--- title: 'Staff Software Engineer at Freenome' canonical: 'https://feeny.ai/job/staff-software-engineer-freenome-remote-68wakx1nw87x' type: 'job' last_seen: '2026-11-09' --- # Staff Software Engineer at Freenome - **Company:** Freenome - **Location:** Remote - **Work type:** remote - **Posted:** 2026-11-05 - **Last confirmed live:** 2026-11-09 - **Apply:** https://job-boards.greenhouse.io/freenome/jobs/8920288002 ## Job description About this opportunity: At Freenome, we are seeking a Staff Software Engineer to grow our Platform team and lead the development of our Real World Evidence engine. Join a stellar group of engineers on a mission to save lives with early cancer detection, at an exciting phase as we develop and commercialize new blood test products. The ideal candidate is an experienced lead software engineer with a strong background in developing scalable and reliable distributed software systems,  and integrating internal products with third-party solutions. In this role you will partner with a cross-functional team including product managers, clinical data analysts, informaticists, researchers, and external vendors. Your work will help these teams turn fragmented data into reliable, traceable datasets that support evidence generation and inform future product development. This role reports to our Director of Engineering, Platform. This is a remote position within the US, with occasional travel to our headquarters in Brisbane, CA, 2-3 times a year. What you’ll do: - Lead the design, development and operation of maintainable, scalable, and reliable backend software. - Build system and data integrations connecting data from commercial products and external providers with our analytical platforms, to enable a feedback loop that accelerates research and product development. - Work closely with TPMs and SMEs to understand business needs and translate product requirements into technical strategy and incremental execution. - Partner with the Real World Data team to evolve their tech stack, identify workflow bottlenecks, and build reusable tools for data curation and analysis. - Effectively use AI tools to scale engineering and RWD workflows, automating manual operations, reducing data curation efforts, and improving data quality. - Evaluate technologies, frameworks, and data providers through focused proofs of concept. - Lead code and design reviews, champion engineering best practices, and promote a culture of quality and collaboration. - Contribute to hiring and mentoring new team members, fostering their growth, and enhancing the team's technical knowledge and productivity. Must haves: - Bachelor of Science in Computer Science, Engineering, or related field or equivalent work experience. - 10+ years as a software engineer successfully shipping software in production preferably in backend or platform teams, and with 2+ years as lead developer. - Proficiency in Python and SQL. - Ability to build and operate distributed systems using Infrastructure as Code on public cloud platforms, preferably Azure or Google Cloud. - Expertise developing and running containerized software, preferably using Docker and Kubernetes. - A track record of building and operating data pipelines and integrations, with experience in areas including ingestion, database replication, analytical data modeling, or     data quality validation. - Experience building systems that process and store sensitive data, such as PHI, implementing access controls, audit logging, and secure data handling. - Software architecture leadership: you ship clean code, write clear design docs and ADRs, guide constructive reviews and collaborative technical decisions. - Excellent written and verbal communication skills, with a mindful and transparent approach to collaboration. - Ability to thrive in an environment where cross-functional collaboration, communication, and compromise are part of your day-to-day work. Nice to haves: - Domain-specific experience or academic background in life sciences, real world data, or related fields. - Working in an FDA-regulated environment, with a strong understanding of compliance requirements and best practices. - Columnar processing and storage using Apache Parquet. - Open lakehouse technologies and modern table formats such as Apache Iceberg. - Workflow orchestration frameworks like Flyte, Airflow, or similar. - Scientific Python frameworks and data-science tools. Benefits and additional information: The US target range of our base salary for new hires is $188,275 - $270,375. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.  Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ [freenome.com/job-openings/](http://freenome.com/job-openings/) for additional company information. Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Applicants have rights under Federal Employment Laws. - https://www.dol.gov/agencies/whd/posters/fmla - https://www.dol.gov/agencies/ofccp/posters - https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act California applicants please review the CCPA Notice at Collection here: - https://www.freenome.com/ccpa-privacy-notice-for-freenome-california-job-applicants/ #LI- Remote ## About Freenome ## Company Overview - **One-liner**: Freenome is a biotechnology company developing blood-based multi-omics tests powered by machine learning to detect cancer in its earliest, most treatable stages. - **Entity Type**: Private (Late Stage) – raised over $2B in total funding; stock symbol FRNM (NASDAQ) is associated with a related SPAC entity but the operating company remains privately held [linkedin.com] - **Headquarters**: Brisbane, California, United States - **Founded**: 2014 - **Founders**: Riley Ennis (Co-Founder and Chief Product Officer) and others [freenome.com] ## Core Business - **Primary industry**: Biotechnology / Early Cancer Detection - **Target customers**: B2B (health systems, insurers, employers) and B2C (patients via healthcare providers) - **Mission**: To create tools that empower everyone to prevent, detect, and treat their disease, starting with early cancer detection. ## Products & Services - **Freenome Multi-Omics Blood Test (Colorectal Cancer)**: A next-generation blood test that uses a multi-omics platform (cell-free DNA, methylation, proteins, etc.) combined with machine learning to detect early-stage colorectal cancer and advanced adenomas. Type: Diagnostic test (IVD) – currently under clinical validation and regulatory review [freenome.com]. ## Market Standing - **Valuation / Market Cap**: Not publicly disclosed (private). Total funding of $2.07B (LinkedIn estimate) or $1.428B (CB Insights); conflicting reports reflect different counting methods [linkedin.com], [cbinsights.com] - **Key Metric (Funding)**: Most recent round – $75M corporate round (Nov 2025) led by Roche, plus $254M venture round (Feb 2024) also led by Roche [linkedin.com] - **Notable Investors**: Perceptive Advisors, RA Capital Management, Roche Venture Fund, Kaiser Permanente, Novartis, American Cancer Society’s BrightEdge Ventures, Exact Sciences [linkedin.com], [freenome.com] - **Growth Signals**: - Blood-based test included in updated American Cancer Society colorectal cancer screening guideline - Appointed industry veteran Rob Guigley as Chief Commercial Officer (2025) - Ongoing clinical programs for multiple cancer types - Employee headcount of 304 with 22 active job postings (as of mid-2025) [linkedin.com] ## Competitive Advantages - **Multi-omics + AI platform**: Combines multiple biological signals (DNA methylation, fragmentomics, proteins) with proprietary machine learning algorithms to achieve high sensitivity and specificity for early-stage cancer. - **Strong clinical program**: Rigorous multi-site studies and partnerships with leading health systems (e.g., Kaiser Permanente). - **Deep investor backing**: Long-term support from top healthcare investors and strategic partners (Roche, Exact Sciences) provides capital and commercial pathways. - **First-mover in multi-cancer blood screening**: Focus on colorectal cancer as first indication, with potential to expand to other cancers. ## Strategic Focus - **Clinical validation & regulatory approval**: Completing pivotal studies and preparing FDA submission for colorectal cancer test. - **Commercial launch preparation**: Building commercial team (hiring Strategic Account Executives, VP Revenue Cycle Management) and establishing relationships with payers and health systems. - **Platform expansion**: Extending multi-omics technology to additional cancer types (lung, pancreatic, etc.) through research programs. ## Why Work Here - **Mission-driven culture**: Employees are motivated by the opportunity to “outpace cancer” and make a tangible impact on patient lives. Values include integrity, empathy, trust, servant leadership, and striving for greatness [freenome.com]. - **Equity ownership**: Every U.S. full-time employee receives equity packages, aligning personal success with company milestones [freenome.com/careers]. - **Competitive benefits**: Comprehensive medical plans, wellness programs, generous PTO, 12 paid holidays, annual bonus opportunities, and market-based salaries [freenome.com/careers]. - **Collaborative environment**: Cross-functional teams across clinical, scientific, and business domains; emphasis on respect and inclusion [freenome.com/careers]. - **Work model**: Likely office-based in Brisbane, CA (hybrid flexibility not explicitly stated). The company has a physical lab and office presence. - **Engineering & science culture**: Opportunity to work with state-of-the-art multi-omics data, machine learning, and clinical trial design. The team includes senior ML scientists, computational biologists, and software engineers. ## Sources 1. [freenome.com](https://www.freenome.com/) – Company overview, leadership, values, products 2. [freenome.com/careers](https://www.freenome.com/careers/) – Benefits, culture, job openings 3. [linkedin.com/company/freenome](https://www.linkedin.com/company/freenome) – Employee count, revenue estimate, funding rounds, investor list, recent hires and departures 4. [cbinsights.com/company/freenome](https://www.cbinsights.com/company/freenome) – Funding total, company description, patent activity ## Other roles at Freenome - [Computational Biologist](https://feeny.ai/job/computational-biologist-freenome-remote-cgja26st5bqf) - [Senior Staff Software Engineer](https://feeny.ai/job/senior-staff-software-engineer-freenome-remote-967fagps50tx) - [Senior Manager, Total Rewards](https://feeny.ai/job/senior-manager-total-rewards-freenome-brisbane-xzsxfrbn4zna) — Brisbane, CA - [Senior Systems Integration Engineer](https://feeny.ai/job/senior-systems-integration-engineer-freenome-brisbane-685r3d1r8b6w) — Brisbane, CA - [Senior Software Engineer, Site Reliability](https://feeny.ai/job/senior-software-engineer-site-reliability-freenome-remote-wmcdmqnnq13n) - [Postmarket Quality Manager](https://feeny.ai/job/postmarket-quality-manager-freenome-brisbane-tf35b1srzbq0) — Brisbane, CA - [Staff Technical Operations Scientist](https://feeny.ai/job/staff-technical-operations-scientist-freenome-brisbane-5xdj1a8tctn9) — Brisbane, CA - [Quality Control Specialist I (Contractor)](https://feeny.ai/job/quality-control-specialist-i-contractor-freenome-brisbane-mc4bcf1nyhjs) — Brisbane, CA - [Quality Control Specialist II (Contractor)](https://feeny.ai/job/quality-control-specialist-ii-contractor-freenome-brisbane-94f4tb6dq8g8) — Brisbane, CA - [Senior Biostatistician](https://feeny.ai/job/senior-biostatistician-freenome-remote-dah4h40pkygs)