Senior Software Engineer Full-stack at InsightRX (Remote)

InsightRX·5d ago

Role details

Work type

Remote

Job description

InsightRX | Engineering

About the Role

InsightRX is looking for a Full Stack Engineer to help build our Astra AI platform — a system that combines a modern web application with conversational AI agents to support pharmacokinetic/pharmacodynamic (PK/PD) analysis and clinical trial data workflows. You'll work across the client, server, and agent layers, understanding how they fit together end to end: how the frontend talks to the API, how the API queues and tracks work, and how LLM-powered agents process data and return results.

This is a strong fit for someone who enjoys working across the stack, is comfortable navigating both traditional web application architecture and newer LLM-agent design patterns, and wants to build tools used directly in pharmaceutical R&D decision-making.

What You'll Work On

Build and maintain features across our React/TypeScript client and NestJS/TypeScript backend, including UI components, REST APIs, and the data layer connecting them.
Design and extend the client-server architecture: state management, routing, authentication (including SSO/SAML), real-time updates via WebSockets, and background job processing via AWS SQS.
Collaborate on the integration layer between the web app and our LLM-based agents — message schemas, queue-based communication, and file/data handoff.
Work with our conversational AI agent system, which orchestrates multiple specialized agents for statistical modeling, data quality checks, and PK/PD analysis workflows.
Contribute to database schema design and migrations (PostgreSQL/Sequelize), API documentation (Swagger), and test coverage (Jest, pytest).
Participate in code review, architecture discussions, and production support across the stack.

What We're Looking For

Strong professional experience building production level full stack web applications, comfortable owning features from database to UI.
Strong TypeScript skills across both frontend (React) and backend (Node.js/NestJS) contexts.
Experience designing REST APIs, relational data models (PostGresSQL, MongoDB), and authentication/authorization flows.
Familiarity with message-queue or event-driven architectures (SQS, similar).
Comfort reading and reasoning about systems that integrate with LLMs — understanding agent/tool patterns, prompt-driven workflows, and the practical quirks of working with LLM output, even without deep AI/ML research background.
Strong problem-solving, ownership, and ability to debug across web applications and nondeterministic AI behavior.
Uses Claude Code, Codex, or similar AI coding tools effectively while understanding, validating, and taking responsibility for the resulting code.
Good instincts for reliability and correctness in domains where data quality matters — you ask "what happens when this fails or the data is malformed."
Clear communicator, comfortable working across an evolving codebase with detailed technical documentation.
Operate with a high level of independence and cope with ambiguity

Nice to Have

Experience with LLM agent architecture a plus
Experience with SAML SSO, multi-tenant systems, or healthcare/life-sciences software.

Why work at InsightRX

Mission-driven work: The company is tackling one of medicine's hardest problems — getting the right dose to the right patient — with a clear mission to maximize therapeutic success and reduce adverse drug events.
Cross-disciplinary team: Clinicians, data scientists, pharmacometricians, and engineers collaborate closely, offering a unique environment for those interested in the intersection of software and clinical science.
Intellectual rigor: The company values "intellectually rigorous" work and "forward-looking" thinking, as stated in their core values. This is not a typical SaaS company — the science is central to everything.
Culture values: Self-directed accountability, elevating those around you, engaged and optimistic attitude, and intellectual rigor are their stated principles.
Work environment: The careers page emphasizes that "precision medicine demands precision thinking" and that the work is "as rigorous as the science demands." The team is described as diverse and mission-driven.
Remote/Hybrid/Office: Not explicitly stated in available sources, but the headquarters is in San Francisco, California.
Notable perks: The company highlights that their work is "fulfilling" and that they "collectively contribute using individual strengths." The focus is on deep domain knowledge and genuine commitment to improving patient care.

About InsightRX

Company Overview

One-liner: InsightRX develops an AI-powered precision dosing platform that helps clinicians and life science organizations individualize drug therapy to maximize safety and efficacy.
Entity Type: Private (Series A, $10M raised, plus additional debt/loan financing totaling $13.64M)
Headquarters: San Francisco, California, USA
Founded: 2015
Founders: Sirj Goswami, PhD (Co-Founder & CEO) and two other pharmacometricians

Core Business

Primary industry: Healthcare IT / Precision Medicine / Clinical Decision Support
Target customers: B2B — hospitals, health systems, academic medical centers, and life science/pharmaceutical organizations
Mission: To maximize therapeutic success through treatment individualization and population-level analysis. Their vision is a future where every approved medication works as intended, with minimal side effects.

Products & Services

InsightRX Nova: A precision dosing platform that uses Bayesian model-informed precision dosing (MIPD) to help clinicians individualize drug therapy at the point of care. It is deployed in over 1,000 hospitals and health systems.
InsightRX Apollo: A real-time analytics and population-level reporting tool for pharmacy program directors, enabling them to track dosing patterns and outcomes across their organization.
InsightRX Gemini: An automated vancomycin PK model selection tool launched in August 2024, built on an algorithm trained on more than 300,000 treatment courses.
InsightRX Astra: A conversational PK/PD analysis and end-to-end workflow automation tool for life sciences, researchers, and pharmacometricians, launched in December 2025.
InsightRX Continuous Learning: A patented process that uses real-world data to continuously improve model accuracy over time.

Market Standing

Valuation: Not publicly disclosed
Total Funding: $13.64M (including a $10M Series A in October 2019 and additional debt/loan financing)
Key Metric: Over 5.6 million patients impacted, with more than 1.9 million doses personalized using the platform. Trusted by over 1,000 hospitals and health systems.
Notable Investors/Partners: Not publicly named in available sources, but the company has raised a Series A round and additional financing.
Growth Signals: Surpassed 1,000 hospital partners; crossed 1 million patients dosed in March 2024 and 5.6 million patients impacted by May 2026; launched two major new products (Gemini in Aug 2024, Astra in Dec 2025); received CE mark certification in November 2020 for EU deployment; featured in a KLAS Emerging Company Spotlight Report with compelling customer feedback for reducing medication dosing errors.

Competitive Advantages

Science-first foundation: Founded by pharmacometricians, not generalist software engineers, giving the company deep domain expertise in quantitative pharmacology.
Patented Continuous Learning: Their platform includes a patented process that uses real-world data to continuously improve model accuracy, creating a data moat that strengthens over time.
Scale and adoption: Trusted by over 1,000 hospitals and health systems, making them the most widely adopted precision dosing vendor according to their claims.
AI grounded in science: Unlike general-purpose AI, their models are built on pharmacokinetic science, real patient data, and evidence-based protocols, making them suitable for clinical decision-making where accuracy is critical.
End-to-end solution: Covers the full spectrum from clinical development (life sciences) to point-of-care (hospitals), creating a unique value proposition.

Strategic Focus

Expanding AI capabilities: Recent launches of Gemini (automated model selection) and Astra (conversational PK/PD analysis) signal a push toward more autonomous, AI-driven workflows.
Scaling clinical adoption: With over 1,000 hospitals already using the platform, the focus is on deepening penetration within existing health systems and expanding to new ones.
Life sciences expansion: The Astra product targets pharmaceutical and research organizations, opening a new revenue stream beyond hospital clinical decision support.
Continuous model improvement: The patented Continuous Learning process is a core strategic differentiator that they are investing in to maintain their competitive edge.

Sources