---
title: 'Vice President, Marketing & Sales at Tango Therapeutics'
canonical: 'https://feeny.ai/job/vice-president-marketing-sales-tango-therapeutics-boston-ex81335qs4hc'
type: 'job'
last_seen: '2026-09-08'
---

# Vice President, Marketing & Sales at Tango Therapeutics

- **Company:** Tango Therapeutics
- **Location:** Boston, MA
- **Compensation:** $302k–$452k
- **Posted:** 2026-09-06
- **Last confirmed live:** 2026-09-08
- **Apply:** https://job-boards.greenhouse.io/tangotherapeutics/jobs/7986730003

## Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

As Tango transitions into a fully integrated, commercial-stage biopharmaceutical organization, the Vice President of Marketing and Sales will serve as a core pillar of the Commercial Leadership Team. Reporting to the Chief Commercialization Officer, this executive will be responsible for architecting the overarching commercial strategy, establishing our market presence, and driving the successful launch of our precision oncology assets, starting with our oral PRMT5 inhibitors.

The ideal candidate brings an enterprise mindset and a proven track record of successfully launching oral oncology therapies. By combining the rigorous, scaled commercial discipline of large, established pharmaceutical organizations with the agility and entrepreneurial spirit of a fast-paced biotech, this leader will build a high-impact, scientifically driven commercial organization. Success in this role requires exceptional cross-functional leadership, guiding overarching corporate strategy, and ensuring seamless integration across commercial, scientific, and operational domains.

Your Role:

Enterprise Leadership & Cross-Functional Strategy

- Corporate Strategy Alignment: Act as a critical voice on the leadership team, ensuring that commercial strategies are deeply integrated with the company’s broader corporate goals, financial planning, and long-term vision
- Regulatory & Development Partnership: Collaborate closely with Clinical Development and Regulatory Affairs to inform clinical trial designs, shape Target Product Profiles (TPPs), and align on label negotiation strategies and post-approval lifecycle management
- Cross-Functional Synergy: Build seamless, highly collaborative partnerships across Medical Affairs, Market Access, Finance, and Corporate Communications to ensure unified product positioning and a cohesive narrative across all stakeholder touchpoints
- Commercial Architecture: Design and scale the foundational marketing and sales infrastructure from the ground up, transitioning the organization from clinical-stage to commercial readiness while maintaining a lean, high-performing culture

Marketing Strategy & Brand Leadership

- Brand & Disease State Positioning: Lead the development of compelling disease awareness campaigns, scientific narratives, and pre-launch brand positioning that clearly communicate the value of our precision oncology assets
- Omnichannel Strategy: Direct the creation of a robust, data-driven digital and non-personal engagement model tailored to the specific behaviors and preferences of medical oncologists and academic centers
- Market Insight & Competitive Intelligence: Drive comprehensive market research initiatives to anticipate shifts in the oral oncology landscape, deeply understand patient journeys, and continuously refine commercial strategy based on real-time data

Sales Strategy & Execution

- Field Force Architecture: Define the optimal field force sizing, territory alignment, and deployment strategy for a highly specialized oncology sales team
- Launch Readiness: Drive the operational and strategic readiness of the sales organization, ensuring rigorous training and certification of the field team on the complex science behind biomarker-driven treatments
- Customer Engagement: Cultivate and maintain executive-level relationships with Key Opinion Leaders (KOLs), academic oncology networks, and major community oncology practices to drive scientific share of voice

What you bring:

- Bachelor’s degree in a scientific or business discipline required; MBA or advanced scientific degree (PharmD, PhD) strongly preferred
- 20+ years of progressive commercial leadership experience in the biopharmaceutical industry, with a mandatory blend of experience in large, established pharmaceutical organizations (best practices, scale, strategic rigor) and biotech environments (agility, foundational buildout, resource optimization)

Core Competencies

- Oncology Expertise: Deep expertise in the oncology market is required, with a strong track record of launching and commercializing oral oncology and precision/biomarker-driven therapies
- Enterprise Mindset: Demonstrated ability to think beyond the commercial function, understanding the complexities of drug development, regulatory pathways, and corporate finance to drive holistic company success
- Cross-Functional Leadership: Proven experience successfully partnering with R&D, Regulatory, and Medical Affairs in a highly matrixed, science-first environment
- Culture & Team Building: Exceptional track record of attracting, developing, and retaining top-tier commercial talent while fostering a collaborative, patient-centric, and performance-driven culture

#LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range $301,600—$452,400 USD

## About Tango Therapeutics

## Company Overview
- **One-liner**: Tango Therapeutics is a clinical-stage biotechnology company leveraging the principle of synthetic lethality to discover and develop next-generation precision cancer medicines for genetically defined patient populations.
- **Entity Type**: Public (NASDAQ: TNGX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2017
- **Founders**: Not publicly disclosed (launched by Third Rock Ventures)

## Core Business
- **Primary industry/industries**: Biotechnology, Precision Oncology, Drug Discovery & Development
- **Target customers**: B2B (pharma partnerships, clinical trial sites); ultimate customers are cancer patients with specific genetic tumor profiles
- **Mission or purpose statement**: "Discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways… building a road map to cures that will transform the lives of patients and their families." [tangotx.com](https://www.tangotx.com/join-us/)

## Products & Services
- **Vopimetostat (PRMT5 inhibitor)**: A clinical-stage, wholly-owned program targeting MTAP-deleted cancers, including pancreatic, lung, and glioblastoma. Currently in Phase 1/2 trials. [tangotx.com](https://www.tangotx.com/pipeline/)
- **TNG456 (PRMT5 inhibitor)**: A next-generation PRMT5 inhibitor for MTAP-deleted cancers, currently in pre-clinical development.
- **Daraxonrasib (RAS inhibitor)**: A combination therapy (with vopimetostat) for MTAPdel/RASmut pancreatic and lung cancers. Recently reported a 92% objective response rate in pancreatic cancer in a Phase 1/2 trial. [tangotx.com](https://www.tangotx.com/)
- **CRISPR-based Target Discovery Engine**: A proprietary platform for identifying novel synthetic lethal targets, enabling a robust pipeline of wholly-owned programs.

## Market Standing
- **Valuation/Market Cap**: ~$1.05 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Key Metric**: Annual Revenue of ~$62.4 million; Total Funding raised ~$901 million (including post-IPO). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Notable Investors/Partners**: Third Rock Ventures (lead Series A), Boxer Capital (lead Series B), BCTG Acquisition Corp (parent). Strategic partners include pharma and biotech companies (collaborations under active exploration). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Growth Signals**: Completed a $600 million upsized public offering in June 2026; strong clinical data (92% ORR in pancreatic cancer); pipeline expanding into glioblastoma; headcount growth in job postings (+400% YoY in active roles). [tangotx.com](https://www.tangotx.com/)

## Competitive Advantages
- **Synthetic Lethality Expertise**: A deep, proprietary understanding of CRISPR-based target discovery to identify novel vulnerabilities in cancers with tumor suppressor gene loss, undruggable oncogenes, and immune evasion mechanisms.
- **Genetically Defined Patient Selection**: All programs are designed for well-defined patient populations with clear biomarkers, increasing the probability of clinical success and reducing trial risk.
- **Wholly-Owned Pipeline**: Unlike many biotechs that license out rights, Tango retains full ownership of its lead programs, capturing maximum value.
- **Strong Financial Position**: With over $1B in market cap and a recent $600M offering, the company is well-capitalized to advance its pipeline through pivotal trials.

## Strategic Focus
- **Current priorities**: Advancing vopimetostat and daraxonrasib into Phase 3 trials for pancreatic and lung cancers; expanding the pipeline into glioblastoma; continuing to discover and validate new synthetic lethal targets; building out commercial manufacturing and clinical operations infrastructure.
- **Direction for growth**: Becoming a fully-integrated biotechnology company capable of bringing its own medicines to market, while selectively pursuing strategic collaborations to expand reach.

## Why Work Here
- **Culture highlights**: Emphasizes "urgency + compassion," "courage + leadership," "spirit + resilience," and "embrace individuality and face challenges together." Described as a team of "passionate problem solvers" who are "all in for exciting science and changing lives." [tangotx.com](https://www.tangotx.com/join-us/)
- **Remote/hybrid/office policy**: Primarily on-site at Boston HQ (201 Brookline Ave, Suite 901, Boston, MA). Roles appear to be Boston-based, though some field-based positions (e.g., Medical Science Liaisons) are remote.
- **Notable perks or engineering culture**: High scientific ambition with a clear patient-first mission; strong leadership team with deep oncology experience; active hiring across clinical operations, biostatistics, medical affairs, and legal/compliance; 15+ active job postings with significant YoY growth in roles. [greenhouse.io](http://job-boards.greenhouse.io/tangotherapeutics)
- **Workforce**: ~129 employees, with a mix of research (26%), medical (12%), and operations roles. Notable alumni from Novartis, Vertex, Takeda, and Broad Institute. [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)

## Sources
1. [Tango Therapeutics Official Website](https://www.tangotx.com/)
2. [Tango Therapeutics Careers Page (Greenhouse)](http://job-boards.greenhouse.io/tangotherapeutics)
3. [Tango Therapeutics LinkedIn Profile](https://www.linkedin.com/company/tango-therapeutics)
4. [Tango Therapeutics Pipeline Page](https://www.tangotx.com/pipeline/)
5. [Tango Therapeutics Join Us Page](https://www.tangotx.com/join-us/)

## Other roles at Tango Therapeutics

- [Executive Director, Insights & Analytics](https://feeny.ai/job/executive-director-insights-analytics-tango-therapeutics-boston-4f5kkx80kztw) — Boston, MA
- [Senior Vice President, Market Access](https://feeny.ai/job/senior-vice-president-market-access-tango-therapeutics-boston-47tt1fw4qxxq) — Boston, MA
- [Senior Manager, Clinical Informatics](https://feeny.ai/job/senior-manager-clinical-informatics-tango-therapeutics-boston-g3pk44zmymam) — Boston, MA
- [Executive Director, FP&A](https://feeny.ai/job/executive-director-fp-a-tango-therapeutics-boston-kph81hnp4jvk) — Boston, MA
- [Manager, Total Rewards](https://feeny.ai/job/manager-total-rewards-tango-therapeutics-boston-fywb3xy2sabn) — Boston, MA
- [Associate Director, Pharmacovigilance Scientist](https://feeny.ai/job/associate-director-pharmacovigilance-scientist-tango-therapeutics-boston-5cgk3mmdsprr) — Boston, MA
- [Associate Medical Director, Pharmacovigilance](https://feeny.ai/job/associate-medical-director-pharmacovigilance-tango-therapeutics-boston-4kcjnjy0vpys) — Boston, MA
- [Executive Director, Clinical Development](https://feeny.ai/job/executive-director-clinical-development-tango-therapeutics-boston-xhzk5j65r72k) — Boston, MA
- [Clinical Trials Manager](https://feeny.ai/job/clinical-trials-manager-tango-therapeutics-boston-7yaaz94j244a) — Boston, MA
- [Senior Director, Clinical Sciences](https://feeny.ai/job/senior-director-clinical-sciences-tango-therapeutics-boston-j8hypf1vqq14) — Boston, MA