---
title: 'Staff Site Reliability Engineer at Manifold AI'
canonical: 'https://feeny.ai/job/staff-site-reliability-engineer-manifold-ai-cambridge-hqn1zncxhmnr'
type: 'job'
last_seen: '2026-09-09'
---

# Staff Site Reliability Engineer at Manifold AI

- **Company:** Manifold AI
- **Location:** Cambridge, MA
- **Posted:** 2026-06-09
- **Last confirmed live:** 2026-09-09
- **Apply:** https://job-boards.greenhouse.io/manifoldai/jobs/7767743003

## Job description

## About Manifold

Manifold is the AI platform for life sciences, accelerating life-changing medicines to patients. Our products speed up workflows in areas from target identification and clinical development to market access and precision medicine in the clinic, while maintaining the governance life sciences requires. Global companies and premier research institutions use Manifold to operate faster and more effectively. Backed by leading investors including Reach Capital, TQ Ventures, Calibrate Ventures, SilverArc Capital, and Industry Ventures, Manifold serves tens of thousands of users across hundreds of organizations globally.

## About the Role

Manifold is looking for a Staff Site Reliability Engineer (SRE) to work at the intersection of AI, data infrastructure, and life sciences. In this high-impact role, you will help design, build, and operate the multi-account AWS infrastructure that acts as the foundation for Manifold’s platform.

As a Staff SRE, you'll work closely with Platform engineering and Professional Services teams to ensure Manifold’s internal and customer-facing infrastructure is secure, scalable, and observable. SREs are expected to be fluent across a wide-ranging tech stack, and comfortable working in a high-pressure, multi-threaded environment. They are also expected to balance a bias towards automation with more pragmatic approaches and have an intuitive understanding of the tradeoffs involved. The infrastructure you deploy and manage will play a key role in Manifold's success and help our customers bring life-changing medicines to patients faster.

## What You'll Do

- Design and maintain infrastructure as code solutions, thinking holistically about topology and component dependencies. You will have full responsibility for everything from Terraform plans to production observability.
- Automate customer infrastructure deployments, including multi-account provisioning, database setup, workflow orchestration, and application bootstrapping.
- Manage CI/CD pipelines, including build reliability, test stability, and deployment automation for Manifold services.
- Troubleshoot complex production issues across infrastructure, data, and application layers. Leverage LLM to the fullest extend to minimize toil and and manage date to date operations.
- Networking and security / compliance work required for highly regulated environments.

## What You’ll Bring

- 7+ years in infrastructure, DevOps, SRE, or platform engineering roles with increasing scope and autonomy. You are a leader / doer who can establish operational standards and drive technical direction while also staying hands-on.
- Deep, hands-on cloud (AWS, GCP, or Azure) experience, hands-on application development experience, and comfortable in troubleshooting application issues.
- Significant infrastructure-as-code (Terraform) experience. Strong CI/CD (Github Action) experience.
- Familiarity with identity systems (Okta, Auth0), containerized deployments (Docker, ECS, Packer) and networking tooling (Tailscale, WireGuard). Working knowledge of data platform services, such as Snowflake, Airflow, dbt, and PostgreSQL.
- Comfort managing complex, multi-account environments where customer isolation, security boundaries, and regulatory requirements add real constraints.
- You move fast, make sound calls with the information available, and reset quickly when things don't go as planned. And you have strong bias towards pragmatic, incremental process automation.
- You possess a track record of improving developer experience and reducing CI/CD friction.
- The ability to effectively and positively collaborate with platform engineer, professional services, and customer IT groups.
- You've built AI into how you work. You're curious about new tools, resourceful in applying them, and have concrete examples of how AI changed your output.
- You've done your homework on what it means to accelerate life sciences research and you can articulate why that mission matters to you.

## Why Manifold

- We offer the unique opportunity to work at the frontier of AI in life sciences, helping the world's leading research and clinical institutions adopt transformative technology.
- This is a high-autonomy, high-impact role where your work directly leads to positive customer outcomes that accelerate breakthrough science.
- You will gain exposure to a wide range of technical and business challenges across oncology, genomics, clinical data, and AI agent development.
- You will work with a collaborative team of engineers, scientists, and operators who are building something genuinely new and important.
- This is an opportunity to grow fast in a company that takes talent seriously. We offer strong compensation packages and excellent benefits.

Salary Range

The base salary range for this position is $160,000–$225,000 annually.

- Please note: Final offer amounts are determined by multiple factors, including prior experience and expertise, and may vary from the amount above. This range does not represent additional compensation benefits (such as equity, 401K match or medical, dental or vision insurance).

## About Manifold AI

## Company Overview
- **One-liner**: Manifold is the Enterprise Agent Platform for life sciences, accelerating life-changing medicines to patients by automating data preparation, analysis, and collaboration across regulated workflows.
- **Entity Type**: Private (Series B, Dec 2025)
- **Headquarters**: Newton, Massachusetts, United States
- **Founded**: 2016
- **Founders**: Vivek Mohta (President & Co-Founder), Demba Ba (Co-Founder & Principal Data Scientist)

## Core Business
- **Primary industry**: Enterprise AI platform for life sciences (pharma, biotech, clinical research)
- **Target customers**: B2B – global pharmaceutical companies, premier research institutions, and clinical organizations
- **Mission**: Accelerate life-changing medicines to patients, from early discovery to the clinic, by applying agentic AI to transform traditional processes [manifold.ai/about](https://www.manifold.ai/about)

## Products & Services
- **[Agent OS](https://www.manifold.ai/platform)**: The core platform that automates the 80% of work that clogs R&D – interprets scientific intent, prepares datasets, configures tools, and applies organizational context to turn questions into insights in minutes.
- **Data Ingestion & Preparation Agents**: Context-engineer datasets so downstream agents can work.
- **Analysis Agents**: Run biostatistics, survival analysis, and bioinformatics pipelines end-to-end.
- **Cohort & Query Agents**: Build and slice across billions of clinical and genomic records using plain language.
- **Configurable Specialist Agents**: Tailored to fit specific organizational workflows and roles.
- **Governance & Compliance Layer**: Unified governance layer with fine-grained access controls, encryption, HIPAA, SOC 2, GDPR, TX-RAMP, NIST SP 800-171, and BAA readiness. Deploys to your private cloud (AWS) – data never leaves your environment [manifold.ai](https://www.manifold.ai/).

## Market Standing
- **Valuation**: Not disclosed
- **Key Metrics**:
  - Annual Revenue: $5.0M–$25.0M (estimated) [linkedin.com/company/manifoldinc](https://www.linkedin.com/company/manifoldinc)
  - Total Funding: $40.5M across 4 rounds (Pre-Seed, Seed, Series A, Series B)
  - Employees: 77 (+38.9% YoY) [linkedin.com/company/manifoldinc](https://www.linkedin.com/company/manifoldinc)
- **Notable Investors/Partners**: Reach Capital (led Series B), TQ Ventures (led Series A), Calibrate Ventures, SilverArc Capital, Industry Ventures, TTCER Partners [linkedin.com/company/manifoldinc](https://www.linkedin.com/company/manifoldinc)
- **Growth Signals**: Serves tens of thousands of users across hundreds of organizations globally; reported up to 100x faster query turnaround (weeks → minutes) and production-ready deployments in weeks, not quarters [manifold.ai](https://www.manifold.ai/).

## Competitive Advantages
- **Life-sciences‑native compliance**: Built from day one for HIPAA, IRB, BAA, PHI handling, and SOC 2 – AI runs inside customer compliance requirements, not around them.
- **Bring‑Your‑Own‑Cloud deployment**: Platform deploys to the customer’s own AWS environment; data stays with the customer and is fully auditable.
- **Agent OS specialization**: Unlike general AI platforms, Manifold’s agents are purpose-built for clinical, genomic, and real‑world data workflows, covering everything from data ingestion to biostatistics and cohort identification.
- **Measured impact**: Demonstrated reductions in query turnaround from months to minutes, with specific customer case studies in multimodal oncology data and multi‑omics platforms [manifold.ai](https://www.manifold.ai/).

## Strategic Focus
- **Current priorities**: Deepening agent capabilities across the full life‑science value chain (target identification → clinical development → market access → precision medicine) while maintaining rigorous governance and expanding the partner ecosystem.
- **Direction for growth**: Scaling the platform to more global pharma companies and research consortia, and increasing automation of the 80% of R&D work that is currently manual [manifold.ai/platform](https://www.manifold.ai/platform).

## Why Work Here
- **Culture**: High‑autonomy, high‑impact environment where engineers, scientists, and operators collaborate to build something genuinely new and important. Described as a “high‑pressure, multi‑threaded” but mission‑driven team [greenhouse.io](https://job-boards.greenhouse.io/manifoldai/jobs/7767743003).
- **Remote/Hybrid/Office**: The Staff SRE role is based in Cambridge, MA; likely a hybrid presence (office in Newton/Cambridge area). Specific policy not publicly detailed.
- **Notable perks**: Strong compensation packages with base salary range for Staff SRE $160,000–$225,000, plus equity, 401k match, medical/dental/vision insurance. Opportunity to work at the frontier of AI in life sciences and directly accelerate breakthrough science [greenhouse.io](https://job-boards.greenhouse.io/manifoldai/jobs/7767743003).
- **Engineering culture**: Emphasis on infrastructure as code, AI‑augmented workflows, and solving complex problems in regulated environments. Engineers are expected to be hands‑on and comfortable with a wide‑ranging tech stack (AWS, Terraform, Snowflake, Airflow, dbt, PostgreSQL, etc.).
- **Growth**: Fast‑growing company (+38.9% YoY headcount) with significant ownership and exposure to oncology, genomics, clinical data, and AI agent development.

## Sources
1. [manifold.ai](https://www.manifold.ai/) – Company homepage, product features, and impact metrics
2. [manifold.ai/about](https://www.manifold.ai/about) – Mission and company background
3. [manifold.ai/platform](https://www.manifold.ai/platform) – Platform capabilities (Agent OS, Governance, Collaboration, Infrastructure)
4. [linkedin.com/company/manifoldinc](https://www.linkedin.com/company/manifoldinc) – Company details, funding rounds, employee count, and growth
5. [greenhouse.io](https://job-boards.greenhouse.io/manifoldai/jobs/7767743003) – Staff Site Reliability Engineer job posting (compensation, culture, tech stack)

## Other roles at Manifold AI

- [Staff Software Engineer | Core Platform](https://feeny.ai/job/staff-software-engineer-core-platform-manifold-ai-cambridge-syzp38dw43a1) — Cambridge, MA
- [Vice President, Sales](https://feeny.ai/job/vice-president-sales-manifold-ai-cambridge-7w1cnxvhbb37) — Cambridge, MA
- [Senior Forward Deployed Engineer](https://feeny.ai/job/senior-forward-deployed-engineer-manifold-ai-cambridge-qjzz6mdw5sry) — Cambridge, MA
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