Senior/Research Associate, Functional Genomics at NewLimit (South San Francisco, CA)
NewLimit· South San Francisco, CA·
Job description
About NewLimit
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Position
NewLimit is seeking a Senior/Research Associate with experience in molecular biology to join our Epigenetic Editing group. Pooled screening technologies are at the heart of our discovery engine, allowing us to rapidly search for epigenetic reprogramming therapies that restore cell function and reduce the burden of disease.
As a member of our team, you will:
- Collaborate with our Single Cell Technology team to implement large-scale, single cell perturbation experiments with custom chemistries
- Build recombinant DNA vectors by synthesis and cloning to enable large-scale single cell perturbation experiments
- Prepare, titer, and apply viral vectors (lentiviral, AAV) to transduce mammalian cell lines and primary cells
- Contribute to scaling and improving pooled single cell perturbation screens
Requirements
- Bachelor’s degree in cell biology, molecular biology, or a related natural science or industry experience
- 2+ years of work experience in a cell or molecular biology laboratory (academic or industry)
- Experience with molecular cloning, nucleic acid analysis (RT-qPCR, gel electrophoresis), and related molecular biology methods
- Experience with mammalian cell culture
Nice to have
- Experience with next-generation sequencing assays and functional genomics
- Experience with FACS or flow cytometry
- Computational skills for next-generation sequencing analysis (Python programming, Unix)
- Experience with single cell genomics methods
- Experience with epigenetic reprogramming methods for cell fate engineering or targeted epigenetic editing
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
- Meals and snacks on-site
Salary Range: $75,000 to $100,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.
Why work at NewLimit
- Culture: "Not for the faint of heart" — a high-performance, mission-focused team. No pure management roles; everyone executes. Values include safety then speed, clear communication, inherent optimism, independent thinking, and top talent in every seat newlimit.com.
- Remote/Hybrid/Office: Likely on-site/hybrid given the lab-based nature of the work (headquarters in South San Francisco).
- Notable Perks: Competitive salaries, comprehensive health benefits (medical, dental, vision), equity packages, 401(k) with up to 4% match, generous parental leave, 20 days PTO + 15 holidays, free EV charging newlimit.com.
- Engineering Culture: Strong emphasis on computational biology, machine learning, and functional genomics. The team spans both wet-lab and dry-lab disciplines, with a focus on building scalable methods and iterative data-driven discovery.