---
title: 'Staff Software Engineer | Core Platform at Manifold AI'
canonical: 'https://feeny.ai/job/staff-software-engineer-core-platform-manifold-ai-cambridge-syzp38dw43a1'
type: 'job'
last_seen: '2026-09-09'
---

# Staff Software Engineer | Core Platform at Manifold AI

- **Company:** Manifold AI
- **Location:** Cambridge, MA
- **Posted:** 2026-09-08
- **Last confirmed live:** 2026-09-09
- **Apply:** https://job-boards.greenhouse.io/manifoldai/jobs/7989138003

## Job description

## About Manifold

Manifold is the AI platform for life sciences, accelerating life-changing medicines to patients. Our products speed up workflows in areas from target identification and clinical development to market access and precision medicine in the clinic, while maintaining the governance life sciences requires. Global companies and premier research institutions use Manifold to operate faster and more effectively. Backed by leading investors including Reach Capital, TQ Ventures, Calibrate Ventures, SilverArc Capital, and Industry Ventures, Manifold serves tens of thousands of users across hundreds of organizations globally.

## About the Role

Manifold is looking for a Staff Software Engineer to join the Core Platform team: A small, senior group responsible for the foundational services that power Manifold's data, compute, and workflow capabilities.

As a Staff Engineer on the Core team you’ll have an opportunity to work on compute infrastructure, workflow orchestration, data pipelines, platform APIs and MCP services. You will be supporting active enterprise users (and their AI agents) who are analyzing genomics and life sciences datasets at scale. This is a hands-on, individual contributor role. But we’re also looking for individuals who demonstrate a strong sense of ownership and are experienced enough to help shape our longer term product architecture. These core services play a critical role in Manifold's success, and help our customers bring life-changing medicines to patients faster.

## What You'll Do

- Help design, build and operate Manifold’s compute and workflow orchestration services. Develop extensible and durable solutions for AMI management, autoscaling, custom runtime environments, 3rd party tool support, etc.
- Work closely with SRE team to Improve reliability and observability of Manifold core services. Establish operational standards, alerting, and run-books that move the team from reactive firefighting to proactive ownership.
- Be a technical multiplier. Mentor engineers, drive technical decisions through clearly written artifacts, and bring a cross-cutting perspective that improves the team's collective output.
- Partner with Product, Forward Deployed Engineers, and account teams to translate bespoke enterprise requirements into durable platform capabilities. Fully understand customers’ most pressing problems and validate end-to-end solutions.
- Contribute to Manifold’s AI-native platform vision. Spot AI industry trends before they happen, and have informed opinions about how they potentially benefit life sciences research.

## What You'll Bring

- 8+ years of enterprise software experience, with a meaningful portion spent on backend, infrastructure-adjacent, or distributed systems work. You've owned complex, scalable, production systems and can share plenty of real-world stories.
- Mastery of Python and deep infrastructure-as-code (Terraform) experience.
- Experience managing compute environments on AWS (EC2, ECS, Batch, or equivalent) including autoscaling and cost / performance tradeoffs.
- Bioinformatics workflow experience a plus (specifically WDL, Nextflow, or Cromwell).
- General Life sciences or other regulated-industry experience also a plus.
- Comfortable supporting a broad technical surface area. You know how to orient quickly in an unfamiliar codebase or system.
- Operational ownership mindset. You care about what happens in production, you build for observability from the start, and you close the loop on incidents with durable fixes.
- You've genuinely integrated AI tools into your engineering workflow and have concrete examples of how that changed your output. You're not just curious about this space, you're building in it.
- You've done your homework on what it means to accelerate life sciences research and you can articulate why that mission matters to you.

## Why Manifold

- We offer the unique opportunity to work at the frontier of AI in life sciences, helping the world's leading research and clinical institutions adopt transformative technology.
- This is a high-autonomy, high-impact role where your work directly leads to positive customer outcomes that accelerate breakthrough science.
- You will gain exposure to a wide range of technical and business challenges across oncology, genomics, clinical data, and AI agent development.
- You will work with a collaborative team of engineers, scientists, and operators who are building something genuinely new and important.
- This is an opportunity to grow fast in a company that takes talent seriously. We offer strong compensation packages and excellent benefits.

Salary Range

The base salary range for this position is $170,000–$220,000 annually.

- Please note: Final offer amounts are determined by multiple factors, including prior experience and expertise, and may vary from the amount above. This range does not represent additional compensation benefits (such as equity, 401K match or medical, dental or vision insurance).

## About Manifold AI

## Company Overview
- **One-liner**: Manifold is the Enterprise Agent Platform for life sciences, accelerating life-changing medicines to patients by automating data preparation, analysis, and collaboration across regulated workflows.
- **Entity Type**: Private (Series B, Dec 2025)
- **Headquarters**: Newton, Massachusetts, United States
- **Founded**: 2016
- **Founders**: Vivek Mohta (President & Co-Founder), Demba Ba (Co-Founder & Principal Data Scientist)

## Core Business
- **Primary industry**: Enterprise AI platform for life sciences (pharma, biotech, clinical research)
- **Target customers**: B2B – global pharmaceutical companies, premier research institutions, and clinical organizations
- **Mission**: Accelerate life-changing medicines to patients, from early discovery to the clinic, by applying agentic AI to transform traditional processes [manifold.ai/about](https://www.manifold.ai/about)

## Products & Services
- **[Agent OS](https://www.manifold.ai/platform)**: The core platform that automates the 80% of work that clogs R&D – interprets scientific intent, prepares datasets, configures tools, and applies organizational context to turn questions into insights in minutes.
- **Data Ingestion & Preparation Agents**: Context-engineer datasets so downstream agents can work.
- **Analysis Agents**: Run biostatistics, survival analysis, and bioinformatics pipelines end-to-end.
- **Cohort & Query Agents**: Build and slice across billions of clinical and genomic records using plain language.
- **Configurable Specialist Agents**: Tailored to fit specific organizational workflows and roles.
- **Governance & Compliance Layer**: Unified governance layer with fine-grained access controls, encryption, HIPAA, SOC 2, GDPR, TX-RAMP, NIST SP 800-171, and BAA readiness. Deploys to your private cloud (AWS) – data never leaves your environment [manifold.ai](https://www.manifold.ai/).

## Market Standing
- **Valuation**: Not disclosed
- **Key Metrics**:
  - Annual Revenue: $5.0M–$25.0M (estimated) [linkedin.com/company/manifoldinc](https://www.linkedin.com/company/manifoldinc)
  - Total Funding: $40.5M across 4 rounds (Pre-Seed, Seed, Series A, Series B)
  - Employees: 77 (+38.9% YoY) [linkedin.com/company/manifoldinc](https://www.linkedin.com/company/manifoldinc)
- **Notable Investors/Partners**: Reach Capital (led Series B), TQ Ventures (led Series A), Calibrate Ventures, SilverArc Capital, Industry Ventures, TTCER Partners [linkedin.com/company/manifoldinc](https://www.linkedin.com/company/manifoldinc)
- **Growth Signals**: Serves tens of thousands of users across hundreds of organizations globally; reported up to 100x faster query turnaround (weeks → minutes) and production-ready deployments in weeks, not quarters [manifold.ai](https://www.manifold.ai/).

## Competitive Advantages
- **Life-sciences‑native compliance**: Built from day one for HIPAA, IRB, BAA, PHI handling, and SOC 2 – AI runs inside customer compliance requirements, not around them.
- **Bring‑Your‑Own‑Cloud deployment**: Platform deploys to the customer’s own AWS environment; data stays with the customer and is fully auditable.
- **Agent OS specialization**: Unlike general AI platforms, Manifold’s agents are purpose-built for clinical, genomic, and real‑world data workflows, covering everything from data ingestion to biostatistics and cohort identification.
- **Measured impact**: Demonstrated reductions in query turnaround from months to minutes, with specific customer case studies in multimodal oncology data and multi‑omics platforms [manifold.ai](https://www.manifold.ai/).

## Strategic Focus
- **Current priorities**: Deepening agent capabilities across the full life‑science value chain (target identification → clinical development → market access → precision medicine) while maintaining rigorous governance and expanding the partner ecosystem.
- **Direction for growth**: Scaling the platform to more global pharma companies and research consortia, and increasing automation of the 80% of R&D work that is currently manual [manifold.ai/platform](https://www.manifold.ai/platform).

## Why Work Here
- **Culture**: High‑autonomy, high‑impact environment where engineers, scientists, and operators collaborate to build something genuinely new and important. Described as a “high‑pressure, multi‑threaded” but mission‑driven team [greenhouse.io](https://job-boards.greenhouse.io/manifoldai/jobs/7767743003).
- **Remote/Hybrid/Office**: The Staff SRE role is based in Cambridge, MA; likely a hybrid presence (office in Newton/Cambridge area). Specific policy not publicly detailed.
- **Notable perks**: Strong compensation packages with base salary range for Staff SRE $160,000–$225,000, plus equity, 401k match, medical/dental/vision insurance. Opportunity to work at the frontier of AI in life sciences and directly accelerate breakthrough science [greenhouse.io](https://job-boards.greenhouse.io/manifoldai/jobs/7767743003).
- **Engineering culture**: Emphasis on infrastructure as code, AI‑augmented workflows, and solving complex problems in regulated environments. Engineers are expected to be hands‑on and comfortable with a wide‑ranging tech stack (AWS, Terraform, Snowflake, Airflow, dbt, PostgreSQL, etc.).
- **Growth**: Fast‑growing company (+38.9% YoY headcount) with significant ownership and exposure to oncology, genomics, clinical data, and AI agent development.

## Sources
1. [manifold.ai](https://www.manifold.ai/) – Company homepage, product features, and impact metrics
2. [manifold.ai/about](https://www.manifold.ai/about) – Mission and company background
3. [manifold.ai/platform](https://www.manifold.ai/platform) – Platform capabilities (Agent OS, Governance, Collaboration, Infrastructure)
4. [linkedin.com/company/manifoldinc](https://www.linkedin.com/company/manifoldinc) – Company details, funding rounds, employee count, and growth
5. [greenhouse.io](https://job-boards.greenhouse.io/manifoldai/jobs/7767743003) – Staff Site Reliability Engineer job posting (compensation, culture, tech stack)

## Other roles at Manifold AI

- [Vice President, Sales](https://feeny.ai/job/vice-president-sales-manifold-ai-cambridge-7w1cnxvhbb37) — Cambridge, MA
- [Senior Forward Deployed Engineer](https://feeny.ai/job/senior-forward-deployed-engineer-manifold-ai-cambridge-qjzz6mdw5sry) — Cambridge, MA
- [Staff Site Reliability Engineer](https://feeny.ai/job/staff-site-reliability-engineer-manifold-ai-cambridge-hqn1zncxhmnr) — Cambridge, MA