--- title: 'Staff R&D Engineer, Instruments - Pleasanton, CA at Calyxo' canonical: 'https://feeny.ai/job/staff-r-d-engineer-instruments-pleasanton-ca-calyxo-pleasanton-7e2ehsmt2g3x' type: 'job' last_seen: '2026-09-07' --- # Staff R&D Engineer, Instruments - Pleasanton, CA at Calyxo - **Company:** Calyxo - **Location:** Pleasanton, CA - **Posted:** 2026-08-27 - **Last confirmed live:** 2026-09-07 - **Apply:** https://job-boards.greenhouse.io/calyxo/jobs/5215722007?gh_jid=5215722007 ## Job description Calyxo, Inc. is a medical device company headquartered in Pleasanton, California, USA. The company was founded in 2016 to address the profound need for improved kidney stone treatment. Kidney stone disease is a common, painful condition that consumes vast amounts of healthcare resources each year. Our team is led by executives and investors with a proven track record of commercializing paradigm-shifting devices to meet unmet needs within urology. Are you ready to change the future of kidney stone treatment? We are seeking high achievers who want to be part of a dynamic team working in a fun, diverse atmosphere. Summary: The Instruments Engineering team is a highly energetic and actively growing team that is responsible for developing and ultimately driving Calyxo’s instruments and accessories through to launch. In this role, you will lead design and development activities for released and next-generation devices and accessories, ensuring seamless integration of mechanical systems with vision, sensors, and software, and catalyzing the advancement of an innovative, single-use kidney stone treatment device. You will be immersed in a highly collaborative and multidisciplinary team, teaming up with cross-functional partners in Manufacturing, Quality, Marketing, Clinical, and Regulatory to successfully drive these novel concepts through all phases of development to commercialization. In This Role, You Will: - Lead design and development activities of new single-use devices and accessories, serving as a technical lead for these activities, and a core team lead, when required. - Ensure design and development pathways maintain adherence to the design control process, working with cross-functional partners to enable manufacturability, reliability, and scalability. - Create prototypes, design fixturing, devise feasibility studies, and execute testing to draw meaningful conclusions and guide product development. - Effectively solve engineering problems through methodical root cause analysis and data-driven solution finding. - Define and lead qualification strategies for new designs or processes, working in partnership with other teams across the organization to gain alignment. - Meaningfully translate customer requirements into new or revised product requirements and engineering specifications. - Use SolidWorks to create well-defined models, assemblies, and engineering drawings. - Generate purposeful Intellectual Property (IP) and contribute to the overall IP portfolio. - Effectively communicate project progress, results, and risks to relevant stakeholders. - Develop test methods, create and execute protocols, and author associated reports and risk documentation. - Drive communication with suppliers to progress activities relevant to component or subassembly development. - Coordinate external testing activities such as sterilization, packaging, and biocompatibility testing, ensuring alignment with project goals and timelines. Who You Will Report To: - Director, Instruments Engineering Requirements: - Bachelor’s degree in Mechanical Engineering, Biomedical Engineering, or a related field and a minimum of 10 years of medical device experience, OR - Advanced degree in a related field and a minimum of 9 years of medical device experience. - Work location: Pleasanton, CA - Travel: less than 10% - Full time employment - Understanding of medical device regulations, including ISO 13485 and FDA 21 CFR Part 820. - Experience leading technical teams and providing mentorship to other engineers. - Proven track record of taking new designs from concept stage through to commercialization. - Proven ability to apply DFX principles to create designs that can scale. - Proven design capabilities in two or more of the following key areas: injection molding, electromechanical sub-systems, catheter construction, endoscope construction, fluidics. - Proficiency in SolidWorks and a strong understanding of design for manufacturability, tolerance stack analysis, and GD&T. - Proficiency in conducting structured design of experiments (DOEs) and using statistical methods to analyze data. - Strong collaboration and communication skills, with the ability to work effectively on cross-functional teams. - Strong problem-solving and analytical skills, with a hands-on approach to product development and testing. - Experience creating and running simulations (CFD, FEA) to inform product development. - Experience in product development within regulated industries and knowledge of sterilization and biocompatibility testing. - Compliance with relevant county, state, and Federal rules regarding vaccinations. What We Offer: At Calyxo, you will be part of a knowledgeable, high-achieving, experienced and fun team.  You will work in a diverse work environment with experienced, proven leaders and have an opportunity to shape our company culture.  You will experience constant learning and dynamic challenges to help you grow and be the best version of yourself. We also offer an attractive compensation package, which includes: - A competitive base salary range of $175,000 - $190,000 and variable incentive plan - Stock options – ownership and a stake in growing a mission-driven company - Employee benefits package that includes 401(k), healthcare insurance and paid vacation Calyxo is deeply committed to fostering an environment where diversity and inclusion are not only valued but also prioritized. We believe a diverse and inclusive community empowers us to act courageously, care deeply, and dream boldly to impact people in big ways. Diverse viewpoints bring diverse capabilities, which strengthen our focus and fuel our growth. Calyxo is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify their identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. Disclaimer: At Calyxo, we prioritize a transparent and structured interview process to ensure the best fit for both our candidates and our team. Please be aware of the following: - Structured Interview Process: Our hiring process includes multiple stages of interviews where you will have the opportunity to communicate directly with Calyxo employees. This ensures that you gain a comprehensive understanding of the role and our company culture. - Verification of Identity: We do not extend job offers without first meeting candidates, either virtually or in person. This step is crucial to maintain the integrity of our hiring process and to ensure mutual alignment. - Beware of Scams: Calyxo will never request sensitive personal information, such as your full name, address, phone number, or identification documents, via email or online forms before an official interview. Calyxo representatives will always contact you using an email format of firstname.lastname@calyxoinc.com. If you receive a request for information from any other domain, please contact us directly at info@calyxoinc.com to verify the legitimacy of the communication. We appreciate your interest in joining Calyxo and look forward to getting to know you through our official channels. ## About Calyxo ## Company Overview - **One-liner**: Calyxo is a medical device company developing and commercializing the CVAC System, a minimally invasive technology for kidney stone treatment using the SURE Procedure. - **Entity Type**: Private (Series F, $40M raised in April 2026) - **Headquarters**: Pleasanton, California, United States - **Founded**: 2016 - **Founders**: Jee Shin (Founder & Chief Business Officer) ## Core Business - Primary industry: Medical Equipment Manufacturing (Urology) - Target customers: B2B – hospitals, urology clinics, and healthcare systems; end-users are urologists and patients - Mission: To improve care for patients with kidney stones by providing a paradigm-shifting, minimally invasive treatment that achieves superior stone clearance ## Products & Services - **CVAC System**: The company’s flagship device, used exclusively for the SURE Procedure (Steerable Ureteroscopic Renal Evacuation). It combines laser lithotripsy, microjet irrigation, dynamic vacuum aspiration, and a stone collection canister to achieve complete stone clearance in a single procedure. The system is FDA-cleared and supported by randomized controlled trial data showing superior outcomes compared to standard ureteroscopy. ## Market Standing - **Valuation**: Not publicly disclosed - **Key Metric**: Total Funding of $137.2M across 6 rounds (latest: Series F $40M in April 2026); Annual Revenue of $3.4M (per LinkedIn) - **Notable Investors/Partners**: The Series F round included 5 investors (names not specified in search results); prior rounds involved at least 3 investors in Series D and 2 in Series C. The company’s leadership has a track record of successful exits (e.g., NeoTract acquired by Teleflex for $1.1B). - **Growth Signals**: Headcount grew 65.9% YoY to 263 employees; LinkedIn followers increased 40.3% yearly; active job postings rose 190.9% YoY; clinical data published in peer-reviewed journals and presented at major urology conferences (AUA 2025). ## Competitive Advantages - **Clinically Proven Superiority**: The ASPIRE Level 1 randomized controlled trial demonstrated that the SURE Procedure using CVAC System achieves significantly higher stone clearance rates than standard ureteroscopy. - **Proprietary Technology**: Integrated laser lithotripsy, microjet irrigation, and dynamic aspiration in a single system – a unique combination not offered by competitors. - **Experienced Leadership**: Executives and investors with a proven history of commercializing paradigm-shifting urology devices (e.g., UroLift System). - **Strong IP Portfolio**: Over 40 patents from the CEO alone, indicating a defensible moat. ## Strategic Focus - **Commercialization**: Scaling sales and clinical adoption across the U.S. with a growing field sales team and territory managers. - **Clinical Evidence Generation**: Continuing to publish real-world and pre-clinical data to reinforce clinical superiority and drive adoption. - **Product Development**: Iterating on the CVAC system (redesigned version cleared by FDA in March 2024) and expanding engineering capabilities (active hiring in R&D, instruments, imaging, and systems integration). - **Market Expansion**: Building out manufacturing capacity and hiring for operations, quality, and regulatory roles to support growth. ## Why Work Here - **Culture**: Core values of "F.I.T to WIN" – Find Joy, Integrity, Transparency, and Win as a Team. Emphasis on collaboration, accountability, and celebrating wins. - **Growth Opportunity**: Rapidly scaling company (65% headcount growth) with active hiring across engineering, sales, clinical, and operations – offering career advancement in a high-impact environment. - **Work Model**: Hybrid/remote options available for some roles (e.g., Clinical Specialist roles are remote, Accounting Manager is remote); most engineering and corporate roles are based in Pleasanton, CA. - **Perks & Recognition**: Team members come from top medtech companies (Medtronic, Boston Scientific, Intuitive, Teleflex) indicating a high-caliber peer group. The company is backed by experienced investors and has a clear path to commercialization. - **Engineering Culture**: Strong focus on innovation – multiple intern roles and senior engineering positions in R&D, systems integration, and software; opportunity to work on a life-changing medical device from concept to volume manufacturing. ## Sources 1. [calyxoinc.com](https://calyxoinc.com/) – Company overview, product description, SURE Procedure details 2. [linkedin.com/company/calyxo](https://www.linkedin.com/company/calyxo) – Employee count, revenue, funding, growth metrics, culture, and open roles 3. [job-boards.greenhouse.io/calyxo](http://job-boards.greenhouse.io/calyxo) – Current job openings and career page messaging 4. [calyxoinc.com/about-calyxo-inc/team/](https://calyxoinc.com/about-calyxo-inc/team/) – Leadership team, founder details, and bios 5. [biospace.com](https://www.biospace.com/) (referenced in LinkedIn news feed) – News on clinical data presentations and FDA clearance 6. [businesswire.com](https://www.businesswire.com/) (referenced in LinkedIn news feed) – ASPIRE outcomes publication and FDA clearance announcements ## Other roles at Calyxo - [North Central Regional Business Manager - Remote USA](https://feeny.ai/job/north-central-regional-business-manager-remote-usa-calyxo-united-states-a1cars5jgqg3) — United States - [Jacksonville, FL based Territory Sales Manager - Remote, USA](https://feeny.ai/job/jacksonville-fl-based-territory-sales-manager-remote-usa-calyxo-united-states-k271njnwkh1x) — United States - [Portland, OR based Clinical Specialist - Remote, USA](https://feeny.ai/job/portland-or-based-clinical-specialist-remote-usa-calyxo-united-states-sz7pyy2dh48b) — United States - [Shreveport, LA based Clinical Specialist - Remote, USA](https://feeny.ai/job/shreveport-la-based-clinical-specialist-remote-usa-calyxo-united-states-5d3ahys5w8sv) — United States - [West Palm Beach, FL, Ft. 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