---
title: 'Vice President, Commercial Operations (Tumor HI Program) at Rezolute'
canonical: 'https://feeny.ai/job/vice-president-commercial-operations-tumor-hi-program-rezolute-redwood-city-mpefsk25mt6n'
type: 'job'
last_seen: '2026-11-06'
---

# Vice President, Commercial Operations (Tumor HI Program) at Rezolute

- **Company:** Rezolute
- **Location:** Redwood City, CA
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-06-02
- **Last confirmed live:** 2026-11-06
- **Apply:** https://jobs.lever.co/rezolutebio/aeb3cc75-59c8-4fd2-a673-2973844cb3ea

## Job description

Rezolute is a late-stage rare disease biopharmaceutical company focused on developing transformative therapies for patients living with severe metabolic and endocrine disorders. Our mission is to bring hope and meaningful solutions to patients and families affected by rare and difficult-to-treat diseases through scientific innovation, collaboration, and integrity. Rezolute’s lead investigational therapy, RZ358 (ersodetug), is a fully human monoclonal antibody in late-stage clinical development for the treatment of hypoglycemia due to congenital and acquired forms of hyperinsulinism (HI). As Rezolute expands its medical and scientific focus into tumor-related hyperinsulinism (tumor HI), most commonly related to pancreatic neuroendocrine tumors (insulinomas) or paraneoplastic hypoglycemia (NICTH), the company is committed to advancing novel therapeutic strategies that address this rare and complex form of hypoglycemia associated with insulin-secreting tumors and related neuro-oncology disorders. Position Summary We are seeking a dynamic and experienced Vice President of Commercial Operations to establish and lead all operational aspects of our commercial strategy in support of the launch of our first rare disease therapy. This includes managing commercial operations functions ensuring the infrastructure, processes, and strategies necessary for successful product launch. This individual will be a strategic and hands-on leader responsible for building and managing critical commercial infrastructure, including sales operations, analytics, forecasting, market access operations, and commercial systems. This role oversees sales operations, forecasting and analytics, incentive compensation, market research, data management, CRM systems, field effectiveness, and commercial training. The ideal candidate has experience in rare disease or specialty pharmaceutical markets and thrives in an entrepreneurial, fast-paced environment. The ideal candidate has experience in rare disease or specialty pharmaceutical markets and thrives in an entrepreneurial, fast-paced environment. This role is based in the home office and requires minimum of 3 days per week in the office.

## Key Responsibilities

- Serve as a key member of the Commercial Leadership Team, developing and executing commercial strategy and operations plans.
- Develop and execute the commercial operations infrastructure to support a successful rare disease product launch.
- Lead commercial planning processes, including sales forecasting, demand planning, incentive compensation design, and territory alignment.
- Build and oversee a high-functioning sales operations team and associated systems (CRM, data warehousing, reporting dashboards).
- Establish data governance processes and manage third-party vendors providing data (claims, specialty pharmacy, distribution).
- Partner cross-functionally with Market Access, Marketing, Medical Affairs, Finance, and IT to ensure alignment of commercial operations with overall corporate goals.
- Design and manage KPIs and reporting frameworks to track performance and inform commercial decision-making.
- Lead field force enablement efforts, including CRM configuration, targeting, call planning, and field reporting.
- Support the development of compliant policies and processes for commercial activities in collaboration with Legal and Compliance teams.
- Manage operational budgets, contracts, and vendor relationships for commercial functions.

Qualifications:

- Bachelor’s degree required; MBA or advanced degree preferred.
- 12+ years of progressive experience in commercial operations within the biopharmaceutical industry, including at least 5 years in a leadership role.
- Direct experience supporting launch planning and execution for rare disease or specialty products.
- Deep understanding of commercial data sources (e.g., specialty pharmacy, HUB services, patient services, claims data).
- Demonstrated success in building commercial infrastructure in a high-growth or startup environment.
- Strong project management skills, attention to detail, and ability to lead cross-functional initiatives.
- Excellent communication and leadership skills with a collaborative approach.
- Familiarity with compliance regulations in the rare disease space.

## Preferred Attributes

- Experience in both pre-commercial and commercial-stage biotech organizations.
- Entrepreneurial mindset and comfort operating in a fast-paced, evolving environment.
- Ability to work in a lean organization with a hands-on, roll-up-your-sleeves style.
- Passion for serving patients with serious or underserved diseases.

Rezolute (RZLT) currently anticipates the base salary for the Vice President of Commercial Operations role could range from $300,000 to $360,000 and will depend, in part, on the successful candidate’s geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company’s discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience and geographical location of the selected candidate. Qualifying employees are eligible to participate in benefit programs such as: Health Insurance (Medical / Dental / Vision) Disability, Life & Long-Term Care Insurance Holiday Pay Tracking Free Vacation Program 401(k) Plan Match Educational Assistance Benefit Fitness Center Reimbursement

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.

## About Rezolute

## Company Overview
- **One-liner**: Rezolute is a late-stage rare disease biotechnology company developing ersodetug, a monoclonal antibody therapy for hypoglycemia caused by congenital and tumor hyperinsulinism.
- **Entity Type**: Public (Nasdaq: RZLT)
- **Headquarters**: Redwood City, California, United States (with an additional office in Louisville)
- **Founded**: Not publicly available (IPO 2012)
- **Founders**: Not publicly available

## Core Business
- **Primary industry**: Biotechnology – rare disease therapeutics
- **Target customers**: B2B – healthcare providers, patients, and payers; focuses on addressing severe unmet medical needs in hyperinsulinism
- **Mission/purpose**: Significantly improve outcomes for individuals with hypoglycemia caused by hyperinsulinism ([rezolutebio.com – About](https://rezolutebio.com/job-openings/))

## Products & Services
- **Ersodetug (lead candidate)**: An intravenously administered human monoclonal antibody that allosterically binds to the insulin receptor, down‑modulating insulin action to restore normal glucose levels. Being developed for two indications:
  - **Congenital Hyperinsulinism (sunRIZE Phase 3 study)** – completed enrollment (May 2025) with 62 participants; topline results expected December 2025.
  - **Tumor Hyperinsulinism (upLIFT Phase 3 study)** – initiated mid‑2025; FDA agreed to a single‑arm open‑label design; topline results expected second half 2026.
  - Designations: Orphan Drug (US/EU), Rare Pediatric Disease, Breakthrough Therapy (US), PRIME (EU), ILAP (UK) ([ir.rezolutebio.com – 10-K](https://ir.rezolutebio.com/sec-filings/content/0001104659-25-090848/0001104659-25-090848.pdf))

## Market Standing
- **Valuation/Market Cap**: $317.7 million (as of recent data, per LinkedIn) ([linkedin.com](https://linkedin.com/company/rezolute))
- **Key Metric (Public)**: Annual revenue of $14.1 million (likely from grants or collaboration revenue; no product revenue yet) ([linkedin.com](https://linkedin.com/company/rezolute))
- **Notable Investors/Partners**: Not publicly available – company is publicly traded and does not disclose a lead investor list. Key partners include clinical trial sites and regulatory agencies (FDA, EMA).
- **Growth Signals**:
  - Headcount: 50 employees (+2.9% YoY) ([linkedin.com](https://linkedin.com/company/rezolute))
  - Phase 3 sunRIZE study fully enrolled; topline data pending December 2025.
  - Phase 3 upLIFT study enrolling with streamlined design; data expected second half 2026.
  - FDA granted Breakthrough Therapy Designation for tumor HI in May 2025.
  - Multiple regulatory designations accelerating development pathway.

## Competitive Advantages
- **Unique mechanism**: Ersodetug acts downstream from beta cells at the insulin receptor, allowing it to potentially treat all forms of hyperinsulinism (genetic or acquired) regardless of underlying cause.
- **Dosing convenience**: Half‑life >2 weeks enables monthly intravenous administration.
- **Regulatory momentum**: Orphan Drug, Rare Pediatric Disease, Breakthrough Therapy, PRIME, and ILAP designations provide expedited review, potential priority review voucher, and closer FDA/EMA collaboration.
- **Pivotal data catalysts**: Two Phase 3 studies read out within ~12‑18 months, creating clear value inflection points.

## Strategic Focus
- Execute the two ongoing Phase 3 trials (sunRIZE in congenital HI, upLIFT in tumor HI).
- Assuming positive topline data from sunRIZE, submit a Biologics License Application (BLA) to the FDA for ersodetug in mid‑2026.
- Continue to build commercial and medical affairs infrastructure (recent job postings indicate hires in Commercial Operations, Marketing, Payer Strategy, and Supply Chain) ([rezolutebio.com – Job Openings](https://rezolutebio.com/job-openings/)).

## Why Work Here
- **Mission‑driven**: Employees work on therapies for ultra‑rare, life‑threatening conditions with high unmet medical need.
- **Benefits**: Comprehensive health/dental/vision insurance, competitive salaries, annual bonus, 401(k) with company match, tuition assistance, on‑site meals, flexible spending accounts ([rezolutebio.com – Benefits](https://rezolutebio.com/job-openings/)).
- **Work environment**: Hybrid/office policy not explicitly stated; roles are based in Redwood City (HQ) and Louisville. Recent openings include remote-friendly functions? Not confirmed.
- **Growth opportunity**: Small company (~50 people) entering late‑stage development and pre‑commercial build‑out – employees can have broad impact and career advancement.
- **Engineering culture**: For biotech, the focus is on clinical operations, regulatory, and commercial roles rather than traditional engineering. IT positions (Business System Engineer) exist.

## Sources
1. [linkedin.com – Rezolute company page](https://linkedin.com/company/rezolute)
2. [rezolutebio.com – Job Openings & Benefits](https://rezolutebio.com/job-openings/)
3. [ir.rezolutebio.com – SEC 10-K Filing (September 2025)](https://ir.rezolutebio.com/sec-filings/content/0001104659-25-090848/0001104659-25-090848.pdf)
4. [rezolutebio.com – Leadership page](https://rezolutebio.com/leadership/)

## Other roles at Rezolute

- [Director – Biostatistics](https://feeny.ai/job/director-biostatistics-rezolute-redwood-city-rsdg74z82vkk) — Redwood City, CA
- [Medical Science Liaison / Senior Medical Science Liaison - Oncology / Rare Endocrine Disorders](https://feeny.ai/job/medical-science-liaison-senior-medical-science-liaison-oncology-rare-endocrine-bhs2782j7gtm)
- [Medical Science Liaison / Senior Medical Science Liaison - Pediatric Endocrinology / Rare Metabolic Disorders](https://feeny.ai/job/medical-science-liaison-senior-medical-science-liaison-pediatric-endocrinology-pvkvqb4szfae)
- [Recruiting Coordinator & Scheduler – 6 month contract](https://feeny.ai/job/recruiting-coordinator-scheduler-6-month-contract-rezolute-redwood-city-x0gcanx9q7vf) — Redwood City, CA
- [Contract Recruiter (Biopharmaceutical Industry) 6 month contract](https://feeny.ai/job/contract-recruiter-biopharmaceutical-industry-6-month-contract-rezolute-redwood-jvpc3bn5g8t2) — Redwood City, CA
- [Senior Manager, Scientific Communications & Medical Education](https://feeny.ai/job/senior-manager-scientific-communications-medical-education-rezolute-redwood-city-363wemxkxap1) — Redwood City, CA
- [Head of Product Launch Program Management (Rare Disease)](https://feeny.ai/job/head-of-product-launch-program-management-rare-disease-rezolute-redwood-city-7qka6sahvk1h) — Redwood City, CA
- [Associate Director, Medical Affairs Operations](https://feeny.ai/job/associate-director-medical-affairs-operations-rezolute-redwood-city-gg2p7j75sszn) — Redwood City, CA
- [Vice President, Global Manufacturing](https://feeny.ai/job/vice-president-global-manufacturing-rezolute-redwood-city-wcyqhfyet1yw) — Redwood City, CA
- [Vice President, Global Supply Chain](https://feeny.ai/job/vice-president-global-supply-chain-rezolute-redwood-city-q0dngx787mdk) — Redwood City, CA