Cellular Biologist at Topos Bio (South San Francisco, CA)
Topos Bio· South San Francisco, CA·
Role details
Work type
Onsite
Employment
Full-Time
Job description
Topos Bio At Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease. We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.
What you will do
- Develop and optimize mammalian cell-based assays for disordered protein targets
- Execute phenotypic and reporter-based screening campaigns to validate computational hits
- Characterize compound activity and support structure-activity relationship studies
- Collaborate with computational scientists to integrate experimental data with modeling workflows
- Establish robust assay protocols and quality control metrics
What we are looking for
- Strong foundation in mammalian cell culture and cellular assay development
- Experience with disease-relevant cellular models
- Ability to troubleshoot complex biological systems and optimize experimental protocols
- Track record of productivity and effective collaboration
Preferred
- PhD in cell and molecular biology with focus on disease models
- Industry experience in drug discovery or biotech
- Experience with reporter assays and high-throughput screening platforms
- Familiarity with oncology, neurodegeneration, or metabolic disease models
- Track record of developing novel cellular assays or screening approaches
Why work at Topos Bio
- Mission-Driven: The opportunity to work on a fundamental problem in biology—modeling protein dynamics—with the potential to cure some of the most devastating human diseases.
- Cutting-Edge Science: Work at the intersection of AI (generative models, foundation models) and biophysics (molecular dynamics, structural biology) on a novel approach that challenges the status quo.
- Hybrid Workspace: The company operates with a hybrid model, allowing for a combination of remote and on-site work in San Francisco.
- Early-Stage Impact: As a small, well-funded seed-stage company (16 employees), new hires will have significant ownership and influence over the platform and pipeline direction.
- Strong Founding Team: Led by experienced founders and scientists from top institutions (Berkeley, Stanford, Intel, Rezo Therapeutics), with a board including notable tech and biotech figures.