--- title: 'Staff Technical Operations Scientist at Freenome' canonical: 'https://feeny.ai/job/staff-technical-operations-scientist-freenome-brisbane-5xdj1a8tctn9' type: 'job' last_seen: '2026-10-19' --- # Staff Technical Operations Scientist at Freenome - **Company:** Freenome - **Location:** Brisbane, CA - **Work type:** hybrid - **Posted:** 2026-10-06 - **Last confirmed live:** 2026-10-19 - **Apply:** https://job-boards.greenhouse.io/freenome/jobs/8864622002 ## Job description About this opportunity: At Freenome, we are seeking a Staff Technical Operations Scientist to help grow the Freenome Manufacturing Science and Technology (MSAT) team. The ideal candidate is in Next-Generation Sequencing (NGS) workflows, detail-orientated, and familiar working within a CLIA laboratory setting. This person is responsible for all things related to Technology transfer and supporting root cause analysis of commercial issues. You are passionate about contributing to developing life-saving diagnostics through early cancer detection, and you will have a significant impact on the continued growth of an organization dedicated to changing the entire landscape of cancer. The role reports to the Senior Manager of Technical Operations. This role will be a Hybrid role based in our Brisbane, California headquarters. What you’ll do: - Support day-to-day Manufacturing/QC and Clinical Lab operations by providing scientific and technical guidance. - Monitor process performance and analyze manufacturing/QC data to identify trends, variability, and opportunities for improvement. - Lead investigations related to Manufacturing/QC nonconformances, out-of-specification (OOS) results, and process excursions using root cause analysis tools. - Author Nonconformances reports, CAPAs, change controls, risk assessments, and technical documentation. - Collaborate with cross-functional teams to implement corrective and preventive actions that improve process reliability and product quality. - Lead process validation, equipment qualification, and technology transfer activities. - Participate in Manufacturing/QC readiness activities for new products or process changes. - Create validation documentation for Manufacturing/QC and ensure accuracy and compliance with GMP requirements. - Create statistical analyses and preparation of technical reports to support process monitoring and decision-making. - Lead continuous improvement initiatives focused on process chemistry efficiency. - Maintain knowledge of applicable regulatory requirements, GMP guidelines, and company procedures. - Present technical findings and project updates to internal stakeholders. Must haves: - Bachelor's degree in Chemistry, Biology, Biochemistry, Biomedical Engineering, Chemical Engineering, Pharmaceutical Sciences, or a related scientific discipline. - 12 years of experience in pharmaceutical, biotechnology, medical device, or related regulated manufacturing environments (internships and co-op experience may be considered). - Strong analytical and problem-solving skills. - Excellent written and verbal communication skills. - Ability to work effectively in a cross-functional, team-oriented environment. - Proficiency with Microsoft Office applications, particularly Excel and PowerPoint. - Experience with NGS workflows and chemistry. - Experience working in a GMP-regulated environment, CAP/CLIA, ISO13485 or IVD environment. - Knowledge of process validation principles and test method validation. - Experience with manufacturing investigations, CAPA, change control, or quality systems. - Experience with automated Liquid handling such as Hamilton/Tecan. - Experience with statistical software such as JMP or Minitab/Python/R. Nice to haves: - Exposure to Lean, Six Sigma, or continuous improvement methodologies. - Experience using systems such as Netsuite, LIMS, or electronic batch records. Benefits and additional information: The US target range of our base salary rate for new hires is $157,675.00 - $221,550.00. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.  Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ [freenome.com/job-openings/](http://freenome.com/job-openings/) for additional company information. Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Applicants have rights under Federal Employment Laws. - https://www.dol.gov/agencies/whd/posters/fmla - https://www.dol.gov/agencies/ofccp/posters - https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act California applicants please review the CCPA Notice at Collection here: - https://www.freenome.com/ccpa-privacy-notice-for-freenome-california-job-applicants/ ## #LI-HYBRID ## About Freenome ## Company Overview - **One-liner**: Freenome is a biotechnology company developing blood-based multi-omics tests powered by machine learning to detect cancer in its earliest, most treatable stages. - **Entity Type**: Private (Late Stage) – raised over $2B in total funding; stock symbol FRNM (NASDAQ) is associated with a related SPAC entity but the operating company remains privately held [linkedin.com] - **Headquarters**: Brisbane, California, United States - **Founded**: 2014 - **Founders**: Riley Ennis (Co-Founder and Chief Product Officer) and others [freenome.com] ## Core Business - **Primary industry**: Biotechnology / Early Cancer Detection - **Target customers**: B2B (health systems, insurers, employers) and B2C (patients via healthcare providers) - **Mission**: To create tools that empower everyone to prevent, detect, and treat their disease, starting with early cancer detection. ## Products & Services - **Freenome Multi-Omics Blood Test (Colorectal Cancer)**: A next-generation blood test that uses a multi-omics platform (cell-free DNA, methylation, proteins, etc.) combined with machine learning to detect early-stage colorectal cancer and advanced adenomas. Type: Diagnostic test (IVD) – currently under clinical validation and regulatory review [freenome.com]. ## Market Standing - **Valuation / Market Cap**: Not publicly disclosed (private). Total funding of $2.07B (LinkedIn estimate) or $1.428B (CB Insights); conflicting reports reflect different counting methods [linkedin.com], [cbinsights.com] - **Key Metric (Funding)**: Most recent round – $75M corporate round (Nov 2025) led by Roche, plus $254M venture round (Feb 2024) also led by Roche [linkedin.com] - **Notable Investors**: Perceptive Advisors, RA Capital Management, Roche Venture Fund, Kaiser Permanente, Novartis, American Cancer Society’s BrightEdge Ventures, Exact Sciences [linkedin.com], [freenome.com] - **Growth Signals**: - Blood-based test included in updated American Cancer Society colorectal cancer screening guideline - Appointed industry veteran Rob Guigley as Chief Commercial Officer (2025) - Ongoing clinical programs for multiple cancer types - Employee headcount of 304 with 22 active job postings (as of mid-2025) [linkedin.com] ## Competitive Advantages - **Multi-omics + AI platform**: Combines multiple biological signals (DNA methylation, fragmentomics, proteins) with proprietary machine learning algorithms to achieve high sensitivity and specificity for early-stage cancer. - **Strong clinical program**: Rigorous multi-site studies and partnerships with leading health systems (e.g., Kaiser Permanente). - **Deep investor backing**: Long-term support from top healthcare investors and strategic partners (Roche, Exact Sciences) provides capital and commercial pathways. - **First-mover in multi-cancer blood screening**: Focus on colorectal cancer as first indication, with potential to expand to other cancers. ## Strategic Focus - **Clinical validation & regulatory approval**: Completing pivotal studies and preparing FDA submission for colorectal cancer test. - **Commercial launch preparation**: Building commercial team (hiring Strategic Account Executives, VP Revenue Cycle Management) and establishing relationships with payers and health systems. - **Platform expansion**: Extending multi-omics technology to additional cancer types (lung, pancreatic, etc.) through research programs. ## Why Work Here - **Mission-driven culture**: Employees are motivated by the opportunity to “outpace cancer” and make a tangible impact on patient lives. Values include integrity, empathy, trust, servant leadership, and striving for greatness [freenome.com]. - **Equity ownership**: Every U.S. full-time employee receives equity packages, aligning personal success with company milestones [freenome.com/careers]. - **Competitive benefits**: Comprehensive medical plans, wellness programs, generous PTO, 12 paid holidays, annual bonus opportunities, and market-based salaries [freenome.com/careers]. - **Collaborative environment**: Cross-functional teams across clinical, scientific, and business domains; emphasis on respect and inclusion [freenome.com/careers]. - **Work model**: Likely office-based in Brisbane, CA (hybrid flexibility not explicitly stated). The company has a physical lab and office presence. - **Engineering & science culture**: Opportunity to work with state-of-the-art multi-omics data, machine learning, and clinical trial design. The team includes senior ML scientists, computational biologists, and software engineers. ## Sources 1. [freenome.com](https://www.freenome.com/) – Company overview, leadership, values, products 2. [freenome.com/careers](https://www.freenome.com/careers/) – Benefits, culture, job openings 3. [linkedin.com/company/freenome](https://www.linkedin.com/company/freenome) – Employee count, revenue estimate, funding rounds, investor list, recent hires and departures 4. [cbinsights.com/company/freenome](https://www.cbinsights.com/company/freenome) – Funding total, company description, patent activity ## Other roles at Freenome - [Clinical Laboratory Associate I (Contractor)](https://feeny.ai/job/clinical-laboratory-associate-i-contractor-freenome-brisbane-1b34jywjwynk) — Brisbane, CA - [Clinical Laboratory Scientist I](https://feeny.ai/job/clinical-laboratory-scientist-i-freenome-brisbane-32abdtdbq9nf) — Brisbane, CA - [Clinical Laboratory Scientist II](https://feeny.ai/job/clinical-laboratory-scientist-ii-freenome-brisbane-4h6ask34v1k9) — Brisbane, CA - [Senior Clinical Laboratory Scientist](https://feeny.ai/job/senior-clinical-laboratory-scientist-freenome-brisbane-rpddjs1faw0k) — Brisbane, CA - [Supervisor, Analytical Laboratory](https://feeny.ai/job/supervisor-analytical-laboratory-freenome-brisbane-89j954tn8spd) — Brisbane, CA - [Automation Service Engineer II](https://feeny.ai/job/automation-service-engineer-ii-freenome-brisbane-gsqf06gpzyk0) — Brisbane, CA - [Automation Service Engineer I](https://feeny.ai/job/automation-service-engineer-i-freenome-brisbane-sh4fttty91y6) — Brisbane, CA - [Inventory Specialist I (Contractor)](https://feeny.ai/job/inventory-specialist-i-contractor-freenome-brisbane-8v9zfjv84m70) — Brisbane, CA - [Quality Control Specialist I (Contractor)](https://feeny.ai/job/quality-control-specialist-i-contractor-freenome-brisbane-mc4bcf1nyhjs) — Brisbane, CA - [Quality Control Specialist II (Contractor)](https://feeny.ai/job/quality-control-specialist-ii-contractor-freenome-brisbane-94f4tb6dq8g8) — Brisbane, CA