune has a unique opportunity to impact on the lives of patients, caregivers and themselves.

Join us, as we reshape the future.

Summary of job description: The Senior Scientist, Virus Construction, plays a key role in managing the design, development and testing of novel HSV-derived oncolytic virus candidates. The Senior Scientist, Virus Construction will drive key projects and will use their knowledge and experience of molecular, cellular, computational or other technologies to introduce and develop new methods to further characterize oncolytic virus products. The Senior Scientist, Virus Construction will additionally support translational research, biodistribution, toxicity, sequencing or other studies when required, including performing data analysis using statistical techniques, final data preparation, presentation, and reporting. The Senior Scientist, Virus Construction, may also act as line manager for other members of the Virus Construction team. This position is based in our Milton Park location and typically has a 5-day on-site expectation.

## Key responsibilities

- Manage and execute the design and construction of new oncolytic virus candidates in accordance with regulatory guidelines and requirements.
- Manage and execute the testing of novel oncolytic viruses using previously established and novel methods to confirm successful construction.
- Drive introduction, evaluation and qualification of methods for virus characterization and oversee execution and transfer to other departments e.g. AD, PD, etc., where required.
- Produce and assess critical materials required by other departments e.g. cell banks, virus controls and other biological materials.
- Coordinate and execute the batch production and testing of non-GMP virus material for use in internal studies and external collaborations.
- Contribute technical input to regulatory submissions and information requests e.g. BLA, IND, IMPDs.
- Collaborate with other functions e.g. Translational Research to support external clinical and non-clinical studies e.g. efficacy, toxicology, biodistribution and shedding etc, where required, through provision of virus material, technical input and data analysis.
- Drive the daily operation of the Virus Construction department, ensuring laboratories are maintained and operations are completed in accordance with company policies and procedures, e.g. Health and Safety, Biological Safety, equipment, consumables management etc. Other responsibilities
- Provide subject matter expert input relating to biological safety of existing and novel oncolytic viruses and GMOs and other safety-related activities.
- Represent Virus Construction department in cross-functional projects with Analytical Development, Translational Research, Process Development, Quality Assurance, Regulatory Affairs and external partners.
- Provide direct line management, mentorship or training for other members of the Virus Construction department if required.
- Manage, author and review relevant technical reports, SOP’s, risk assessments and other documentation as required. Educational requirements
- B.A or [B.Sc](http://B.Sc). degree in a relevant biological science. M.S., Ph.D. or other postgraduate degree in biochemistry, virology or related science is preferred.

## Experience and skill requirements

- 6-8+ years industry experience, preferably in a Cell & Gene Therapy or virology-based environment encompassing product lifecycle from concept to commercialization.
- Significant experience in the molecular construction and characterisation of novel ATMP’s/gene therapies.
- Experience in molecular/cellular biological techniques including some of: molecular biology/cloning, cell culture, cell-based analytical methods, ELISA, PCR/qPCR, virus particle characterization, immunoblotting, whole-genome sequencing etc.
- Demonstrated project management, line management and time management skills and able to work independently, as part of a small team and cross functionally, with effective verbal and written communication.
- Independent data analysis capability using statistical methods and good IT skills in core applications e.g. Microsoft Word, Excel, Outlook etc.

## About Replimune

Replimune Group, Inc., headquartered in Woburn, MA, was founded in 2015 with the mission to transform cancer treatment by pioneering the development of a novel portfolio of oncolytic immunotherapies. Replimune’s proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. The RPx product candidates are expected to be synergistic with most established and experimental cancer treatment modalities, leading to the versatility to be developed alone or combined with a variety of other treatment options. For more information, please visit [www.replimune.com](http://www.replimune.com). We are an Equal Opportunity Employer.

## About Replimune

## Company Overview
- **One-liner**: Replimune is a clinical-stage biotech company focused on revolutionizing cancer treatment with a new class of oncolytic immunotherapies intended to activate a powerful and durable full-body anti-tumor response.
- **Entity Type**: Public (ticker not explicitly provided in search results, but company is publicly traded)
- **Headquarters**: Framingham, Massachusetts, USA (with additional locations in Woburn, MA and Oxfordshire, UK)
- **Founded**: 2015
- **Founders**: Robert Coffin, Ph.D. (Founder and Chief Scientist)

## Core Business
- **Primary industry**: Biotechnology – oncology, oncolytic immunotherapy
- **Target customers**: B2B (pharmaceutical partners) and ultimately patients through healthcare providers
- **Mission**: To ignite a systemic immune response to cancer and reshape the future of cancer care

## Products & Services
- **RPx Platform**: Proprietary, next-generation HSV-1-based oncolytic immunotherapy platform that powers all pipeline candidates.
- **RP1**: Investigational oncolytic immunotherapy for advanced melanoma (IGNYTE trial, PDUFA date April 10, 2026) and non-melanoma skin cancers; also being studied as monotherapy in organ transplant patients with skin cancer (ARTACUS trial).
- **RP2**: Investigational oncolytic immunotherapy for metastatic uveal melanoma (Phase 2/3 RP2-202 trial) and hepatocellular carcinoma (Phase 2 in combination with atezolizumab/bevacizumab).

## Market Standing
- **Valuation/Market Cap**: Not publicly available in provided sources
- **Key Metric**: Clinical-stage; no approved products yet. Key regulatory milestone: FDA action date for RP1 in advanced melanoma on April 10, 2026.
- **Notable Partners**: Bristol-Myers Squibb (supply of nivolumab), Roche (supply of atezolizumab and bevacizumab) – Replimune retains full commercial rights.
- **Growth Signals**: Completed enrollment in IGNYTE trial; confirmatory IGNYTE-3 trial underway; own 63,000 sq ft U.S. manufacturing facility in Woburn, MA enabling global commercial supply; broad pipeline across multiple solid tumor indications.

## Competitive Advantages
- **Strong IP position**: Wholly-owned, unencumbered RPx platform with broad patent protection.
- **In-house manufacturing**: Dedicated U.S. facility for commercial-scale production, reducing reliance on contract manufacturers.
- **First-mover potential**: Poised to be one of the first oncolytic immunotherapies to reach the market if RP1 gains FDA approval.
- **Full rights retained**: All partnership agreements allow Replimune to keep full commercial rights to its therapies.

## Strategic Focus
- Advancing RP1 toward FDA approval in advanced melanoma (April 2026 PDUFA date)
- Expanding pipeline into additional indications (uveal melanoma, hepatocellular carcinoma, non-melanoma skin cancers)
- Building out commercial infrastructure and manufacturing capabilities
- Exploring combination therapies with checkpoint inhibitors (nivolumab, atezolizumab)

## Why Work Here
- **Culture**: Cross-functional, collaborative, values-driven environment. Employee survey results show 92% proud to work at Replimune, 88% feel they make a positive difference, 78% would recommend the company.
- **Flexibility**: Hybrid and remote work options available depending on role; home office and mobile phone stipend provided.
- **Compensation**: New hire equity grants, generous annual bonus plans, retirement plans with substantial company match (100% vested from day one).
- **Benefits**: Medical, dental, and vision insurance 100% paid by the company.
- **Locations**: U.S. (Woburn, MA and Framingham, MA) and UK (Oxfordshire) – opportunities to work across both sites.

## Sources
1. [Replimune Homepage](https://www.replimune.com/)
2. [Replimune Careers](https://www.replimune.com/careers)
3. [Replimune About Us](https://www.replimune.com/about-us)
4. [Replimune Team](https://www.replimune.com/team)
5. [Replimune Pipeline](https://www.replimune.com/pipeline)

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